Search results for "ZOL"

Translational readthrough of ciliopathy genes BBS2 and ALMS1 restores protein, ciliogenesis and function in patient fibroblasts

2021

Abstract Background Ciliary dysfunction underlies a range of genetic disorders collectively termed ciliopathies, for which there are no treatments available. Bardet-Biedl syndrome (BBS) is characterised by multisystemic involvement, including rod-cone dystrophy and renal abnormalities. Together with Alstrom syndrome (AS), they are known as the ‘obesity ciliopathies’ due to their common phenotype. Nonsense mutations are responsible for approximately 11% and 40% of BBS and AS cases, respectively. Translational readthrough inducing drugs (TRIDs) can restore full-length protein bypassing in-frame premature termination codons, and are a potential therapeutic approach for nonsense-mediated ciliop…

Makrocikli kā vienkāršoti Diazonamīda A analogi

2022

Makrocikli kā vienkāršoti Diazonamīda A analogi. Bariševa J., zinātniskā vadītāja MSc. chem. Vitkovska V. Bakalaura darbs. 63 lpp., 54 attēli, 2 tabulas, 34 literatūras avoti, 1 pielikums. Latviešu valodā. Bakalaura darba ietvaros ir veikta trīs vienkāršotu makrociklisku Diazonamīda A struktūranalogu sintēze, optimizējot makrociklizācijas reakcijas apstākļus. Izmantojot datormodelēšanas aprēķinus katram no makrocikliem ir noteiktas aktivācijas enerģijas vērtības ciklizācijas reakcijai.

Memuāra tēla veidošanas stratēģijas A. Solžeņicina darbā "Badījās telēns ar ozolu".

2022

Darbs ir veltīts pētījumam par memuāra tēla veidošanas stratēģijām Aleksandra Solžeņicina darbā "Badījās telēns ar ozolu". Pētījuma mērķis ir to faktoru un autora paņēmienu analīze, kas ļautu parādīt memuāra tēla veidošanos darbā "Badījās telēns ar ozolu". Darbs sastāv no trijām daļām. Pirmajā daļā tiks aplūkots memuāra literatūras jēdziens, tās pamata īpašības, tās žanri un autora tēls memuāra tekstā. Darba otrajā daļā tiks pētīts A. Solžeņicina darbs "Badījās telēns ar ozolu" un izskatītas tam raksturīgākas īpašības. Trešajā daļā tiks paradīti memuāra tēla veidošana mehānismi un principi, balstoties uz autoru A. Tvardovska un V. Lakšina piemēriem. Šīs darbs varētu būt interesants kā filol…

Effect of linker distribution in the photocatalytic activity of multivariate mesoporous crystals

2021

The use of Metal-Organic Frameworks as crystalline matrices for the synthesis of multiple component or multivariate solids by the combination of different linkers into a single material has emerged as a versatile route to tailor the properties of single-component phases or even access new functions. This approach is particularly relevant for Zr6-MOFs due to the synthetic flexibility of this inorganic node. However, the majority of materials are isolated as polycrystalline solids, which are not ideal to decipher the spatial arrangement of parent and exchanged linkers for the formation of homogeneous structures or heterogeneous domains across the solid. Here we use high-throughput methodologi…

Unkarilaisen talonpoikaismusiikin vaikutteet Béla Bartókin toisessa viulukonsertossa

2000

Non-Innocent Base Properties of 3- and 4-Pyridyl-dithia- and Diselenadiazolyl Radicals : The Effect of N-Methylation

2018

International audience; Condensation of persilylated nicotinimideamide and isonicotinimideamide with sulfur monochloride affords double salts of the 3-, 4-pyridyl-substituted 1,2,3,5-dithiadiazolylium DTDA cations of the general formula [3-, 4-pyDTDA][Cl][HCl] in which the pyridyl nitrogen serves as a noninnocent base. Reduction of these salts with triphenylantimony followed by deprotonation of the intermediate-protonated radical affords the free base radicals [3-, 4-pyDTDA], the crystal structures of which, along with those of their diselenadiazolyl analogues [3-, 4-pyDSDA], have been characterized by powder or single-crystal X-ray diffraction. The crystal structures consist of “pancake” π…

Experimental observations of upstream overdeepening

2005

The issue of morphodynamic influence in meandering streams is investigated through a series of laboratory experiments on curved and straight flumes. Both qualitative and quantitative observations confirm the suitability of the recent theoretical developments (Zolezzi & Seminara 2001) that indicate the occurrence of two distinct regimes of morphodynamic influence, depending on the value of the width ratio of the channel β. The threshold value βR separating the upstream from the downstream influence regimes coincides with the resonant value discovered by Blondeaux & Seminara (1985). Indeed it is observed that upstream influence may occur only in relatively wide channels, while narrower stream…

Influence of side chain characteristics on the aggregation-induced emission (AIE) properties of tetrasubstituted tetraphenylethylene (TPE)

2017

[EN] Five new tetraphenylethylene (TPE) derivatives were synthesised and their aggregation-induced emission (AIE) was evaluated in mixtures of THF/water and MeOH/water. The influence of regiochemistry and length of the chains in the substituents on emissive properties was studied.

Synthesis and characterisation of N-glycosyl amines from the reaction between 4,6-O-benzylidene-D-glucopyranose and substituted aromatic amines and a…

2001

Twelve N-glycosyl amines were synthesised using 4,6-O–benzylidene-D-glucopyranose and different substituted aromatic amines, including some diamines that resulted in bis-glycosyl amines. Another set of six N–glycosyl amines was synthesised using different hexoses and pentoses and 2–(o–aminophenyl)benzimidazole. All compounds were isolated as solid products and purified, their elemental compositions were established, and these were characterised by NMR (1H and 13C), UV–Vis, and FTIR spectroscopy, by FAB mass spectrometry (molecular-ion peaks gave molecular weights), and by their optical rotations. While the protected saccharide, 4,6-O-benzylidene-D-glucopyranose, exists as a mixture of β and…

Discovery of benzimidazole-based Leishmania mexicana cysteine protease CPB2.8ΔCTE inhibitors as potential therapeutics for leishmaniasis

2018

Abstract: Chemotherapy is currently the only effective approach to treat all forms of leishmaniasis. However, its effectiveness is severely limited due to high toxicity, long treatment length, drug resistance, or inadequate mode of administration. As a consequence, there is a need to identify new molecular scaffolds and targets as potential therapeutics for the treatment of this disease. We report a small series of 1,2‐substituted‐1H‐benzo[d]imidazole derivatives (9ad) showing affinity in the submicromolar range (Ki = 0.150.69 μM) toward Leishmania mexicanaCPB2.8ΔCTE, one of the more promising targets for antileishmanial drug design. The compounds confirmed activity in vitro against intrace…