Search results for "XE"

Design, synthesis and biological evaluation of new anticancer drugs: FGFR inhibitors

2021

Fibroblast growth factor receptors (FGFRs) constitute a family of tyrosine kinases receptors (RTKs) that exert pivotal physiological functions in human embryonic and adult tissues. Hyperactivated FGFR signaling drives tumorigenesis in multiple cancer types, including lung and brain cancers. Great effort has been laid on the development of new compounds that specifically target the FGFR axis. However, cancer cell- based and microenvironmental resistance mechanisms against FGFR inhibitors often arise and are currently poorly understood. Furthermore, FGFR-targeted therapy often presents different side effects, e due to the broad biological spectrum of the FGFR signaling axis as well as to its …

Posada en valor de la pintura mural gòtica lineal a territori valencià. Un cas a descobrir: el Palau-Castell de Llutxent

2016

A note on boundary conditions for nonlinear operators

2008

We investigate boundary conditions for strict-$\psi$-contractive and $\psi$-condensing operators. We derive results on the existence of eigenvectors with positive and negative eigenvalues and we obtain fixed point theorems for classes of noncompact opera\-tors.

Welfare, Home Market Effects, and Horizontal Foreign Direct Investment

2005

We investigate the spatial distribution and organization of an imperfectly competitive industry when firms may choose to operate more than a single production unit. Focusing on a short-run setting with a fixed mass of firms, we fully characterize the spatial equilibria analytically. Comparing the equilibrium and the first-best, we show that both organizational and spatial inefficiencies may arise. In particular, when fixed costs are low enough the market outcome may well lead to overinvestment and, therefore, to too many multinationals operating from a social point of view. Furthermore, once multinationals are taken into account, the market outcome may well lead too little agglomeration.

In-beam study of the 128, 130Xe nuclei

1981

Abstract The level structure of 128,130Xe has been studied in the (α, 2nγ) and (3He, 3nγ) reactions on enriched Te targets using in-beam γ-ray spectroscopic methods. For both nuclei the existing information about positive-parity level structure was enriched and many new negative-parity two-quasiparticle states were observed. Isomeric states with the half-lives of 63 ± 12 ns in 128 Xe and 4.8 ± 0.5 ns in 130 Xe were found. For collective positive-parity states the interacting boson model, and calculations based on Bohr hamiltonian were compared with the experimental data.

Frontispiece: Recent Advances in Enantioselective Desymmetrizations of Prochiral Oxetanes

2021

Neuromuscular and cardiovascular adaptations during concurrent strength and endurance training in untrained men.

2012

This study examined the effects of concurrent strength and endurance training on neuromuscular and endurance characteristics compared to strength or endurance training alone. Previously untrained men were divided into strength (S: n=16), endurance (E: n=11) or concurrent strength and endurance (SE: n=11) training groups. S and E trained 2 times and SE 2 + 2 times a week for strength and endurance during the 21-week period. Maximal unilateral isometric and bilateral concentric forces of leg muscles increased similarly in S and SE by 20-28% (p<0.01) and improvements in isometric forces were accompanied by increases (p<0.05) of maximal muscle activation. Rate of force development of isometric …

Wireless ECG and cardiac monitoring systems: State of the art, available commercial devices and useful electronic components

2021

Abstract Wireless ElectroCardioGram (ECG) systems are employed in manifold application fields: tele-monitoring, sport applications, support to ageing people at home, fetal ECG, wearable devices and ambulatory monitoring. The presence of cables often hinders user’s free movements, alongside clinicians’ routine operations. Therefore, wireless ECG systems are desirable. This paper aims at reviewing the solutions described in the literature, besides commercially available devices and electronic components useful to setup laboratory prototypes. Several systems have been developed, different in terms of the adopted technology; when approaching the development of a wireless ECG system, some import…

Magneto-Structural Properties and Theoretical Studies of a Family of Simple Heterodinuclear Phenoxide/Alkoxide Bridged MnIIILnIII Complexes : On the …

2018

A family of MnIIILnIII strictly dinuclear complexes of general formula [MnIII(μ-L)(μ-OMe)(NO3)LnIII(NO3)2(MeOH)] (LnIII = Gd, Dy, Er, Ho) has been assembled in a one pot synthesis from a polydentate, multipocket aminobis(phenol)ligand [6,6'-{(2-(1-morpholyl)ethylazanediyl)bis(methylene)}bis(2-methoxy-4-methylphenol)], Mn(NO3)2·4H2O, Ln(NO3)3· nH2O, and NEt3 in MeOH. These compounds represent the first examples of fully structurally and magnetically characterized dinuclear MnIIILnIII complexes. Single X-ray diffraction studies reveal that all complexes are isostructural, consisting of neutral dinuclear molecules where the MnIII and LnIII metal ions, which exhibit distorted octahedral MnN2O4 …

Comparing motivational, self-regulatory and habitual processes in a computer-tailored physical activity intervention in hospital employees - protocol…

2017

Abstract Background Most people do not engage in sufficient physical activity to confer health benefits and to reduce risk of chronic disease. Healthcare professionals frequently provide guidance on physical activity, but often do not meet guideline levels of physical activity themselves. The main objective of this study is to develop and test the efficacy of a tailored intervention to increase healthcare professionals’ physical activity participation and quality of life, and to reduce work-related stress and absenteeism. This is the first study to compare the additive effects of three forms of a tailored intervention using different techniques from behavioural theory, which differ accordin…