Search results for "YY1AP"

showing 2 items of 2 documents

Altered Yin Yang 1/RAF-1 kinase inhibitory protein ratio as a possible molecular marker and therapeutic target in hepatocellular carcinoma

2010

Settore MED/12 - GastroenterologiaSettore BIO/14 - FarmacologiaYY1YY1APRKIPHCC
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Yin Yang 1 and raf-1 Kinase Inhibitory Protein Status in Hepatocellular carcinoma: Future Perspectives

2010

We focus on to the role of the transcription factors NF-κB and Yin Yang 1 (YY1) and of Raf-1 kinase inhibitory protein (RKIP) in hepatocellular carcinoma (HCC). YY1, whose expression is enhanced by NF-κB, favors tumorigenesis. RKIP inhibits the oncogenic activities of MAPK and NF-κB pathways and promotes drug-induced apoptosis. Mutual influences between YY1 and RKIP may exist and there is separate evidence that relevant increases in YY1 and reductions in RKIP occur in HCC. In a recent study on clinical HCC, we found that, indeed, the ratio of YY1 to RKIP mRNA and protein expression is very frequently profoundly inverted in tumors compared with adjacent tissues. Hyperactivation of YY1 in tum…

SorafenibSettore MED/12 - GastroenterologiaHepatocellular carcinoma Yin Yang 1 RKIP YY1AP NF-kB Sorafenibbusiness.industryInhibitory postsynaptic potentialmedicine.diseaseBiochemistryYIN-YANG-1Hepatocellular carcinomaRaf 1 kinaseSettore BIO/14 - FarmacologiaGeneticsmedicineCancer researchMolecular MedicinebusinessBiotechnologymedicine.drugForum on Immunopathological Diseases and Therapeutics
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