Search results for "XOS"
showing 10 items of 414 documents
Extracellular vesicles shuffling intercellular messages: for good or for bad
2015
The release of extracellular vesicles (EVs) is a highly conserved process exploited by diverse organisms as a mode of intercellular communication. Vesicles of sizes ranging from 30 to 1000. nm, or even larger, are generated by blebbing of the plasma membrane (microvesicles) or formed in multivesicular endosomes (MVEs) to be secreted by exocytosis as exosomes. Exosomes, microvesicles and other EVs contain membrane and cytosolic components that include proteins, lipids and RNAs, a composition that differs related to their site of biogenesis. Several mechanisms are involved in vesicle formation at the plasma membrane or in endosomes, which is reflected in their heterogeneity, size and composit…
Estampas de la revolución española : 19 julio de 1936
Títol pres de la coberta Relligat en espiral "Impreso por el procedimiento Offset-hueco" Text en castellà, francès i anglès
Henneguya zschokkei (Myxozoa) infection in cultured whitefish : Age-dependence, seasonality and distribution within host
2017
Whitefish (Coregonus lavaretus) is an important species for European fisheries and aquaculture. Recently, the myxosporean Henneguya zschokkei has been observed to infect the muscles of whitefish in fish farms. Plasmodia of H. zschokkei prevent marketing of the fillet and cause economic losses. The factors associated with occurrence of the parasite in fish farms have not been investigated previously. We studied age-dependence, seasonality, and within-host distribution of H. zschokkei plasmodia in farmed whitefish by examining a total of 1599 fish. Distribution of plasmodia within the fish was not uniform. When the fillet was divided into parts, the number of plasmodia was positively correlat…
Coupling of Structural Additions for the Mitigation of Seismic Response in Existing Buildings
2023
In the present paper, additions in structural steelwork are utilized for giving new life to old buildings in regions characterized by medium/high seismic hazard. Two models are here proposed, i.e.: vertical addition for masonry buildings and lateral addition for r.c. buildings. For the model of vertical addition, the connection between the masonry and steel structures is realized by means of an Intermediate Isolation System (IIS). For the model of lateral addition, an exoskeleton (EXO) is connected to the existing building by means of rigid or flexible and dissipative link. Two buildings, representative of the heterogeneous Italian building stock, are selected as case studies. Parametric an…
The Exosomes-derived EGFR Ligand Amphiregulin (AREG) is a new key player in Multiple Myeloma Bone Destruction
Il Mieloma Multiplo (MM) è caratterizzato dalla presenza di aree osteolitiche dovute alla presenza di plasmacellule (PC) neoplastiche che causano l'interruzione della normale omeostasi ossea, promuovendo l'attività degli osteoclasti (OC) ed inibendo la funzione degli (OB). Al momento, uno dei campi di ricerca nella fisiopatologia del MM è proprio lo studio dei meccanismi che regolano l’attività degli OC e degli OB così come l’identificazione di target terapeutici per la prevenzione ed il trattamento delle lesioni osteolitiche. Negli ultimi anni è emerso che le vescicole extracellulari (EV), ed in particolare gli esosomi, giocano un ruolo fondamentale nel mediare il cross-talk tra le cellule…
Role of exosomes released by chronic myelogenous leukemia cells in angiogenesis
2011
HSP70 inhibition : a new therapeutic target against cancer
2013
Heat shock proteins (HSPs) were first discovered in Drosophila by Ritossa in 1962. As stress proteins, HSPs are induced in response to a wide variety of physiological and environmental insults. HSPs have a cyto-protective function and act as molecular chaperones by assisting the folding of nascent or misfolded proteins and by preventing their aggregation. Mammalian HSPs have been classified into 5 families according to their molecular weight: HSP110, HSP90, HSP70, HSP60 and the family of small HSPs such as HSP27 (Kampinga et al., 2009). The most well-known inducible stress chaperone HSP70 is hardly detectable at basal level in normal “non-stressed” cells, but in cancer cells HSP70 is consti…