Search results for "Zole"

showing 10 items of 2482 documents

CCDC 1935934: Experimental Crystal Structure Determination

2020

Related Article: Rakesh Puttreddy, J. Mikko Rautiainen, Toni Mäkelä, Kari Rissanen|2019|Angew.Chem.,Int.Ed.|58|18610|doi:10.1002/anie.201909759

1H-12-benzothiazole-113(2H)-trione 26-dimethyl-1-pyridine N-oxideSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1421617: Experimental Crystal Structure Determination

2016

Related Article: Jakob Wudarczyk, George Papamokos, Vasilis Margaritis, Dieter Schollmeyer, Felix Hinkel, Martin Baumgarten, George Floudas, Klaus Müllen|2016|Angew.Chem.,Int.Ed.|55|3220|doi:10.1002/anie.201508249

22-Dimethyl-23-dihydro-1H-benzimidazole-4567-tetracarbonitrile tetrahydrofuran solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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Synthesis and anti-HIV activity of 2,3-diaryl-1,3-thiazolidin-4-(thi)one derivatives.

2002

Several 2,3-diaryl-1,3-thiazolidine-4-thione derivatives and 2,3-diaryl-1,3-thiazolidin-4-ones bearing a methyl group at C-5 position have been synthesized and tested as anti-HIV agents. The results of the in vitro tests showed that some of them proved to be effective inhibitors of HIV-1 replication.

23-Diaryl-13-thiazolidine-4-thioneAnti-HIV activity23-Diaryl-13-thiazolidin-4-oneStereochemistryAnti-HIV AgentsCell SurvivalPharmaceutical ScienceVirus ReplicationChemical synthesischemistry.chemical_compoundInhibitory Concentration 50Structure-Activity RelationshipThiadiazolesDrug DiscoveryThiadiazolesmedicineTumor Cells CulturedStructure–activity relationshipHumansAnti hiv activityReverse-transcriptase inhibitorGeneral MedicineSettore CHIM/08 - Chimica FarmaceuticaIn vitrochemistryNNRTIsLactamHIV-1EpimerMethyl groupmedicine.drugFarmaco (Societa chimica italiana : 1989)
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CCDC 827086: Experimental Crystal Structure Determination

2011

Related Article: A.Kudelko, W.Zielinski, K.Ejsmont|2011|Tetrahedron|67|7838|doi:10.1016/j.tet.2011.07.047

2-(1-Amino-11-diphenylmethyl)-5-phenyl-134-oxadiazoleSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 780779: Experimental Crystal Structure Determination

2013

Related Article: F.Emmerling, I.Orgzall, B.Dietzel, B.Schulz, J.Larrucea|2012|J.Mol.Struct.|1030|209|doi:10.1016/j.molstruc.2012.04.040

2-(Biphenyl-4-yl)-5-(4-t-butylphenyl)-134-oxadiazoleSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 780778: Experimental Crystal Structure Determination

2013

Related Article: F.Emmerling, I.Orgzall, B.Dietzel, B.Schulz, J.Larrucea|2012|J.Mol.Struct.|1030|209|doi:10.1016/j.molstruc.2012.04.040

2-(Biphenyl-4-yl)-5-phenyl-134-oxadiazoleSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 653860: Experimental Crystal Structure Determination

2008

Related Article: A.P.Piccionello, A.Pace, S.Buscemi, N.Vivona, M.Pani|2008|Tetrahedron|64|4004|doi:10.1016/j.tet.2008.02.047

2-amino-4-trifluoromethyl-5-benzoyl-1H-imidazoleSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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COVID-19 in Philadelphia-negative myeloproliferative disorders: a GIMEMA survey

2020

2019-20 coronavirus outbreakPediatricsmedicine.medical_specialtyCancer ResearchCoronavirus disease 2019 (COVID-19)EpidemiologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Pneumonia ViralPhiladelphia chromosomeSeverity of Illness IndexMyeloproliferative diseaseBetacoronavirusMyeloproliferative DisordersLeukemia Myelogenous Chronic BCR-ABL PositiveCorrespondenceNitrilesmedicineHumansPhiladelphia ChromosomeBetacoronavirus COVID-19 Coronavirus Infections Cross-Sectional Studies Disease Progression Humans Italy Leukemia Myelogenous Chronic BCR-ABL Positive Philadelphia Chromosome Pneumonia Viral Pyrazoles SARS-CoV-2 Severity of Illness Index Survival Analysis PandemicsPandemicsPhiladelphia negativebusiness.industrySARS-CoV-2Disease progressionCOVID-19Hematologymedicine.diseaseSurvival AnalysisCross-Sectional StudiesPyrimidinesItalyOncologyDisease ProgressionPyrazolesbusinessCoronavirus InfectionsCoronavirus InfectionsLeukemia
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SYNTHESIS AND ANTITUMOR ACTIVITY OF 2,5-BIS(3'-INDOLYL)-FURANS AND 3,5-BIS(3'-INDOLIY)-ISOXAZOLES, NORTOPSENTIN ANALOGUES

2010

Abstract A series of novel 2,5-bis(3′-indolyl)furans and 3,5-bis(3′-indolyl)isoxazoles were synthesized as antitumor agents. The antiproliferative activity was evaluated in vitro toward diverse human tumor cell lines. Initially 5 isoxazoles and 3 furan derivatives were tested against a panel of 10 human tumor cell lines and the most active derivatives 3c and 4a were selected to be evaluated in an extended panel of 29 cell lines. By exhibiting mean IC50 values of 17.4 μg/mL (3a) and 20.5 μg/mL (4c), in particular 4c showed a high level of tumor selectivity toward the 29 cell lines.

35-BIS(3'-INDOLIY)-ISOXAZOLESIndolesStereochemistry3Clinical Biochemistry2Pharmaceutical ScienceAntineoplastic AgentsBiochemistryChemical synthesis25-BIS(3'-INDOLYL)-FURANSchemistry.chemical_compound2; 5-BIS(3'-INDOLYL)-FURANS; 3; 5-BIS(3'-INDOLIY)-ISOXAZOLES; NORTOPSENTIN; ANTITUMOR ACTIVITYFuranCell Line TumorNeoplasmsDrug DiscoveryHumans5-BIS(3'-INDOLIY)-ISOXAZOLESCytotoxicityFurans5-BIS(3'-INDOLYL)-FURANSMolecular BiologyAntitumor activityAlkaloidOrganic ChemistryBiological activityNORTOPSENTINIsoxazolesSettore CHIM/08 - Chimica FarmaceuticaIn vitroANTITUMOR ACTIVITYchemistryCell cultureMolecular MedicineDrug Screening Assays Antitumor
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CCDC 684501: Experimental Crystal Structure Determination

2008

Related Article: M.Holm, D.Schollmeyer, S.Laufer|2008|Acta Crystallogr.,Sect.E:Struct.Rep.Online|64|o700|doi:10.1107/S1600536808003917

3-(2-Fluorophenyl)-6-(phenoxymethyl)-124-triazolo(34-b)(134)thiadiazoleSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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