Search results for "ZOL"
showing 10 items of 4792 documents
Diverse compounds mimic Alzheimer disease–causing mutations by augmenting Aβ42 production
2004
Increased Abeta42 production has been linked to the development of Alzheimer disease. We now identify a number of compounds that raise Abeta42. Among the more potent Abeta42-raising agents identified are fenofibrate, an antilipidemic agent, and celecoxib, a COX-2-selective NSAID. Many COX-2-selective NSAIDs tested raised Abeta42, including multiple COX-2-selective derivatives of two Abeta42-lowering NSAIDs. Compounds devoid of COX activity and the endogenous isoprenoids FPP and GGPP also raised Abeta42. These compounds seem to target the gamma-secretase complex, increasing gamma-secretase-catalyzed production of Abeta42 in vitro. Short-term in vivo studies show that two Abeta42-raising comp…
Imidazolium-Functionalized Carbon Nanohorns for the Conversion of Carbon Dioxide
2016
Six new hybrid materials composed of carbon nanohorns (CNHs) and highly cross-linked imidazolium salts were easily synthesized using a one-step procedure based on the radical oligomerization of bis-vinylimidazolium salts (bVImiX) in the presence of pristine CNHs. The hybrid materials were characterized and employed as the sole catalysts for the conversion of carbon dioxide into cyclic carbonate by reaction with epoxides. The solids displayed excellent turnover number and productivity. Moreover, four catalysts were investigated in recycling experiments. Two catalysts containing an octyl linker between the imidazolium units and a bromide or an iodide anion showed no loss in activity after thr…
Distribution of chlorpromazine in a simplified blood influenced by various drugs
1973
The binding of chlorpromazine to erythrocytes and to albumin as influenced by other drugs was studied in a simplified blood (31.5±0.3% bovine erythrocytes, 4 g-% bovine serum albumin in 0.02 M phosphate buffer solution containing 0.15 M NaCl). the total concentration of chlorpromazine in the simplified blood was 10−4 M, the concentration of the displacing drugs was 10−3 M. After an incubation period of 3 h at 22° C the chlorpromazine concentration was determined in the albumin solution after centrifugation of the blood at 3000×g and in the aqueous phase after ultracentrifugation at 150000×g. Under control conditions 68.1±0.9% of chlorpromazine was bound to the erythrocytes, 28.5±0.9% was bo…
Synthèse et réactivité chimiques et électrochimiques de dérivés d'imidazoliums : vers des procédés éco-responsables
2015
This work deals with the use of electrochemistry as a tool for alternative synthesis of new azolium-based molecules.A new electrosynthesis method was developed for the synthesis of imidazolium carboxylates (masked carbenes) leading to a wide library of compounds. This approach was compared to already reported chemical syntheses. In the current context of sustainable development, bio based products have been synthesized and optimization of the process was achieved in order to reduce waste and energy consumption.The key role of the hydrogenoxalate anion was demonstrated in the synthesis of ionic liquids and/or imidazolium salts. Some of them were employed as recyclable catalysts for Fischer e…
Triazolopyridines. Part 30. Hydrogen transfer reactions; pyridylcarbene formation
2013
The transfer hydrogenation reaction of (1,2,3)triaz olo(1,5-a)pyridines with Pd/C/Zn or Pd(OH) 2/C/Zn in water, ethanol or water/ethanol mixture ha s been explored. 4,5,6,7-Tetrahydro- triazolopyridines were obtained in good to medium yields. In addition, under the same conditions 2-substituted pyridines were also formed as a resul t of intermediate pyridylcarbene formation, by triazole ring opening and loss of nitrogen.
CCDC 766325: Experimental Crystal Structure Determination
2010
Related Article: L.Kiss, E.Forro, R.Sillanpaa, F.Fulop|2010|Tetrahedron|66|3599|doi:10.1016/j.tet.2010.03.030
CCDC 707421: Experimental Crystal Structure Determination
2009
Related Article: L.Kiss, M.Nonn, E.Forro, R.Sillanpaa, F.Fulop|2009|Tetrahedron Lett.|50|2605|doi:10.1016/j.tetlet.2009.03.119
Titanium and vanadium catalysts with oxazoline ligands for ethylene-norbornene (co)polymerization
2018
A series of catalysts, (Py-ox)TiCl4, (Py-box)TiCl4, (Py-ox)VCl3, (Py-box)VCl3, SIL/(Py-ox)VCl3, SIL/(Py-box)VCl3, with 2-(1,3-oxazolin-2-yl)pyridine (Py-ox) and 2,6-bis(1,3-oxazolin-2-yl)pyridine (Py-box) ligands, silica support modified by 1-[3-(triethoxysilyl)propyl]pyridinium ethylchloroaluminate ionic liquid (SIL), activated by AlEt2Cl, AlEtCl2, and methylaluminoxane (MMAO) were studied in ethylene polymerization and ethylene-norbornene copolymerization. Single-crystal X-ray diffraction is given for both Py-ox and Py-box. The complexation was confirmed by NMR and ESI-MS methods. All complexes were found to be active in ethylene polymerization with better performance of the vanadium cata…
Reactive melt blending of functionalized-MW/CNTs with polyolefin
2012
Adding nanotube adding into a polymeric matrix leads to the formulation of nanocomposites with enhanced macroscopical performances, and, moreover, the use of functionalized MW-CNTs leads to the nanocomposite formulation with even better properties. Furthermore, the reactive melt blending can be considered as a powerful processing method, i.e. reasonably simple and ecologically friendly, in order to formulate polymer based nanocomposite with good performance. In this work, the reactive melt blending between an ethylene-acrylic acid co-polymer, bis-oxazoline and functionalized MW-CNTs was performed and the rheological properties of the formulated systems were investigated.
Understanding the domino reaction between 3-chloroindoles and methyl coumalate yielding carbazoles. A DFT study.
2014
The molecular mechanism of the reaction between N-methyl-3-chloroindole and methyl coumalate yielding carbazole has been studied using DFT methods at the MPWB1K/6-311G(d,p) level in toluene. This reaction is a domino process that comprises three consecutive reactions: (i) a polar Diels-Alder (P-DA) reaction between indole and methyl coumalate yielding two stereoisomeric [2 + 4] cycloadducts (CAs); (ii) the elimination of HCl from these CAs affording two stereoisomeric intermediates; and (iii) the extrusion of CO2 in these intermediates, finally yielding the carbazole. This P-DA reaction proceeds in a completely regioselective and slightly exo selective fashion. In spite of the highly polar …