Search results for "Western"
showing 10 items of 1138 documents
Western blot characterization of exosomes isolated from rat plasma and evaluation of the efficiency of a precipitation method in exosome isolation
2017
Eksosomit ovat halkaisijaltaan 40-100 nm kokoisia solunulkoisia vesikkeleitä, joita solut erittävät solunsisäisen multivesikulaarisen rakkulan yhdistyessä solukalvoon. Eksosomit ovat tärkeässä roolissa solujen välisessä viestinnässä, sillä ne kuljettavat monenlaisia biomolekyylejä, kuten useita eri RNA-tyyppejä, lipidejä ja proteiineja. Aivoissa eksosomit liittyvät neurodegeneratiivisiin sairauksiin, kuten Parkisonin tautiin, Alzheimerin tautiin ja aivovammaan. Eksosomit kykenevät läpäisemään veri-aivoesteen, ja tutkijat ovatkin esittäneet paljon kiinnostusta eksosomien mahdollisuuksiin uutena hoitokeinona. Lisäksi eksosomien kuljettamat molekyylit sisältävät tietoa eksosomit erittäneen sol…
Effects of ectopic expression of NGAL on doxorubicin sensitivity.
2012
Neutrophil gelatinase-associated lipocalin (NGAL, a.k.a Lnc2) is a member of the lipocalin family which has diverse roles including stabilizing matrix metalloproteinase-9 from auto-degradation and as siderocalins which are important in the transport of iron. NGAL also has important biological functions involved in immunity and inflammation as well as responses to kidney damage. NGAL expression has also been associated with certain neoplasia and is important in the metastasis of breast cancer. Many advanced cancer patients have elevated levels of NGAL in their urine and it has been proposed that NGAL may be a prognostic indicator for certain cancers (e.g. breast, brain, and others). NGAL exp…
Hierarchies of knowledge, incommensurabilities and silences in South African ECD policy: Whose knowledge counts?
2017
AbstractPolicy for young children in South Africa is now receiving high-level government support through the ANC’s renewed commitment to redress poverty and inequity and creating ‘a better life for all’ as promised before the 1994 election. In this article, I explore the power relations, knowledge hierarchies and discourses of childhood, family and society in National Curriculum Framework (NCF) as it relates to children’s everyday contexts. I throw light on how the curriculum’s discourses relate to the diverse South African settings, child rearing practices and world-views, and how they interact with normative discourses of South African policy and global early childhood frameworks. The NCF…
The Translation of Chinese Medical Terms into English. Linguistic Considerations on the Language of TCM
2009
The growing diffusion of TCM (Traditional Chinese Medicine) in the Western world on the one hand, and the major role of English as the language of scientific communication and international exchange on the other, have led to the need for accuracy and standardization in the English terminology of Chinese medical concepts. The complexity of Chinese medical language, not only due to the innumerable quantity of ideograms1, but above all to their correct interpretation and to the philosophical foundations which TCM is based upon, has raised several debates among linguists, translators and physicians. One of the main issues concerns the approach to be adopted in the translation of Chinese terms i…
La relació entre història de la llengua i història literària
2021
La relació entre la disciplina història de la llengua i la disciplina història de la literatura ha estat una relació de subordinació, tant des del punt vista conceptual com metodològic. La primera ha estat subordinada a la segona. En aquest article tractem en primer lloc de les circumstàncies i els esdeveniments històrics que han determinat aquesta situació de subordinació: la identificació cultural entre llengua i literatura (però amb la supeditació de la primera a la segona), el naixement de la lingüística romànica (que, paradoxalment, no va afavorir l’autonomia de la història de la llengua) i la desclosa de les cultures nacionals, que també van donar prioritat a la literatura nacional. E…
Туристические кластеры западной Украины и их научно-образовательное обеспечение
2020
The issue of forming cluster structures is very relevant for tourist destinations and certain forms of tourism in Ukraine. The scope of the study is the tourist clusters of Western Ukraine, which are characterized by high tourist attractiveness. The purpose of the study is to analyze the factors of tourist clusters formation and to develop guidelines for their scientific and educational support. Methodological and procedural framework was used to develop cluster models, as well as to typify them and assess formal and informal connections between scientific, educational institutions and cluster subjects. The typification of tourist clusters of the region is presented according to the criteri…
Dealing with viewers’ complaints: Role, visibility and transparency of PSB Ombudsmen in ten European countries
2017
The article shows the results of a comparative analysis of the complaints management mechanisms offered by ten European Public Service Broadcasting (PSB) systems on their corporate websites. Using a qualitative methodology, it maps the procedures and evaluates the visibility, transparency and dissemination of results. The findings show, firstly, great diversity in terms of responsible election and management, despite the converging media governance. Also noteworthy is the margin of substantial improvement in the transparency and dissemination possibilities, specially relating to the interaction offered by the digital environment. Among the ten public corporations analysed, the BBC is the be…
Identification of Energy Hubs for the Exploitation of Residual Biomass in an Area of Western Sicily
2017
Recent years have witnessed a marked reduction in financial incentives for renewable energy production in Italy as a consequence of the fact that the nation has already reached its energy policy targets for 2020, However, incentives still persist in certain sectors, such as those of specialized crops for biomass and residual biomass. In order to increase use-efficiency of biomass resources, careful study is needed of their characteristics, and their distribution within an area and over time: biomass use is of interest when production is concentrated in a given area and sufficiently available throughout the year. In order to assess the competitiveness of the biomass energy sector, the logist…
Peptide-mediated interference with baculovirus transduction
2007
Baculovirus represents a multifunctional platform with potential for biomedical applications including disease therapies. The importance of F3, a tumor-homing peptide, in baculovirus transduction was previously recognized by the ability of F3 to augment viral binding and gene delivery to human cancer cells following display on the viral envelope. Here, F3 was utilized as a molecular tool to expand understanding of the poorly characterized baculovirus-mammalian cell interactions. Baculovirus-mediated transduction of HepG2 hepatocarcinoma cells was strongly inhibited by coincubating the virus with synthetic F3 or following incorporation of F3 into viral nucleocapsid by genetic engineering, th…
Occlusion-derived baculovirus: interaction with human cells and evaluation of the envelope protein P74 as a surface display platform.
2008
To develop complementary baculovirus-based tools for gene delivery and display technologies, the interaction of occlusion-derived baculovirus (ODV) with human cells, and the functionality of the P74 ODV envelope protein for display of the IgG-binding Z domains (ZZP74) were evaluated. The cellular binding of ODV was concentration-dependent and saturable. Only minority of the bound virions were internalized at both 37 and 4 degrees C, suggesting usage of direct membrane fusion as the entry mode. The intracellular transport of ODV was confined in vesicular structures peripheral to the plasma membrane, impeding subsequent nuclear entry and transgene expression. Transduction of ODV was not rescu…