Search results for "ZOL"

showing 10 items of 4792 documents

Perspectives for the Treatment of Brucellosis in the 21st Century: The Ioannina Recommendations

2007

Policy Forum. Competing interests: ER has received research grants from Daiichi, Bayer, and Theravance and has served as a consultant to Pfizer, Theravance, Bayer, Wyeth, Rosetta, and BiondVax. Summary Points Brucellosis remains the commonest anthropozoonosis worldwide, and its treatment remains complex, requiring protracted administration of more than one antibiotic. In November 2006, a consensus meeting aimed at reaching a common specialist statement on the treatment of brucellosis was held in Ioannina, Greece under the auspices of the International Society of Chemotherapy and the Institute of Continuing Medical Education of Ioannina. The author panel suggests that the optimal treatment o…

:Diseases::Pathological Conditions Signs and Symptoms::Pathologic Processes::Disease Attributes::Recurrence [Medical Subject Headings]Veterinary medicine:Chemicals and Drugs::Carbohydrates::Glycosides::Aminoglycosides::Streptomycin [Medical Subject Headings]:Phenomena and Processes::Microbiological Phenomena::Drug Resistance Microbial [Medical Subject Headings]DiseaseGlobal Health:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]:Health Care::Population Characteristics::Health::World Health [Medical Subject Headings]Terminología como AsuntoBrucellosi:Organisms::Eukaryota::Animals [Medical Subject Headings]:Health Care::Health Care Economics and Organizations::Organizations::International Agencies::United Nations::World Health Organization [Medical Subject Headings]Policy ForumMedicine in Developing CountriesGentamicinasDrug Resistance MicrobialBrucelosisAdhesión a DirectrizGeneral MedicineHumanosDrug CombinationsAntibacterianosDoxycyclineStreptomycinEstreptomicinaMedicine:Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds with 4 or More Rings::Rifamycins::Rifampin [Medical Subject Headings]Drug Therapy CombinationGuideline AdherenceRifampinFluoroquinolonesSalud Mundialmedicine.medical_specialtyEfficacyResultado del TratamientoInvestigación BiomédicaRecurrenciaTherapeuticsWorld Health OrganizationMicrobiologyAntibiotic resistanceTerminology as Topic:Disciplines and Occupations::Social Sciences::Internationality::International Cooperation::Developing Countries [Medical Subject Headings]HumansMedical journalIntensive care medicineDeveloping Countries:Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds 1-Ring::Pyrimidines::Trimethoprim::Trimethoprim-Sulfamethoxazole Combination [Medical Subject Headings]medicine.diseaseCotrimoxazoleAnimalesQuimioterapia:Humanities::Humanities::History::History Modern 1601-::History 21st Century [Medical Subject Headings]GentamicinsBrucel·losiBiomedical ResearchCommunicable diseases:Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds 2-Ring::Quinolines::Quinolones::Fluoroquinolones [Medical Subject Headings]Human diseaseRecurrence:Chemicals and Drugs::Pharmaceutical Preparations::Drug Combinations [Medical Subject Headings]:Information Science::Information Science::Communication::Language::Linguistics::Terminology as Topic [Medical Subject Headings]biologyIraqi patientsRMetaanalysis:Diseases::Bacterial Infections and Mycoses::Bacterial Infections::Gram-Negative Bacterial Infections::Brucellosis [Medical Subject Headings]Historia del Siglo XXIAnti-Bacterial AgentsCombinación Trimetoprim-SulfametoxazolTreatment OutcomeInfectious Diseases:Disciplines and Occupations::Natural Science Disciplines::Science::Research::Biomedical Research [Medical Subject Headings]:Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons Cyclic::Hydrocarbons Aromatic::Polycyclic Hydrocarbons Aromatic::Naphthacenes::Tetracyclines::Doxycycline [Medical Subject Headings]Fluoroquinolonas:Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Anti-Bacterial Agents [Medical Subject Headings]:Chemicals and Drugs::Carbohydrates::Glycosides::Aminoglycosides::Gentamicins [Medical Subject Headings]Países en Desarrollo:Analytical Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Drug Therapy Combination [Medical Subject Headings]BrucellaHistory 21st CenturyBrucellosisWorld healthTrimethoprim Sulfamethoxazole Drug CombinationmedicineAnimals:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis::Treatment Outcome [Medical Subject Headings]Resistencia a Medicamentosbusiness.industryOrganización Mundial de la SaludBrucellosisMalalties infecciosesTerapèuticabiology.organism_classificationCombinación de MedicamentosDoxiciclinaTherapybusinessBrucella melitensisPLoS Medicine
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Latvijas Vēstures Institūta Žurnāls. 2021, Nr. 1 (113)

2021

LU Latvijas vēstures institūta LU ilgtermiņa saistību izpilde 2020.-2022. g. ("Latvijas Vēstures Institūta Žurnāls")

:HUMANITIES and RELIGION::History and philosophy subjects::Archaeology subjects [Research Subject Categories]Vēsturisko ozolkoku dendrohronoloģiskās datēšanas pirmie rezultāti:HUMANITIES and RELIGION::History and philosophy subjects::History subjects [Research Subject Categories]RecenzijasZinātnes dzīveVēstures avotiVidzemes muižniecības un luterāņu garīdzniecības vīzija par zemnieku kārtas izglītošanuRīgas monetārā vēsture Polijas-Lietuvas kundzības laikāLatvijas iedzīvotājs - Spānijas pilsoņu kara dalībnieks
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[1,2,3]Triazolo[1,5-a]piridinas y compuestos relacionados : aplicaciones en química supramolecular : actividad biológica

2013

Los heterociclos nitrogenados son moléculas clave dentro de numerosos campos científicos. En concreto, los triazoles han encontrado numerosas aplicaciones en química médica como antifúngicos (fluconazol, posaconazol), antidepresivos (trazodona) o anticancerígenos (triazoloacridonas). En este contexto se decidió sintetizar nuevos derivados de [1,2,3]triazolo[1,5-a]piridinas con el fin de explorar su capacidad de interaccionar con ADN y su actividad leishmanicida y antichagásica. Con este objetivo se ha utilizado la química clásica de las triazolopiridinas (reacción de litiación regioselectiva de este heterociclo, seguida de adición de un electrófilo), para obtener nuevos derivados con estruc…

:QUÍMICA::Química orgánica::Mecanismos de reacción [UNESCO]:QUÍMICA::Química Farmacéutica::Diseño.Síntesis y estudio nuevos fármacos [UNESCO]heterociclos nitrogenadosleishmanicidal agentUNESCO::QUÍMICA::Química Farmacéutica::Diseño.Síntesis y estudio nuevos fármacosquinolinasUNESCO::QUÍMICA::Química orgánica::Mecanismos de reacciónUNESCO::QUÍMICA:QUÍMICA::Química orgánica [UNESCO]antichagasic agentcicloadición 13-dipolarDNA:QUÍMICA [UNESCO]oligocarbonilpiridinaUNESCO::QUÍMICA::Bioquímica::Acidos nucleicosazahelicenos:QUÍMICA::Química orgánica::Compuestos heterocíclicos [UNESCO]:QUÍMICA::Bioquímica::Acidos nucleicos [UNESCO]triazolopiridinasUNESCO::QUÍMICA::Química orgánica::Compuestos heterocíclicostransferencia de hidrógenoUNESCO::QUÍMICA::Química orgánica
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Metronidazola kvantitatīvā noteikšana farmaceitiskā preparātā

2016

Metronidazola kvantitatīvā noteikšana farmaceitiskā preparātā. Lazdāne L., zinātniskais vadītājs Dr. Ķīm. Nakurte, I. Maģistra darbs, 54 lappuses, 23 attēli, 20 tabulas, 45 literatūras avoti, 2 pielikumi. Latviešu valodā. Veikts literatūras apkopojums par farmaceitiski aktīvo vielu metronidazolu un tā farmakoloģiskajām īpašībām. Noskaidrotas metronidazola ekstrakcijas un analītiskās noteikšanas metodes. Balstoties uz ICH vadlīnijām veikta metronidazola kvantitatīvās noteikšanas metodes Metronidazola 7,5 mg/g gelā validācija. Validācijas ietvaros noteikta hromatogrāfiskās metodes linearitāte, noteikšanas robežas, pareizība un precizitāte, atkārtojamība, robustums. Pārbaudīta metronidazola st…

AEŠHMETRONIDAZOLSDEGRADĀCIJAGELSPIEMAISĪJUMIĶīmija
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Tetrazīna ciklu saturoši proteīnu linkeri biokonjugācijā

2022

Tetrazīna ciklu saturoši proteīnu linkeri biokonjugācijā. Strazdiņa R., zinātniskais vadītājs doc. Kļimenkovs I., bakalaura darbs, 39 lappuses, 49 attēli, 33 literatūras avoti, 3 pielikumi. Latviešu valodā. PROTEĪNU LINKERI, 1,2,3-TRIAZOLS, TETRAZĪNS, ALDEHĪDGRUPA Izstrādāta 7 soļu sintēze proteīnu linkerim, kas satur 1,2,3-triazola ciklu, kā arī tetrazīna ciklu un aldehīdgrupu piesaistīšanai mērķa molekulām.

ALDEHĪDGRUPAPROTEĪNU LINKERI123-TRIAZOLSTETRAZĪNSĶīmija
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Central functional response to the novel peptide cannabinoid, hemopressin.

2013

Hemopressin is the first peptide ligand to be described for the CB₁ cannabinoid receptor. Hemopressin acts as an inverse agonist in vivo and can cross the blood-brain barrier to both inhibit appetite and induce antinociception. Despite being highly effective, synthetic CB₁ inverse agonists are limited therapeutically due to unwanted, over dampening of central reward pathways. However, hemopressin appears to have its effect on appetite by affecting satiety rather than reward, suggesting an alternative mode of action which might avoid adverse side effects. Here, to resolve the neuronal circuitry mediating hemopressin's actions, we have combined blood-oxygen-level-dependent, pharmacological-ch…

AM251MaleCannabinoid receptorHypothalamus MiddleNerve Tissue ProteinsNucleus accumbensSatiety ResponseRats Sprague-DawleyCellular and Molecular Neurosciencechemistry.chemical_compoundHemoglobinsMiceRandom AllocationPiperidinesReceptor Cannabinoid CB1Appetite DepressantsmedicineInverse agonistAnimalsPeriaqueductal GrayPharmacologyMice KnockoutNeuronsBehavior AnimalCannabinoidsHemopressinPeptide FragmentsRatsVentral tegmental areamedicine.anatomical_structurechemistryPyrazolesRaphe NucleiBrain stimulation rewardRaphe nucleiPsychologyNeuroscienceInjections Intraperitonealmedicine.drugNeuropharmacology
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Cannabinoid type 1 receptor modulates intestinal propulsion by an attenuation of intestinal motor responses within the myenteric part of the peristal…

2007

Cannabinoid-1 (CB1) receptor activation affects gastrointestinal propulsion in vivo. It was our aim to further characterize the involved myenteric mechanisms in vivo and in vitro. In CB1(-/-) mice and wild-type littermates we performed in vivo transit experiments by charcoal feeding and in vitro electrophysiological recordings in mouse small intestinal smooth muscle. Ascending neuronal contraction (ANC) following electrical field stimulation was studied in rat ileum in a partitioned organ bath separating the aboral stimulation site from the oral recording site. The knockout animals displayed an accelerated upper gastrointestinal transit compared to control animals. The CB1 receptor antagoni…

AM251Malemedicine.medical_specialtyCannabinoid receptorPhysiologyPolyunsaturated Alkamidesmedicine.medical_treatmentNeuromuscular JunctionMotilityStimulationArachidonic AcidsBiologyNeuromuscular junctionMembrane PotentialsMiceOrgan Culture TechniquesPiperidinesReceptor Cannabinoid CB1Internal medicineCannabinoid Receptor ModulatorsReflexmedicineAnimalsRNA MessengerIntestinal MucosaRats WistarReceptorMice KnockoutMyoelectric Complex MigratingEndocrine and Autonomic SystemsReverse Transcriptase Polymerase Chain ReactionGastroenterologyMuscle SmoothEndocannabinoid systemElectric StimulationRatsIntestinesEndocrinologymedicine.anatomical_structurePyrazolesPeristalsisCannabinoidmedicine.drugEndocannabinoidsNeurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
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Activation of AMPK by medicinal plants and natural products: Its role in type 2 diabetes mellitus

2019

Type-2 Diabetes (T2D) is a metabolic disease characterized by permanent hyperglycemia, whose development can be prevented or delayed by using therapeutic agents and implementing lifestyle changes. Some therapeutic alternatives include regulation of glycemia through modulation of different mediators and enzymes, such as AMP-activated protein kinase (AMPK), a highly relevant cellular energy sensor for metabolic homeostasis regulation, with particular relevance in the modulation of liver and muscle insulin sensitivity. This makes it a potential therapeutic target for antidiabetic drugs. In fact, some of them are standard drugs used for treatment of T2D, such as biguanides and thiazoli-dindione…

AMPKCIENCIAS MÉDICAS Y DE LA SALUDBiguanidesAMP-Activated Protein KinasesPharmacologyResveratrolCarbohydrate metabolismNATURAL PRODUCTS03 medical and health scienceschemistry.chemical_compound0302 clinical medicineBerberineDiabetes mellitusDrug DiscoveryHumansHypoglycemic AgentsMedicineTYPE 2 DIABETES MELLITUSProtein kinase A030304 developmental biologyPharmacologychemistry.chemical_classificationBiological Products0303 health sciencesPlants Medicinalbusiness.industryType 2 Diabetes MellitusAMPKGeneral MedicineBioquímica y Biología Molecularmedicine.diseaseANTIDIABETIC DRUGSMedicina BásicaGlucoseEnzymeDiabetes Mellitus Type 2chemistry030220 oncology & carcinogenesisThiazolidinedionesbusinessMEDICINAL PLANTS
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Gāzu hromatogrāfijas tvaika fāzes metodes validācija atlikušo šķīdinātāju noteikšanai

2022

Gāzu hromatogrāfijas tvaika fāzes metodes validācija atlikušo šķīdinātāju noteikšanai Linezolīda aktīvajā vielā. Fjodorova V., darba vadītāji Dr. chem., Rudoviča V., Mg. Chem. Antonoviča S. Bakalaura darbs, 77 lappuses, 29 tabulas, 7 attēli, 23 literatūras avoti, 50 pielikumi. Latviešu valodā. Darbā ir apkopota literatūra par farmaceitiski aktīvo vielu Linezolīds, šīs vielas sintēzes stadijām un atlikušajiem šķīdinātājiem esošajā produktā. Apkopota un izvērtēta informācija arī par gāzu hromatogrāfijas metodi un analīzes metodes validāciju. Pētnieciskajā darbā ir noskaidroti piemērotākie gāzu hromatogrāfijas analīzes apstākļi visu atlikušo šķīdinātāju (Metanola, Acetonitrila, Izopropanola, T…

ATLIKUŠIE ŠĶĪDINĀTĀJI AKTĪVĀ FARMACEITISKĀ VIELĀLINEZOLĪDSTVAIKA FĀZES GĀZU HROMATOGRĀFIJAGĀZU HROMATOGRĀFIJAANALĪZES METODES IZSTRĀDEĶīmija
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Binding mode analysis of ABCA7 for the prediction of novel Alzheimer's disease therapeutics

2021

Graphical abstract

ATP Adenosine-triphosphateNBD nucleotide binding domainGSH reduced glutathionePolypharmacologyAlzheimer’s disease (AD)ATP-binding cassette transporterHTS high-throughput screeningBiochemistryABCA7Structural BiologyPLIF protein ligand interactionMSD membrane spanning domainPDB protein data bankTM transmembrane helixABC ATP-binding cassetteMultitarget modulation (PANABC)RMSD root mean square distanceABC transporter (ABCA1 ABCA4 ABCA7)Computer Science ApplicationsMOE Molecular Operating EnvironmentPharmacophoreSNP single-nucleotide polymorphismBiotechnologyResearch ArticleBBB blood-brain barrierBiophysicsDrug designComputational biologyBiologyAD Alzheimer’s diseasePET positron emission tomographyIC intracellular helixAPP amyloid precursor proteincryo-EM cryogenic-electron microscopyGeneticsHomology modelingBinding siteRational drug design and developmentComputingMethodologies_COMPUTERGRAPHICSNBD-cholesterol 7-nitro-2-13-benzoxadiazol-4-yl-cholesterolTransporterPSO particle swarm optimizationPET tracer (PETABC)ECD extracellular domainR-domain/region regulatory domain/regionABCA1biology.proteinEH extracellular helixTP248.13-248.65BODIPY-cholesterol 44-difluoro-4-bora-3a4a-diaza-s-indacene-cholesterolComputational and Structural Biotechnology Journal
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