Search results for "XYZ"
showing 6 items of 6 documents
Evaluation of enantioselective binding of antihistamines to human serum albumin by ACE.
2007
The drug binding to plasma and tissue proteins is a fundamental factor in determining the overall pharmacological activity of a drug. HSA, together with alpha(1)-acid glycoprotein, are the most important plasma proteins, which act as drug carriers, with implications on the pharmacokinetic of drugs. Among plasma proteins, HSA possesses the highest enantioselectivity. In this paper, a new methodology for the study of enantiodifferentiation of chiral drugs with HSA is developed and applied to evaluate the possible enantioselective binding of four antihistamines: brompheniramine, chlorpheniramine, hydroxyzine and orphenadrine to HSA. This study includes the determination of affinity constants o…
Heavy quark spin symmetry and SU(3)-flavour partners of the X (3872)
2013
In this work, an Effective Field Theory (EFT) incorporating light SU(3)-flavour and heavy quark spin symmetries is used to describe charmed meson-antimeson bound states. At Lowest Order (LO), this means that only contact range interactions among the heavy meson and antimeson fields are involved. Besides, the isospin violating decays of the X(3872) will be used to constrain the interaction between the D and a (D) over bar* mesons in the isovector channel. Finally, assuming that the X(3915) and Y(4140) resonances are D* (D) over bar* and D-s* (D) over bar (s)* molecular states, we can determine the four Low Energy Constants (LECs) of the EFT that appear at LO and, therefore, the full spectrum…
Evaluation of enantioselective binding of basic drugs to plasma by ACE.
2007
The present paper deals with the evaluation of the stereoselective binding of antihistamines (brompheniramine, chlorpheniramine, hydroxyzine, orphenadrine and phenindamine), phenothiazines (promethazine and trimeprazine) and a local anesthetic (bupivacaine) to human plasma proteins. Since all of them are drugs highly bound to proteins, a methodology to determine the bound fraction of each drug enantiomer was proposed. This methodology includes the incubation of samples containing plasma and racemic drug, ultrafiltration of the mixture and the chiral separation of enantiomers in the bound drug fraction using affinity EKC (AEKC)-partial filling technique and HSA as chiral selector. The result…
CCDC 2004421: Experimental Crystal Structure Determination
2020
Related Article: Zijie Qiu, Sobi Asako, Yunbin Hu, Cheng-Wei Ju, Thomas Liu, Loïc Rondin, Dieter Schollmeyer, Jean-Sébastien Lauret, Klaus Müllen, Akimitsu Narita|2020|J.Am.Chem.Soc.|142|14814|doi:10.1021/jacs.0c05504
CCDC 2021692: Experimental Crystal Structure Determination
2020
Related Article: Zijie Qiu, Sobi Asako, Yunbin Hu, Cheng-Wei Ju, Thomas Liu, Loïc Rondin, Dieter Schollmeyer, Jean-Sébastien Lauret, Klaus Müllen, Akimitsu Narita|2020|J.Am.Chem.Soc.|142|14814|doi:10.1021/jacs.0c05504
Solution of XXZ and XYZ spin chains with boundaries by separation of variables
2014
In this thesis we give accounts on the solution of the open XXZ and XYZ quantum spin-1/2 chains with the most generic integrable boundary terms. By using the the Separation of Variables method (SoV), due to Sklyanin, we are able, in the inhomogeneous case, to build the complete set of eigenstates and the associated eigenvalues. The characterization of these quantities is made through a maximal system of N quadratic equations, where N is the size of the chain. Different methods, like the Algebraic Bethe ansatz (ABA) or other generalized Bethe ansatz techniques, have been used, in the past, in order to tackle these problems. None of them resulted effective in the reproduction of the full set …