Search results for "Western"
showing 10 items of 1138 documents
Stilbenes and resveratrol metabolites improve mitochondrial fatty acid oxidation defects in human fibroblasts
2014
International audience; Background: Inborn enzyme defects of mitochondrial fatty acid beta-oxidation (FAO) form a large group of genetic disorders associated to variable clinical presentations ranging from life-threatening pediatric manifestations up to milder late onset phenotypes, including myopathy. Very few candidate drugs have been identified in this group of disorders. Resveratrol (RSV) is a natural polyphenol with anti-oxidant and anti-inflammatory effects, recently shown to have beneficial metabolic properties in mice models. Our study explores its possible effects on FAO and mitochondrial energy metabolism in human cells, which are still very little documented.Methods: Using cells …
Anza palaeoichnological site, Late Cretaceous, Morocco. Part III: Comparison between traditional and photogrammetric records
2020
11 pages; International audience; The present study evaluates a methodological workflow that could identify dinosaur tracks and trackways more comprehensively at outcrop scale. The approach described here is based both on 3D modelling by photogrammetry at different resolutions, and on suitably processed digital elevation models (DEMs). The ichnosite of Anza, Morocco, was chosen to demonstrate the efficiency of the proposed pipeline, because 323 dinosaur and pterosaur tracks discovered there have already been published. One subsector containing 89 tracks, identified in the two companion works that followed a traditional approach, was selected and divided into four subzones. By combining diff…
A genre and a limit: Across the Rio Grande border: A study of Tommy Lee Jones' 2005 film "The Three Burials of Melquiades Estrada"
2010
Attempting to answer the deceptively simple question of how far Tommy Lee Jones' 2005 film "The Three Burials of Melquiades Estrada" can be described as a western will give an opportunity to explore some features of the genre, especially the geography of the Western, as well as study a few stories set in typical landscapes, focussing on the border between the United States and Mexico. That major locus in northern as well as mid-American imagination and culture is also the setting of a number of westerns and especially of John Ford's Rio Grande (1950), the source of our title as well as a fascinating inter-text to Tommy Lee Jones' work. A post mortem western, The Three Burials of Melquiades …
"More or Less American: Sergio Leone's Vision of America in 'Once Upon a Time in the West' (1968)"
2012
This article focuses on the representation of the American West in Sergio Leone's fourth Western, which is the first to include several scenes that have been shot on location in the U.S. The author argues that Once Upon a Time in the West offers a critique not only of the classical Hollywood Westerns Leone adored, but also of his own brand of Italian Western, which may, in part, explain why members of the counter-culture were so enthused by the film at its release. The first section examines the way the use of American locations foregrounds the artificiality of Leone's spatial construction. The second explores the political implications of the inclusion of various minority groups, thereby r…
Public employees in South-Western Norway using an e-bike or a regular bike for commuting – A cross-sectional comparison on sociodemographic factors, …
2019
Large-scale analyses on the travel behavior of e-bikes are scarce, and current knowledge regarding who the e-bike owners are is inconsistent. Also, commuters represent a relevant user group with an unexploited potential. Therefore, the purpose of the present study was to examine (i) associations between type of bike (e-bike vs. regular bike) with place of residence (county), sociodemographic variables (age, sex, educational level, income and ethnicity) and habitual physical activity level, and (ii) if public employees possessing an e-bike cycle more often and longer distances to work. A cross-sectional survey was conducted in 2017 among 1977 (5.2% of eligible subjects) public employees in S…
La postérité des lois barbares
2011
What happened to the barbaric laws after the Carolingian period ? Some maintain a certain life, that does not exclude major revisions : it is the case with the Lombard law and the wisigothic law. Others, however, exist as traces, but all keep persistence, which points out their ongoing adaptation to social needs. The purpose of this paper is to update our knowledge about the forms of resistance of the barbaric laws in Western christianity from the 11th to the 13th century. Their obliteration in this period of starting construction of the modern state is neither simple nor linear ; we cannot regard it as a pure burial to the benefit of the new laws, feudal, customarily or roman as well. Actu…
Role of nitric oxide synthases from Klebsormidium nitens: structural characterization and identification of protein partners
2022
Nitric oxide (NO) is an important cellular signalling molecule regulating various physiological processes, in both animals andplants. In animals, NO synthesis is mainly catalysed by NO synthase (NOS) enzymes. During biotic or abiotic stresses, NOSlike activities that are sensitive to mammalian NOS inhibitors have been detected in plants, although no sequences encodingthe well described mammalian NOS are highlighted in land plants. Interestingly, we identified NOS-like sequences in 20 algaespecies. Among them, NOSs are found in Klebsormidium nitens the model alga to study the early transition step from aquaticalgae to land plants.As mechanisms governing NO synthesis and signalling in green l…
Segesta e il mondo greco coloniale attraverso lo studio delle anfore greco-occidentali da aree sacre: primi dati
2020
Lo studio riguarda le anfore vinarie di produzione greco-occidentale provenienti da due aree sacre di età arcaica e classica di Segesta, per le quali disponiamo di dati archeologici, sinora rimasti inediti: l’area sacra sull’Acropoli Nord documentata dal cosiddetto scarico di Grotta Vanella e il santuario extraurbano di contrada Mango. I reperti anforici sono stati studiati secondo le norme del progetto FA- CEM e sono stati attribuiti a tipologie e produzioni più o meno note. Lo studio di tali reperti inediti è stato affiancato da una revisione sistematica delle anfore greco-occidentali segestane già edite, rinvenute negli scavi stratigrafici condotti negli anni Novanta del secolo scors…
Regulation of the alpha-secretase ADAM10 by its prodomain and proprotein convertases.
2001
SPECIFIC AIMSTo identify the proprotein convertases responsible for maturation of the α-secretase ADAM10, we investigated the influence of PC7 and furin on ADAM10 processing and the resulting effect on amyloid precursor protein cleavage. We also examined the functional role of the ADAM10 prodomain by coexpression of a prodomain-deleted ADAM10 mutant together with its prodomain in trans.PRINCIPAL FINDINGS1. ADAM10 is proteolytically processed by PC7 and furinThe disintegrin metalloproteinase ADAM10 possesses α-secretase activity as well as a potential proprotein convertase recognition sequence (RKKR) after its prodomain. By amino-terminal sequencing of ADAM10 purified from bovine kidney plas…
Sea Urchin Mitochondrial Matrix Contains a 56-kDa Chaperonine-like Protein
1997
Abstract Paracentrotus lividus mitochondrial matrix contains a constitutive hsp of 56-KDa which cross reacts with a serum anti-hsp-60 chaperonine from yeast mitochondria. The localization of hsps preexisting or newly synthesized in different subcellular fractions of gastrula embryos is also analyzed by two-dimensional electrophoresis.