Search results for "Workflow"
showing 10 items of 133 documents
An expert system hybrid architecture to support experiment management
2014
Specific expert systems are used for supporting, speeding-up and adding precision to in silico experimentation in many domains. In particular, many experimentalists exhibit a growing interest in workflow management systems for making a pipeline of experiments. Unfortunately, these type of systems does not integrate a systematic approach or a support component for the workflow composition/reuse. For this reason, in this paper we propose a knowledge-based hybrid architecture for designing expert systems that are able to support experiment management. This architecture defines a reference cognitive space and a proper ontology that describe the state of a problem by means of three different per…
Tandem repeats lead to sequence assembly errors and impose multi-level challenges for genome and protein databases
2019
AbstractThe widespread occurrence of repetitive stretches of DNA in genomes of organisms across the tree of life imposes fundamental challenges for sequencing, genome assembly, and automated annotation of genes and proteins. This multi-level problem can lead to errors in genome and protein databases that are often not recognized or acknowledged. As a consequence, end users working with sequences with repetitive regions are faced with ‘ready-to-use’ deposited data whose trustworthiness is difficult to determine, let alone to quantify. Here, we provide a review of the problems associated with tandem repeat sequences that originate from different stages during the sequencing-assembly-annotatio…
Interruptions to workflow: Their relationship with irritation and satisfaction with performance, and the mediating roles of time pressure and mental …
2013
Understanding the mechanisms of workflow interruptions is crucial for reducing employee strain and maintaining performance. This study investigates how interruptions affect perceptions of performance and irritation by employing a within-person approach. Such interruptions refer to intruding secondary tasks, such as requests for assistance, which occur within the primary task. Based on empirical evidence and action theory, it is proposed that the occurrence of interruptions is negatively related to satisfaction with one's own performance and positively related to forgetting of intentions and the experience of irritation. Mental demands and time pressure are proposed as mediators. Data were g…
Interest of exome sequencing trio-like strategy based on pooled parental DNA for diagnosis and translational research in rare diseases.
2021
Abstract Background Exome sequencing (ES) has become the most powerful and cost‐effective molecular tool for deciphering rare diseases with a diagnostic yield approaching 30%–40% in solo‐ES and 50% in trio‐ES. We applied an innovative parental DNA pooling method to reduce the parental sequencing cost while maintaining the diagnostic yield of trio‐ES. Methods We pooled six (Agilent‐CRE‐v2–100X) or five parental DNA (TWIST‐HCE–70X) aiming to detect allelic balance around 8–10% for heterozygous status. The strategies were applied as second‐tier (74 individuals after negative solo‐ES) and first‐tier approaches (324 individuals without previous ES). Results The allelic balance of parental‐pool v…
Challenges and Opportunities using MultiChain for Real Estate
2019
The real estate market involves multiple untrusted actors with contrasting objectives. We propose REchain, a blockchain-based platform for real estate, which provides benefits to all actors in terms of transparency, trust, immutability, and traceability. REchain architecture handles real estate data through well-defined workflows that leverage the MultiChain platform. REchain changes the real estate market enabling direct transactions without intermediaries, and providing new mechanisms for negotiating the purchase conditions. This paper refutes the misleading idea of using blockchains for solving generic problems as blockchain platforms have peculiar features that make them suitable for sp…
Social support for collaboration and group awareness in life science research teams
2019
Background Next-generation sequencing (NGS) technologies have revolutionarily reshaped the landscape of ’-omics’ research areas. They produce a plethora of information requiring specific knowledge in sample preparation, analysis and characterization. Additionally, expertise and competencies are required when using bioinformatics tools and methods for efficient analysis, interpretation, and visualization of data. These skills are rarely covered in a single laboratory. More often the samples are isolated and purified in a first laboratory, sequencing is performed by a private company or a specialized lab, while the produced data are analyzed by a third group of researchers. In this scenario, …
Automated untargeted stable isotope assisted lipidomics of liver cells on high glucose shows alteration of sphingolipid kinetics
2020
Abstract Untargeted lipidomics is a powerful tool to discover new biomarkers and to understand the physiology and pathology of lipids. The use of stable isotopes as tracers to investigate the kinetics of lipids is another tool able to supply dynamic information on lipid synthesis and catabolism. Coupling the two methodology is then very appealing in the study of lipid metabolism. The main issue to face is to perform thousands of calculations in order to obtain kinetic parameters starting from the MS raw data. An automated computerized routine able to do accomplish such task is presented in this paper. We analyzed the lipid kinetics of palmitic acid (PA) in hepatoma liver cells cultured in v…
Barriers to exchanging healthcare information in inter-municipal healthcare services: a qualitative case study
2018
Abstract Background In recent years, inter-municipal cooperation in healthcare services has been an important measure implemented to meet future demographic changes in western countries. This entails an increased focus on communication and information sharing across organisational borders. Technology enables efficient and effective solutions to enhance such cooperation. However, the systems in the healthcare sector tend not to communicate with one another. There is a lack of literature focusing on communication and information sharing in inter-municipal healthcare services. The aim of this article is to investigate both the characteristics of communication and information sharing, and the f…
Integration of distributed healthcare information systems: application of CEN/TC251 ENV13606
2005
Everyday, more and more, the healthcare sector requires the exchange of healthcare information between professionals from different disciplines and institutions. To support co-operative work among health professionals and institutions it is necessary to share healthcare information about patients in a meaningful way. But, nowadays, in most hospitals the heath data is distributed across several heterogeneous and autonomous information systems whose interconnection is difficult to achieve. Integration of such system may bring about many advantages such as consistent patient health records or interdepartmental workflows. In this paper, an overview of a computing system prototype, currently und…
Digitalizing Management Accounting
2019
“Digitalization” is a term that is widely used to describe various technology-induced organizational change processes. These range from those that increase efficiency through the use of technology (e. g., digitalizing paper-based workflows, e.g. invoicing) to disruptive changes to existing business models by employing new technological possibilities (e. g., platforms such as Airbnb or Uber).