Search results for "XL"
showing 10 items of 104 documents
Xenopus Laevis and Xenopus Tropicalis have different number of OBP genes : Xlaeobp and Xtroobp
2008
International audience
Salute e lavoro in un'ottica di genere
2017
E' stata condotta una revisione della letteratura per evidenziare quali tra le patologie lavoro-correlate esprimano differenze di sesso/genere negli outcome di salute e focalizzare i principali limiti degli studi in tale ambito. La ricerca, effettuata su PubMed mediante stringa specifica, ha identificato 4828 articoli (periodo 1997-2017) di cui 381 eleggibili ai fini della revisione (4-22% a seconda della patologia). Tra questi, il 68% hanno evidenziato differenze di sesso/genere negli outcome di salute che nella maggior parte dei casi sembrano dovute ad una diversa esposizione e/o ad una segregazione lavorativa, piuttosto che a differenze biologiche. Pochi studi tuttavia pongono tale valut…
Determinants of Board Size, Composition and Leadership
2018
Using a 14-year panel data set on the Standard and Poor’s 1500 firms, this chapter examines the trends and determinants of corporate board structure (Board size, independence and CEO duality). Our hypotheses lead to predictions that firm complexity and advising requirements, the costs of monitoring and advising, ownership structure and CEO characteristics are important determinants of board structure. Our findings provide strong empirical evidence in support of these hypotheses. We also find some evidence that the Sarbanes–Oxley Act has had an impact on board structure and its determinants.
Bcl-xL and Myeloid cell leukaemia-1 contribute to apoptosis resistance of colorectal cancer cells
2008
AIM: To explore the role of Bcl-x(L) and Myeloid cell leukaemia (Mcl)-1 for the apoptosis resistance of colorectal carcinoma (CRC) cells towards current treatment modalities. METHODS: Bcl-x(L) and Mcl-1 mRNA and protein expression were analyzed in CRC cell lines as well as human CRC tissue by Western blot, quantitative PCR and immunohistochemistry. Bcl-x(L) and Mcl-1 protein expression was knocked down or increased in CRC cell lines by applying specific siRNAs or expression plasmids, respectively. After modulation of protein expression, CRC cells were treated with chemotherapeutic agents, an antagonistic epidermal growth factor receptor (EGFR1) antibody, an EGFR1 tyrosine kinase inhibitor, …
"Table 2" of "Production properties of D0, D+, D*+ and D(s)+ in 230-GeV/c pi- and K- Cu interactions"
1992
Data fitted with the form d2sig/dxdpt**2 alpha ((1-x)**N)* EXP(-B*PT**2) using combined maximum likelihood fit to the invariant mass spectrum and the x and pt**2 distributions. The values for N and B are given here. Additional systematic errors are 10 pct for N and 3 pct for B.
"Table 1" of "Production properties of D0, D+, D*+ and D(s)+ in 230-GeV/c pi- and K- Cu interactions"
1992
Data fitted with the form d2sig/dxdpt**2 alpha ((1-x)**N)* EXP(-B*PT**2) using combined maximum likelihood fit to the invariant mass spectrum and the x and pt**2 distributions. The values for N and B are given here. Additional systematic errors are 10 pct for N and 3 pct for B.
Comparative study of T84 and T84SF human colon carcinoma cells: in vitro and in vivo ultrastructural and functional characterization of cell culture …
2005
To better understand the relationship between tumor heterogeneity, differentiation, and metastasis, suitable experimental models permitting in vitro and in vivo studies are necessary. A new variant cell line (T84SF) exhibiting an altered phenotype was recently selected from a colon cancer cell line (T84) by repetitive plating on TNF-alpha treated human endothelial cells and subsequent selection for adherent cells. The matched pair of cell lines provides a useful system to investigate the extravasation step of the metastatic cascade. Since analysis of morphological differences can be instructive to the understanding of metastatic potential of tumor cells, we compared the ultrastructural and …
Dexlansoprazole Delayed Release: Pharmacotherapy of Erosive Esophagitis and GERD
2011
Dexlansoprazole MR is a modified release formulation of the R-enantiomer of lansoprazole, which employs a novel Dual Delayed Release (DDR) technology. Pharmacokinetic studies have shown that the DDR technology provides a two peaks drug release, accuring 1–2 hours and 4–5 hours after dosing, leading to an extended duration of therapeutic plasma drug concentrations compared with conventional delayed release lansoprazole. Dexlansoprazole MR 30 and 60 mg provided superior intragastric pH control compared to that obtained with lansoprazole 15 mg and 30 mg once daily dosing. Dexlansoprazole can be taken without regard to food. The drug has been shown to be as efficacious as lansoprazole in heali…
3D-QSAR pharmacophore modeling and in silico screening of new Bcl-xl inhibitors.
2010
Bcl-2 proteins family members play several roles in tumoral proliferation: they inhibit proapoptotic activity during oncogenesis, support tumor cells survival, induce chemoresistance. The discovery of new small inhibitors of Bcl-xl represents a new frontier for cancer treatment. In this study, a 3D-QSAR pharmacophore model was developed, based on 42 biarylacylsulfonamides, and used to understand the structural factors affecting the inhibitory potency of these derivatives. Aromatic, negative charge, and hydrogen bond acceptor effects contribute to the inhibitory activity. The model was then employed as 3D search query to screen ZINC drug-like database in order to select new scaffolds. Finall…
Topology of multiplex heterogeneous networks of Hodgkin-Huxley-type of models with bistability leading to stabilization stable equilibrium
2021
The dynamics of a multiplex heterogeneous networks of oscillators is studied. Two types of very similar models based on the Hodgkin-Huxley formalism are used as the basic elements of the network: the first one demonstrates bursting oscillations; the second one manifests bistability between bursting oscillations and stable equilibrium. Multiplex networks were developed and investigated, assuming more active communication between models with bistability. Different topologies of the networks are studied. It is shown that in this case it is enough to have one element with bistability in the subnetworks in order to stabilize the equilibrium state in the entire network.