Search results for "Wild"
showing 10 items of 542 documents
Inactivation of a small heat shock protein affects cell morphology and membrane fluidity in Lactobacillus plantarum WCFS1.
2011
A small heat shock gene of Lactobacillus plantarum strain WCFS1 was deleted using a Cre-lox based system. Compared to the wild type, the ∆hsp 18.55 mutant strain displayed a similar growth rate when cultivated either under optimal temperature or under different stress conditions such as heat, low pH and salt stress. However, a longer lag phase was observed when the ∆hsp 18.55 mutant strain was cultivated under short intense heat stress (50 °C). This suggests that the hsp 18.55 gene of L. plantarum may be involved in recovery of L. plantarum stressed cells in the early stage of high temperature stress. In addition, morphology of the mutant cells, investigated by scanning electron microscopy,…
The diet of spotted cuscus (Spilocuscus maculatus) in natural and captivity habitat
2010
Saragih EW, Sadsoeitoeboen MJ, Pattiselanno F. 2010. The diet of spotted cuscus (Spilocuscus maculatus) in natural andcaptivity habitat. Nusantara Bioscience 2: 78-83. The ex-situ conservation of cuscus (Spilocuscus maculatus) under captivatingcondition is an alternative solution to protect cuscus from extinction. Diets became the main factor in order to support the domesticationprocess. Particular studies on habitat and diet of cuscus have been carried out however there is still limited information on the nutritionaspects of cuscus food. This study aimed to determine the diet type, palatability and nutrient in both natural habitat and captivatingcondition. The results indicated that there …
Multi-dimensional pattern matching with dimensional wildcards
1995
We introduce a new multi-dimensional pattern matching problem, which is a natural generalization of the on-line search in string matching. We are given a text matrix A[1: n1, ..., 1:n d ] of size N= n1×n2×...×n d , which we may preprocess. Then, we are given, online, an r-dimensional pattern matrix B[1:m1,...,1:m r ] of size M= m1×m2×...×m r , with 1≤r≤d. We would like to know whether B*=B*[*, 1:m1,*, ...,1: mr, *] occurs in A, where * is a dimensional wildcard such that B* is any d-dimensional matrix having size 1 × ... × m1×...1×m r ×...1 and containing the same elements as B. Notice that there might be (d/r)≤2d occurrences of B* for each position of A. We give CRCW-PRAM algorithms for pr…
Knock out der c-Jun N-terminalen Kinase 2 (JNK2) aggraviert die Entwicklung der chronischen DSS-Colitis unabhängig von der intestinalen Zytokin-Expre…
2008
Background The c-Jun N-terminal kinase 2 (JNK2) is involved in signal transduction of inflammatory bowel diseases (IBD) and regulates the expression of pro-inflammatory cytokines. For this reason, JNK2 is considered as novel target for IBD therapy. The aim of this study was 1.) to examine the function of JNK2 applying a low dose Dextran Sulfate Sodium (DSS) model of chronic experimental colitis in JNK2 knock out mice and 2.) to analyze the expression of JNK2 dependent cytokines. Material and Methods: For induction of a mild chronic colitis, female JNK2 knockout mice (JNK2 ko) and their wildtype controls (WT2) received three cycles of DSS treatment, each consisting of 1.0 % DSS for 5 days, f…
Wild-type JAK2 secondary acute erythroleukemia developing after JAK2-V617F-mutated primary myelofibrosis.
2009
A 54-year-old female patient developed acute erythroleukemia after an 8-year course of primary myelofibrosis. The latter harbors the JAK2-V617F mutation and was treated with hydroxyurea and anagrelide. A bone marrow trephine biopsy disclosed 2 morphologically distinct areas of chronic primary myelofibrosis and acute erythroleukemia. Microdissection and a separate molecular pathological analysis was performed. Although the activating JAK2-V617F mutation was not maintained in blasts of acute erythroleukemia, it was detectable in the chronic phase of primary myelofibrosis, indicating that this mutation did not play a role in the leukemic transformation of erythroid cells.
Assessing preferences and motivations for owning exotic pets : Care matters
2023
Understanding drivers of demand for exotic pets may help inform adequate conservation strategies to address unsustainable trade. Here, we used a best-worst scaling approach to understand the variety of preferences and motivations for owning exotic pets. Respondents (316 from 33 countries) preferred exotic pets that were captive-bred, had rare aesthetic features, and were common in the wild and abundant in the market. Species that were at risk of extinction, in short supply, sourced from the wild, and under trade restrictions were the least favoured by respondents. Feelings of care, such as attachment, affection, nurture, as well as curiosity and being passionate about the species, were domi…
Independent Generation of Aβ42 and Aβ38 Peptide Species by γ-Secretase
2008
Proteolytic processing of the amyloid precursor protein by beta- and gamma-secretase generates the amyloid-beta (Abeta) peptides, which are principal drug targets in Alzheimer disease therapeutics. gamma-Secretase has imprecise cleavage specificity and generates the most abundant Abeta40 and Abeta42 species together with longer and shorter peptides such as Abeta38. Several mechanisms could explain the production of multiple Abeta peptides by gamma-secretase, including sequential processing of longer into shorter Abeta peptides. A novel class of gamma-secretase modulators (GSMs) that includes some non-steroidal anti-inflammatory drugs has been shown to selectively lower Abeta42 levels withou…
Organophosphonate utilization by the wild‐type strain of cladosporium resinae
1997
We studied the biodegradation of compounds containing phosphorus‐to‐carbon bond by using wild‐type strain of Cladosporium resinae. The substrate specificity of the strain was studied and we found that it is able to utilize a range of structurally diverse organophosphonates as a sole source of phosphorus. This ability is inducible as indicated by the presence of a lag phase of the growth. A popular herbicide glyphosate is also degraded by the fungi. This indicates that Cladosporium resinae may play an important role in biodegradation of this herbicide. The strain which we used, however, did not metabolise any phosphonates when they served as the sole carbon or nitrogen sources.
Pianificazione per la conservazione della diversità dei progenitori selvatici delle piante coltivate e delle piante selvatiche raccolte in natura
2022
Le piante selvatiche raccolte in natura (Wild Harvested Plants - WHP) e i progenitori selvatici delle colture (Crop Wild Relatives - CWR), note collettivamente come “Risorse fitogenetiche” (PGR), rivestono molteplici ruoli di rilevanza ecologica, ambientale e socioeconomica perché ad essi si correlano numerosi usi diretti e indiretti, ma anche perché costituiscono un serbatoio di caratteri genetici potenzialmente utili per il miglioramento genetico delle piante coltivate. Ciò rende prioritaria la messa a punto di appropriate strategie di conservazione e valorizzazione. Nella presente tesi vengono presentate le attività che hanno portato alla elaborazione di due inventari delle CWR e delle W…
Substrate specificity overlap and interaction between Adrenoleukodystrophy protein (ALDP/ABCD1) and Adrenoleukodystrophy-related protein (ALDRP/ABCD2)
2011
X-linked adrenoleukodystrophy (X-ALD) is a neurodegenerative disorder caused by mutations in the ABCD1 gene, which encodes a peroxisomal member of the ATP-binding cassette (ABC) transporter subfamily D called ALDP. ALDP is supposed to function as a homodimer allowing the entry of CoA-esters of very-long chain fatty acids (VLCFA) into the peroxisome, the unique site of their β-oxidation. ALDP deficiency can be corrected by overexpression of ALDRP, its closest homolog. However, the exact nature of the substrates transported by ALDRP and its relationships with ALDP still remain unclear. To gain insight into the function of ALDRP, we used cell models allowing the induction in a dose-dependent m…