Search results for "XY"

showing 10 items of 13736 documents

Carboxylate catalyzed isomerization of β,γ‐unsaturated N-acetylcysteamine thioesters

2022

We demonstrate herein the capacity of simple carboxylate salts – tetrametylammonium and tetramethylguanidinium pivalate – to act as catalysts in the isomerization of β,γ-unsaturated thioesters to α,β-unsaturated thioesters. The carboxylate catalysts gave reaction rates comparable to those obtained with DBU, but with fewer side reactions. The reaction exhibits a normal secondary kinetic isotope effect ( k 1H / k 1D = 1.065±0.026) with a β,γ−deuterated substrate. Computational analysis of the mechanism provides a similar value ( k 1H / k 1D = 1.05) with a mechanism where γ-reprotonation of the enolate intermediate is rate determining. peerReviewed

thioesterskatalyytitkinetic isotope effectsisomeriakatalyysirikkiyhdisteetcarboxylatesreaction mechanismreaktiomekanismitbase catalysisisomerizationenolatesorgaaniset yhdisteet
researchProduct

Protein tyrosine nitration and thiol oxidation by peroxynitrite-strategies to prevent these oxidative modifications.

2013

The reaction product of nitric oxide and superoxide, peroxynitrite, is a potent biological oxidant. The most important oxidative protein modifications described for peroxynitrite are cysteine-thiol oxidation and tyrosine nitration. We have previously demonstrated that intrinsic heme-thiolate (P450)-dependent enzymatic catalysis increases the nitration of tyrosine 430 in prostacyclin synthase and results in loss of activity which contributes to endothelial dysfunction. We here report the sensitive peroxynitrite-dependent nitration of an over-expressed and partially purified human prostacyclin synthase (3.3 μM) with an EC50 value of 5 μM. Microsomal thiols in these preparations effectively co…

thiol oxidationprotein tyrosine nitrationlcsh:Chemistrychemistry.chemical_compoundCytochrome P-450 Enzyme SystemSf9 CellsTyrosinelcsh:QH301-705.5Spectroscopychemistry.chemical_classification0303 health sciencesbiologySuperoxide030302 biochemistry & molecular biologyGeneral MedicineComputer Science ApplicationsIntramolecular OxidoreductasesBiochemistryThiolprostacyclin synthasesuperoxideOxidation-ReductionPeroxynitriteOxidative phosphorylationSpodopteraCatalysisArticleperoxynitriteNitric oxideProstacyclin synthaseInorganic Chemistry03 medical and health sciencesnitric oxideddc:570NitrationPeroxynitrous AcidAnimalsHumansSulfhydryl CompoundsPhysical and Theoretical ChemistryMolecular Biology030304 developmental biologyOrganic Chemistrynitric oxide; superoxide; peroxynitrite; protein tyrosine nitration; thiol oxidation; peroxynitrite scavengers; prostacyclin synthasechemistrylcsh:Biology (General)lcsh:QD1-999biology.proteinTyrosineCattleperoxynitrite scavengersProtein Processing Post-TranslationalInternational journal of molecular sciences
researchProduct

Rhizoctonia solani AG5 and Its Offspring – Morphology and Sensitivity to Fungicides

2022

The objective of these studies was to identify differences and similarities within the progeny of Rhizoctonia solani AG5, which arose from basidiospores produced by the maternal strain ID23. The following characteristics were analyzed: appearance of the mycelium (color, structure, zonation, and presence of sclerotia), growth rate (at 10°C, 20°C, and 30°C), fungicide sensitivity, and hyphal structure. The mycelial color of R. solani AG5 ranged from white/cream to light and dark brown. The structure of the mycelium may be compacted or flattened with visible zoning or fluffy with dark brown sclerotia on the colony surface. Homokaryons and heterokaryons derived from homokaryons were analyzed by…

thiophanate-methylRhizoctonia solanibasidiosporeazoxystrobinprogeny; morphologyhyphaefungicidesthiuramActa Mycologica
researchProduct

Qualitative analysis of housing demand using Google trends data

2019

Big data analytics often refer to the breakdown of huge amounts of data into a more readable and useful format. This study utilises Google Trends big data as a proxy for an analysis of housing demand. We employ a qualitative method (fuzzy set/Qualitative Comparative Analysis, fsQCA), instead of a quantitative method, for our estimate and forecast. The empirical results show that fsQCA successfully forecasts seasonal time series, even though the dataset is small in size. Our findings fill the gap in the qualitative and time series forecasting literature, and the forecasting procedure herein also offers a good standard for industry.

time series modelshousing demandEconomics and Econometricsbusiness.industryComputer scienceSèries temporals AnàlisiBig datalcsh:Regional economics. Space in economicsData sciencelcsh:HD72-88lcsh:HT388Proxy (climate)lcsh:Economic growth development planningQualitative analysisTime series models; qualitative forecasting; housing demandbusinessqualitative forecastingEconomic Research-Ekonomska Istraživanja
researchProduct

CCDC 1449803: Experimental Crystal Structure Determination

2017

Related Article: M. Saccone, A. Siiskonen, F. Fernandez-Palacio, A. Priimagi, G. Terraneo, G. Resnati, P. Metrangolo|2017|Acta Crystallogr.,Sect.B:Struct.Sci.,Cryst.Eng. and Mat.|73|227|doi:10.1107/S2052520617003444

trans-1-[4-(dodecyloxy)phenyl]-2-(2356-tetrafluoro-4-iodophenyl)diazeneSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
researchProduct

CCDC 145029: Experimental Crystal Structure Determination

2001

Related Article: G.Haufe, T.C.Rosen, O.G.J.Meyer, R.Frohlich, K.Rissanen|2002|J.Fluorine Chem.|114|189|doi:10.1016/S0022-1139(02)00040-4

trans-2-Fluoro-2-phenylcyclopropanecarboxylic acidSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
researchProduct

Las movilizaciones sociales en el espacio posyugoslavo: Oportunidades políticas y estrategias contenciosas

2021

Esta tesis pretende describir el escenario de movilizaciones sociales que caracteriza al espacio posyugoslavo, a través de las oportunidades políticas que activan las protestas y de las estrategias contenciosas que los organizadores desarrollan para articular la movilización. El estudio busca clarificar los retos de las transiciones locales, marcadas por el fin del autoritarismo yugoslavista, las transformaciones socio- económicas, la fragmentación del Estado yugoslavo y las guerras que asolaron la región entre 1991 y 2001. La investigación aborda el análisis de los nacionalismos locales como resultado de las crisis del Estado yugoslavo. Se plantea un estudio más profundo a partir de mayo (…

transicion:CIENCIA POLÍTICA [UNESCO]UNESCO::CIENCIA POLÍTICAexyugoslaviasociedad civilmovimientos socialesprotestas
researchProduct

Sintesi di complessi metallici e studio della loro interazione con acido desossiribonucleico.

2011

transition metal complexes; deoxyribonucleic acid.transition metal complexeSettore CHIM/03 - Chimica Generale E Inorganicadeoxyribonucleic acid.
researchProduct

Double copies of blaKPC-3::Tn4401a on an IncX3 plasmid in Klebsiella pneumoniae successful clone ST512 from Italy

2015

ABSTRACT A carbapenem-resistant sequence type 512 (ST512) Klebsiella pneumoniae carbapenemase 3 (KPC-3)-producing K. pneumoniae strain showing a novel variant plasmid content was isolated in Palermo, Italy, in 2014. ST512 is a worldwide successful clone associated with the spread of bla KPC genes located on the IncFIIk pKpQIL plasmid. In our ST512 strain, the bla KPC-3 gene was unusually located on an IncX3 plasmid, whose complete sequence was determined. Two copies of bla KPC-3 ::Tn 4401a caused by intramolecular transposition events were detected in the plasmid.

transposonsequence analysispolymerase chain reactionDrug ResistanceGene DosageSettore MED/42 - Igiene Generale E Applicatabacterial proteinbeta-Lactamaseopen reading framecarbapenemasePlasmidminocyclineplasmid DNAmeropenemPharmacology (medical)geneticscolistincefpodoximeceftazidime610 Medicine & healthCarbapenemBacterialpolymyxin Btimentingene expression regulationbacteriumKlebsiella pneumoniae carbapenemase 3 producing Klebsiella pneumoniae3. Good healthantiinfective agentmicrobial sensitivity testKlebsiella pneumoniaeItalypriority journaltigecyclineMultipleclone (Java method)cefotaxime030106 microbiologyKlebsiella pneumoniae carbapenemase 3tobramycinMicrobial Sensitivity Testsgentamicinpiperacillin plus tazobactamchemistryGene dosageArticleMicrobiology03 medical and health sciencesComplete sequenceClone CellOpen Reading FramesertapenemBacterial Proteinsmultidrug resistanceextensively drug resistant bacteriumAnti-Bacterial AgentcefepimePharmacologylevofloxacinmicrobiologycefoxitinbiochemical phenomena metabolism and nutritionbacterial infections and mycosesVirologyAnti-Bacterial Agents; Bacterial Proteins; Carbapenems; Clone Cells; Drug Resistance Multiple Bacterial; Gene Dosage; Italy; Klebsiella Infections; Klebsiella pneumoniae; Microbial Sensitivity Tests; Open Reading Frames; Plasmids; beta-Lactamases; DNA Transposable Elements; Gene Expression Regulation Bacterial; Pharmacology (medical); Pharmacology; Infectious Diseasesantibiotic sensitivityClone CellsKlebsiella InfectionsceftriaxoneCarbapenemsbacterial genetics0301 basic medicinemolecular cloningSettore MED/07 - Microbiologia E Microbiologia ClinicaKlebsiella pneumoniaeTransposition (music)Drug Resistance Multiple Bacterialpolycyclic compoundsgenetic screeningcell clonecarbapenem derivativeKlebsiella infectionunclassified drugAnti-Bacterial AgentsInfectious Diseasesbacterial genePlasmidsenzymologydoripenemBiologyminimum inhibitory concentrationbeta-Lactamasesbeta lactamaseMechanisms of ResistanceciprofloxacinAmikacin; aztreonam; carbapenemase; cefepime; cefotaxime; cefoxitin; cefpodoxime; ceftazidime; ceftriaxone; ciprofloxacin; colistin; cotrimoxazole; doripenem; doxycycline; ertapenem; gentamicin; imipenem; Klebsiella pneumoniae carbapenemase 3; levofloxacin; meropenem; minocycline; piperacillin plus tazobactam; plasmid DNA; polymyxin B; tigecycline; timentin; tobramycin; unclassified drug; antiinfective agent; bacterial protein; beta lactamase; carbapenem derivative; transposon antibiotic sensitivity; Article; bacterial gene; bacterial genetics; bacterial strain; bacterium; bacterium detection; bacterium isolation; Escherichia coli; extensively drug resistant bacterium; gene dosage; genetic screening; Italy; Klebsiella pneumoniae; Klebsiella pneumoniae carbapenemase 3 producing Klebsiella pneumoniae; minimum inhibitory concentration; molecular cloning; nonhuman; polymerase chain reaction; priority journal; sequence analysis; cell clone; chemistry; drug effects; enzymology; gene expression regulation; genetics; isolation and purification; Klebsiella infection; Klebsiella pneumoniae; metabolism; microbial sensitivity test; microbiology; multidrug resistance; open reading frame; plasmid; transposon Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamases; Carbapenems; Clone Cells; DNA Transposable Elements; Drug Resistance Multiple Bacterial; Gene Dosage; Gene Expression Regulation Bacterial; Italy; Klebsiella Infections; Klebsiella pneumoniae; Microbial Sensitivity Tests; Open Reading Frames; Plasmidsplasmidbacterium isolationEscherichia coliGeneAmikacinbacterium detectionnonhumandoxycyclineisolation and purificationGene Expression Regulation Bacterialbiology.organism_classificationbacterial straincotrimoxazoleOpen reading frameDNA Transposable Elementdrug effectsDNA Transposable Elementsmetabolismaztreonamimipenem
researchProduct

A Band Model of Cambium Development: Opportunities and Prospects

2021

More than 60% of tree phytomass is concentrated in stem wood, which is the result of periodic activity of the cambium. Nevertheless, there are few attempts to quantitatively describe cambium dynamics. In this study, we develop a state-of-the-art band model of cambium development, based on the kinetic heterogeneity of the cambial zone and the connectivity of the cell structure. The model describes seasonal cambium development based on an exponential function under climate forcing which can be effectively used to estimate the seasonal cell production for individual trees. It was shown that the model is able to simulate different cell production for fast-, middle- and slow-growing trees under …

tree-ring widthXylemForestryindividual treeRadiative forcingsimulationExplained variationAtmospheric sciencesTree (graph theory)Carbon cyclecambium activitycell productionEnvironmental scienceCell structurecambium bandcommon climate signalQK900-989CambiumPlant ecologyForests
researchProduct