Search results for "Whole"

showing 10 items of 581 documents

Omega-6 and omega-3 polyunsaturated fatty acid levels are reduced in whole blood of Italian patients with a recent myocardial infarction: the AGE-IM …

2014

Abstract Objective The relationship between whole blood fatty acids and myocardial infarction (MI) risk has not been analyzed in detail, especially in Mediterranean countries. The AGE-IM (Acidi Grassi Essenziali e Infarto Miocardico) study was planned to examine the relationships between MI, whole blood fatty acids and the diet in an Italian cohort. Methods 119 Patients with a recent MI and 103 control subjects were enrolled in the study. The whole blood fatty acid composition was determined; information on anthropometrics, biochemical parameters and blood pressure values were also obtained. Diet composition was assessed using a validated food frequency questionnaire from 86 cases and 72 co…

Malemedicine.medical_specialtyInfarctionPhysiologyBlood PressureCohort StudiesFatty Acids MonounsaturatedRisk FactorsFatty Acids Omega-6Fatty Acids Omega-3MedicineHumansMyocardial infarctionWhole bloodAgedchemistry.chemical_classificationAnthropometrybusiness.industryFatty AcidsFatty acidAnthropometryMiddle Agedmedicine.diseaseSettore MED/11 - Malattie Dell'Apparato CardiovascolareSurgeryDietBlood pressurePolyunsaturated fatty acidmyocardial infarctionchemistryItalyCase-Control StudiesCohortFemaleCardiology and Cardiovascular MedicinebusinessPolyunsaturated fatty acid
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Critical limb ischaemia is characterised by an increased production of whole blood reactive oxygen species and expression of TREM-1 on neutrophils

2013

Atherosclerosis is a chronic inflammatory process involving polymorphonuclear neutrophils (PMN) and formation of reactive oxygen species (ROS). The aim of the present study was to investigate the phenotype of inflammatory cells in regard to the expression of triggering receptor expressed on myeloid cells (TREM)-1 and its soluble form (sTREM-1) as well as its relationship with oxidative stress in peripheral artery disease (PAD) patients.In total 90 patients with PAD (N = 30 intermittent claudication (IC)300 m absolute walking distance, N = 30 IC300 m absolute walking distance, N = 30 critical limb ischaemia (CLI)) and 30 control persons were included. ROS formation was measured at basal or s…

Malemedicine.medical_specialtyNeutrophilsWalkingmedicine.disease_causeMonocytesFlow cytometryPeripheral Arterial DiseaseBasal (phylogenetics)IschemiaRisk FactorsInternal medicinePrevalencemedicineHumansReceptors ImmunologicReceptorAgedWhole bloodchemistry.chemical_classificationReactive oxygen speciesMembrane Glycoproteinsmedicine.diagnostic_testbusiness.industryMiddle AgedAtherosclerosisFlow CytometryPhenotypeTriggering Receptor Expressed on Myeloid Cells-1Intermittent claudicationOxidative StressEndocrinologychemistryImmunologyDisease ProgressionFemaleEndothelium Vascularmedicine.symptomReactive Oxygen SpeciesCardiology and Cardiovascular MedicinebusinessBiomarkersOxidative stressAtherosclerosis
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Complete analysis of the epidemiological scenario around a SARS-CoV-2 reinfection: previous infection events and subsequent transmission

2021

9 páginas, 3 figuras. The data that support the findings of this study (Fastq files) are publicly available. Fastq files above the GISAID thresholds were deposited at GISAID (hCoV-19/Spain/MD-IBV-99007733/2020, hCoV-19/Spain/MD-IBV-99007151/2020, hCoV-19/Spain/MD-IBV-99007734/2020, and hCoV-19/Spain/MDIBV-99007170/2020). All sequences were also deposited at the ENA (European Nucleotide Archive; https:// www.ebi.ac.uk/ena/browser/home) (ERR5698024, ERR5697187, ERR6459974, ERR5698025, and ERR5697254).

Malemedicine.medical_specialtyPediatricsEpidemiologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)PopulationContext (language use)MicrobiologySeverity of Illness IndexreinfectionEpidemiologyMedicineHumansTransmissionFamilySeroconversioneducationMolecular BiologyPhylogenyFirst episodeeducation.field_of_studyWhole Genome Sequencingbusiness.industryTransmission (medicine)SARS-CoV-2transmissionCOVID-19GenomicsMiddle AgedQR1-502SpainReinfectionFemaleContact TracingbusinessContact tracingResearch Article
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Adaptive immune responses to SARS-CoV-2 in recovered severe COVID-19 patients

2021

ABSTRACTObjectivesThere is an imperative need to determine the durability of adaptive immunity to SARS-CoV-2. We enumerated SARS-CoV-2-reactive CD4+ and CD8+ T cells targeting S1 and M proteins and measured RBD-specific serum IgG over a period of 2-6 months after symptoms onset in a cohort of subjects who had recovered from severe clinical forms of COVID-19.MethodsWe recruited 58 patients (38 males and 20 females; median age, 62.5 years), who had been hospitalized with bilateral pneumonia, 60% with one or more comorbidities. IgG antibodies binding to SARS-CoV-2 RBD were measured by ELISA. SARS-CoV-2-reactive CD69+-expressing-IFNγ-producing-CD4+ and CD8+ T cells were enumerated in heparinize…

Malemedicine.medical_specialtyT cellsCD8-Positive T-LymphocytesAntibodies ViralGastroenterologyArticleFlow cytometryImmune systemImmunityVirologyInternal medicineHumansMedicineWhole bloodReceptor binding domain-specific IgG antibodiesmedicine.diagnostic_testbiologybusiness.industrySARS-CoV-2CD69ImmunityCOVID-19Middle AgedAcquired immune systemInfectious DiseasesCohortbiology.proteinFemaleAntibodybusinessCD8Journal of Clinical Virology
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Right atrium compression by a renal cyst: a tomographic diagnosis.

2011

Malemedicine.medical_specialtyWhole body imagingmedicinePolycystic kidney diseaseHumansCystWhole Body ImagingHeart AtriaLungPolycystic Kidney DiseasesLungbusiness.industryRight atrium compression renal cystGeneral MedicineMiddle Agedmedicine.diseaseCompression (physics)Settore MED/11 - Malattie Dell'Apparato CardiovascolareTomography x ray computedmedicine.anatomical_structureLiverRight atriumRadiologyCardiology and Cardiovascular MedicinebusinessTomography X-Ray ComputedHeart atriumJournal of cardiovascular medicine (Hagerstown, Md.)
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Dextran-sulfate-adsorption of atherosclerotic lipoproteins from whole blood or separated plasma for lipid-apheresis--comparison of performance charac…

2007

For many years dextran sulfate adsorption (DSA) treatment of separated plasma has been an established technology for low-density lipoprotein (LDL)-elimination. Recently a system for the treatment of whole blood based on DSA was introduced into clinical practice. To further characterize DSA treatment of whole blood, the performance characteristics of both DSA modalities were compared at two investigational sites with two alternative LDL apheresis systems being already in routine clinical use. In prospective cross-over design, DSA whole blood treatment was compared with a whole blood polyacrylate LDL adsorption system (DALI) in one study group. DSA for plasma treatment was compared with Lipid…

Malemedicine.medical_specialtymedicine.medical_treatmentUrologyAcrylic ResinsFibrinogenchemistry.chemical_compoundmedicineHumansWhole bloodbusiness.industryCholesterolDextran SulfateBlood Component RemovalFibrinogenHematologyGeneral MedicineCholesterol LDLHemoperfusionAtherosclerosisSurgerybody regionsApheresischemistryLDL apheresisBlood Component RemovalFemalebusinessFiltrationmedicine.drugLipoproteinJournal of clinical apheresis
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Pan-cancer analysis of whole genomes

2020

Publisher's version (útgefin grein)

Maletert promoter mutationsCancer development and immune defence Radboud Institute for Molecular Life Sciences [Radboudumc 2]DNA Mutational AnalysisNormal tissuesystematic analysisGermlineTranscriptome0302 clinical medicineAetiologyCàncerCellular SenescenceCancer0303 health sciencesdna-damageMassive parallel sequencingPan cancerREARRANGEMENTSHigh-Throughput Nucleotide SequencingGenomicsSciences bio-médicales et agricolesTelomereCOMPREHENSIVE3. Good healthTERT PROMOTER MUTATIONSsignatures030220 oncology & carcinogenesisScience & Technology - Other TopicsErfðarannsóknirHuman:Informàtica::Aplicacions de la informàtica::Bioinformàtica [Àrees temàtiques de la UPC]EvolutionRNA SplicingGenomicsArticleEvolution MolecularStructural variationRC025403 medical and health sciencesSDG 3 - Good Health and Well-beingGeneticgenomicsSYSTEMATIC ANALYSISGeneticsGenomics--Databases.HumansGenetic TestingMolecular BiologySIGNATURESWhole genome sequencing1000 MultidisciplinaryChromothripsisScience & TechnologyRC0254 Neoplasms. Tumors. Oncology (including Cancer)Information DisseminationResearchInstitutes_Networks_Beacons/mcrcPreventionBiology and Life SciencesMolecularOncogenesCloud Computingmedicine.diseaseGenòmicaCompute cloudsMutation570 Life sciences; biologyCOMPREHENSIVE CHARACTERIZATIONGenèticaWhole Genome Sequencing--methodsBackground informationDNA Mutational Analysis ; Evolution ; Genetic / genetics ; Genome ; Genomics ; Germ-Line Mutation / genetics ; High-Throughput Nucleotide Sequencing ; Human / genetics ; Humans ; ICGC/TCGA Pan-Cancer Analysis of Whole Genomes ConsortiumMedizinGenomeWhole-genomeGenome mappingNeoplasms2.1 Biological and endogenous factorsPromoter Regions GeneticCàncer -- Aspectes genèticsTelomeraseGeneticsWomen's cancers Radboud Institute for Molecular Life Sciences [Radboudumc 17]MultidisciplinaryChromothripsisGenomeManchester Cancer Research Centregenomics cancer profiling3rd-DAS10124 Institute of Molecular Life SciencesWomen's cancers Radboud Institute for Health Sciences [Radboudumc 17]Multidisciplinary SciencesParallel sequencingICGC/TCGA Pan-Cancer Analysis of Whole Genomes ConsortiumFemaleprofilingMedical GeneticsEngineering sciences. TechnologyBiotechnologyGeneral Science & TechnologyThe Cancer Genome Atlas610 Medicine & healthComputational biologyQH426 GeneticsBiologyConsortium of the International Cancer Genome ConsortiumPromoter RegionsGermline mutationPan-cancer analysisKrabbameinsrannsóknirmedicinecancerddc:610QH426Germ-Line MutationMedicinsk genetikKrabbamein030304 developmental biologyCell ProliferationLANDSCAPEGenome Humancomprehensive characterizationPan-cancer analysis of whole genomesPoint mutationHuman GenomeCancerReproducibility of ResultsSOMATIC MUTATIONSEVOLUTIONCancer sequencing Chromothripsis telomereDNA-DAMAGEMutagenesisPATTERNS3111 BiomedicineCHARACTERIZATION
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Draft genome sequence of Pseudomonas corrugata, a phytopathogenic bacterium with potential industrial applications

2014

Pseudomonas corrugata was first described as the causal agent of a tomato disease called 'pith necrosis' yet it is considered as a biological resource in various fields such as biocontrol of plant diseases and production of industrially promising microbial biopolymers (mcl-PHA). Here we report the first draft genome sequence of this species. © 2014 Elsevier B.V.

Mcl-PHAMolecular Sequence DataBiological pest controlBacterial ProteinBioengineeringPseudomonaApplied Microbiology and BiotechnologyBacterial proteinBacterial ProteinsSolanum lycopersicumBiocontrol agentPlant pathogenPseudomonasBotanyLycopersicon esculentumWhole genome sequencingBase SequencebiologyPseudomonasfood and beveragesSequence Analysis DNAGeneral Medicinebiology.organism_classificationCyclic lipopeptideQuorum sensingPseudomonas corrugataQuorum sensingPithGenome BacterialBacteriaBiotechnologyJournal of Biotechnology
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Problems Associated with the Use of Chemical Class Controls in Absence of Information on the Underlying Mechanism

1982

It is simply not possible to test all chemicals in adequately performed whole animal carcinogenicity tests. Short-term tests are, therefore, frequently used as a substitute. None of these short-term tests give results which correspond in all cases to the results obtained in whole animal carcinogenicity tests. Certain short-term tests have a notoriously poor predictibility for whole animal carcinogenicity for certain classes of chemicals. Therefore, if a chemical, whose carcinogenicity is unknown, is tested in a short-term test, frequently related compounds of known carcinogenicity are also tested simultaneously as chemical class controls.

Mechanism (biology)Carcinogenicity TestWHOLE ANIMALBiologyBioinformaticsMathematical economics
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Whole-Body Magnetic Resonance Imaging: Current Role in Patients with Lymphoma.

2021

Imaging of lymphoma is based on the use of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) and/or contrast-enhanced CT, but concerns have been raised regarding radiation exposure related to imaging scans in patients with cancer, and its association with increased risk of secondary tumors in patients with lymphoma has been established. To date, lymphoproliferative disorders are among the most common indications to perform whole-body magnetic resonance imaging (MRI). Whole-body MRI is superior to contrast-enhanced CT for staging the disease, also being less dependent on histology if compared to 18F-FDG-PET/CT. As well, it does not require exposure to i…

Medicine (General)medicine.medical_specialtydiffusion-weighted imagingClinical BiochemistryWhole body imagingLymphoproliferative disorderslymphomaReviewwhole-body imaging030218 nuclear medicine & medical imagingIonizing radiation03 medical and health sciencesR5-9200302 clinical medicinehemic and lymphatic diseasesmedicinemagnetic resonance imagingmedicine.diagnostic_testbusiness.industryCancerMagnetic resonance imagingstagingmedicine.diseaseLymphomaPositron emission tomography030220 oncology & carcinogenesisRadiologybusinessDiffusion MRIDiagnostics (Basel, Switzerland)
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