Search results for "Zopiclone"

showing 3 items of 3 documents

Acute, subchronic and discontinuation effects of zopiclone on sleep EEG and nocturnal melatonin secretion

1996

Zopiclone is a new short half-life cyclopyrrolone hypnotic agent acting at the GABA-benzodiazepine receptor complex. In order to characterize its pharmacological profile, the effects of 7.5 mg zopiclone on nocturnal melatonin secretion were investigated under polysomnographic control in 11 healthy subjects following acute and subchronic administration as well as after abrupt discontinuation of the drug. No effect of zopiclone on the melatonin plasma levels could be observed. Regarding both total melatonin production and the temporal pattern of melatonin secretion during the night, there was no difference between placebo baseline condition, acute and subchronic administration, and discontinu…

AdultDrugReceptor complexmedicine.medical_specialtyTime Factorsmedicine.drug_classmedia_common.quotation_subjectPharmacologyPlaceboPiperazinesHypnoticMelatoninInternal medicinemedicineHumansHypnotics and SedativesPharmacology (medical)ChildBiological PsychiatryMelatoninmedia_commonPharmacologyZopicloneElectroencephalographyDiscontinuationPsychiatry and Mental healthEndocrinologyNeurologyPharmacodynamicsNeurology (clinical)SleepPsychologyAzabicyclo Compoundsmedicine.drugEuropean Neuropsychopharmacology
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Functional properties of the brain during sleep under subchronic zopiclone administration in man.

1994

Zopiclone, a non-benzodiazepine, has been shown to be efficient in the treatment of transient, short-term or chronic sleep disorders. Apart from its hypnotic effects zopiclone has anxiolytic, anticonvulsant and myorelaxant properties and is therefore hardly distinguishable from benzodiazepines. Dependence liability and discontinuation effects have been reported to be less pronounced. Therefore zopiclone seems to be a hypnotic drug which may cause fewer side effects than conventional benzodiazepines. From the electrophysiological point of view one requires from a hypnotic drug the induction of a physiological sleep pattern as well as no alterations of information processing by the brain. The…

AdultMalemedicine.drug_classmedicine.medical_treatmentPolysomnographyStimulationPolysomnographyAnxiolyticPiperazinesMental ProcessesmedicineHumansHypnotics and SedativesPharmacology (medical)Biological PsychiatryPharmacologyZopicloneSleep Stagesmedicine.diagnostic_testBrainElectroencephalographySleep in non-human animalsPsychiatry and Mental healthElectrophysiologyAnticonvulsantNeurologyAnesthesiaEvoked Potentials AuditoryEvoked Potentials VisualNeurology (clinical)Sleep StagesPsychologySleepNeuroscienceAzabicyclo Compoundsmedicine.drugEuropean neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
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Zaleplon displays a selectivity to recombinant GABAA receptors different from zolipdem, zopiclone and benzodiazepines

1999

A chemically heterogeneous group of compounds acts at the benzodiazepine (BZ) recognition site of the γ-aminobutyric acid type A (GABAA) receptor complex. Whereas most 1,4-BZs recognize all GABAA/BZ receptors with similar affinity, other compounds differentiate between the large number of native GABAA receptors which assemble from the more than 14 known subunits. Here we describe the in vitro binding properties of the BZs lorazepam and Ro 15-4513 plus the three hypnotics zaleplon, zolpidem and zopiclone to eight receptors subtypes. Lorazepam fits well into the general shceme for other 1,4-BZs with respect to its receptor subtype selectivity in spite of its clinically different use. Zaleplon…

ZopicloneZolpidemReceptor complexBenzodiazepineGABAA receptorChemistrymedicine.drug_classStereochemistryGeneral NeurosciencePharmacologyHypnoticZaleplonmedicineReceptormedicine.drugNeuroscience Research Communications
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