Search results for "ZOL"

showing 10 items of 4792 documents

CCDC 275693: Experimental Crystal Structure Determination

2007

Related Article: G.Daidone, B.Maggio, M.V.Raimondi, G.Bombieri, N.Marchini, R.Artali|2005|Heterocycles|65|2753|doi:10.3987/COM-05-10499

3-Methyl-4-diazo-5-benzamidopyrazoleSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates

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X-Ray characterization of 3-methyl-6,8-di(2-pyridyl)-[1,2,3]triazolo[5′,1′:6,1]pyrido[2,3-d]pyrimidine

2005

The structure of a new compound 3-methyl-6,8-di(2-pyridyl)[1,2,3]triazolo[5′,1′:6,1]pyrido[2,3- d]pyrimidine 3, formed in the reaction of 3-methyl-[1,2,3]triazolo[1,5-a]pyridine with 2-cyanopyridine, is determined by X-ray diffraction analysis. Abarca Gonzalez, Belen. Belen.Abarca@uv.es ; Ballesteros Campos, Rafael, Rafael.Ballesteros@uv.es ; Chadlaoui, Mimoun, michad@alumni.uv.es ; Ramirez de Arellano Sanchez, Maria del Carmen, Ramirezdearellano@uv.es

3-Methyl-68-di(2-pyridyl)[123]triazolo[5′1′:61]pyrido[23-d]pyrimidine ; X-ray diffraction ; structureUNESCO::QUÍMICA:QUÍMICA::Química orgánica [UNESCO]structureUNESCO::QUÍMICA::Química orgánica:QUÍMICA [UNESCO]61]pyrido[23-d]pyrimidine [3-Methyl-68-di(2-pyridyl)[123]triazolo[5′1′]X-ray diffraction

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SYNTHESIS AND ANTIPROLIFERATIVE ACTIVITY OF 3-AMINO-N-PHENYL-1H-INDAZOLE-1-CARBOXAMIDES

2010

Recently our research group has reported the synthesis of some 3-amino-N-phenyl-1H-indazole-1-carboxamides able to inhibit at low micromolar concentrations the cell growth of many neoplastic cell lines. The above compounds are unsubstituted in the indazole nucleus and this gives the hope to obtain more active compounds if appropriate substituents are beared by the above nucleus. So, several new N-phenyl-1H-indazole-1-carboxamides 1c-h and 4l,m were prepared by reacting phenyl isocyanates 3a,b with 3-amino-1H-indazoles 2c,e,g, or 1H-indazole 2l respectively. Chemical trasformations of compounds 1a,b and 1g,h gave 3-acetamido-N-phenyl-1H-indazole-1-carboxamides 5a,b, and 3,5-diamino-N-phenyl-…

3-amino-N-phenyl-1H-indazole-1-carboxamides antiproliferative activitySettore CHIM/08 - Chimica Farmaceutica

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CCDC 1482405: Experimental Crystal Structure Determination

2020

Related Article: Ville K. Saarnio, Kirsi Salorinne, Visa P. Ruokolainen, Jesper R. Nilsson, Tiia-Riikka Tero, Sami Oikarinen, L. Marcus Wilhelmsson, Tanja M. Lahtinen, Varpu S. Marjomäki|2020|Dyes Pigm.|177|108282|doi:10.1016/j.dyepig.2020.108282

3-methyl-2-((2-(methylsulfanyl)-1-phenylquinolin-4(1H)-ylidene)methyl)-13-benzoxazol-3-ium chloride methanol solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates

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CCDC 2097024: Experimental Crystal Structure Determination

2021

Related Article: Anni I. Taponen, Awatef Ayadi, Manu K. Lahtinen, Itziar Oyarzabal, Sébastien Bonhommeau, Mathieu Rouzières, Corine Mathonière, Heikki M. Tuononen, Rodolphe Clérac, Aaron Mailman|2021|J.Am.Chem.Soc.|143|15912|doi:10.1021/jacs.1c07468

3-methylpyridinium-1235-dithiadiazolyl radical cation 77'88'-tetracyanoquinodimethane radical anion propanenitrile solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates

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CCDC 2097023: Experimental Crystal Structure Determination

2021

3-methylpyridinium-1235-dithiadiazolyl radical cation 77'88'-tetracyanoquinodimethane radical anionSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates

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CCDC 2051973: Experimental Crystal Structure Determination

2021

Related Article: Jan Sietmann, Mike Ong, Christian Mück-Lichtenfeld, Constantin G. Daniliuc, Johannes M. Wiest|2021|Angew.Chem.,Int.Ed.|60|9719|doi:10.1002/anie.202100642

3-phenyl-3'3'a8'8'a-tetrahydrospiro[cyclobutane-12'-indeno[12-d][13]oxazole]Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates

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Antidiabetic Drugs in NAFLD: The Accomplishment of Two Goals at Once?

2018

Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common cause of chronic liver disease in Western countries, accounting for 20–30% of general population and reaching a prevalence of 55% in patients with type 2 diabetes mellitus (T2DM). Insulin resistance plays a key role in pathogenic mechanisms of NAFLD. Many drugs have been tested but no medications have yet been approved. Antidiabetic drugs could have a role in the progression reduction of the disease. The aim of this review is to summarize evidence on efficacy and safety of antidiabetic drugs in patients with NAFLD. Metformin, a biguanide, is the most frequently used drug in the treatment of T2DM. To date 15 randomized controlled t…

3003medicine.medical_specialtymedicine.drug_classmedicine.medical_treatmentlcsh:Medicinelcsh:RS1-441Pharmaceutical Sciencehepatic cirrhosis030209 endocrinology & metabolismReviewChronic liver diseaseGastroenterologylcsh:Pharmacy and materia medica03 medical and health sciences0302 clinical medicineInsulin resistanceInternal medicineDiabetes mellitusDrug DiscoverymedicineBiguanidebusiness.industryLiraglutideInsulinlcsh:RFatty liverThiazolidinedionenutritional and metabolic diseasesnon-alcoholic fatty liver diseaseLiraglutidemedicine.diseaseMetforminMetforminHepatic cirrhosiMolecular Medicine030211 gastroenterology & hepatologyThiazolidinedionesnon-alcoholic steatohepatitisbusinessNon-alcoholic steatohepatitimedicine.drugPharmaceuticals (Basel, Switzerland)

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CCDC 1437668: Experimental Crystal Structure Determination

2015

Related Article: M. Akhazzane, G. Al Houari, M. El Yazidi, M. Saadi, L. El Ammari|2015|Acta Crystallogr.,Sect.E:Cryst.Commun.|71|o981|doi:10.1107/S2056989015022033

4'-(4-methoxyphenyl)-44-dimethyl-3'-(4-methylphenyl)-34-dihydro-1H4'H-spiro[naphthalene-25'-[12]oxazol]-1-oneSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates

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CCDC 1537522: Experimental Crystal Structure Determination

2017

Related Article: Pankaj Chauhan, Suruchi Mahajan, Uğur Kaya, Anssi Peuronen, Kari Rissanen, and Dieter Enders|2017|J.Org.Chem.|82|7050|doi:10.1021/acs.joc.7b01113

4'-[(t-butoxycarbonyl)amino]-33'-dimethyl-5'-oxo-11'-diphenyl[4'5'-dihydro-1H1'H-[44'-bipyrazole]]-5-yl acetateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates

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