Search results for "acetamide"
showing 10 items of 142 documents
Investigation into Stereoselective Pharmacological Activity of Phenotropil
2011
Phenotropil (N-carbamoylmethyl-4-aryl-2-pyrrolidone (2-(2-oxo-4-phenyl-pyrrolidin-1-yl) acetamide; carphedon)) is clinically used in its racemic form as a nootropic drug that improves physical condition and cognition. The aim of this study was to compare the stereoselective pharmacological activity of R- and S-enantiomers of phenotropil in different behavioural tests. Racemic phenotropil and its enantiomers were tested for locomotor, antidepressant and memory-improving activity and influence on the central nervous system (CNS) using general pharmacological tests in mice. After a single administration, the amount of compound in brain tissue extracts was determined using an ultra performance …
FT-IR investigation of the acetamide state in AOT reversed micelles
2003
The state of acetamide nanoparticles encapsulated in the hydrophilic core of sodium bis(2-ethylhexyl) sulfosuccinate (AOT) reversed micelles and dispersed in CCl4 has been investigated by Fourier transform infrared spectroscopy. The analysis of the vibrational spectra reveals even at the higher acetamide to AOT molar ratio some changes of the typical H-bonded structure of solid acetamide ascribable to their small size, confinement effects, and acetamide-AOT head group interactions. The stretching modes of acetamide CO and AOT sulfonate groups indicate unambiguously specific acetamide-AOT head group interactions.
Immunoproteasome and Non-Covalent Inhibition: Exploration by Advanced Molecular Dynamics and Docking Methods
2021
The selective inhibition of immunoproteasome is a valuable strategy to treat autoimmune, inflammatory diseases, and hematologic malignancies. Recently, a new series of amide derivatives as non-covalent inhibitors of the β1i subunit with Ki values in the low/submicromolar ranges have been identified. Here, we investigated the binding mechanism of the most potent and selective inhibitor, N-benzyl-2-(2-oxopyridin-1(2H)-yl)propanamide (1), to elucidate the steps from the ligand entrance into the binding pocket to the ligand-induced conformational changes. We carried out a total of 400 ns of MD-binding analyses, followed by 200 ns of plain MD. The trajectories clustering allowed identifying thre…
Structural insight into the reaction mechanism of Pd-catalyzed nitrile hydration: Trapping the [Pd(H2O)4]2+ cation through a supramolecular complex
2016
Abstract Four new bis(oxamato)palladate(II) complexes of formula (n-Bu4N)2[Pd(2,4,6-Me3pma)2]·2CH3CN (1), (n-Bu4N)2[Pd(2,4,6-Me3pma)2]·2CH3CONH2 (2) and (n-Bu4N)4[Pd(H2O)4][Pd(4-Xpma)2]3·2CH3CONH2 with X = Br (3) and Cl (4) (2,4,6-Me3pma = N-2,4,6-trimethylphenyloxamate, 4-Brpma = N-4-bromophenyloxamate, N-4-chlorophenyloxamate and n-Bu4N+ = tetra-n-butylammonium) have been obtained and characterized by single crystal X-ray diffraction. All of them contain bis(oxamato)palladate(II) anions and bulky n-Bu4N+ cations, but compounds 3 and 4 have also the out of the ordinary [Pd(H2O)4]2+ inorganic cation. Acetonitrile and appealing acetamide are present as lattice molecules in compounds (1) and …
Modulation of mucin 2 and mucin 3 in colitis induced by iodoacetamide and enteropathogenic bacteria in rats
2016
The iinate and acquired immune systems are both implicarted in the etiology of Inflammatory Bowel Disease (IBD) in addition to the genetic predisposition, the environmental factors and the intestinal flora covering the mucosa. A defect in the mucous covering will lead to an invasion of pathogens and stimulation of the immuune response with aberrations of mucin 2, the major mucin of the mucous layer. Aim: this study aims to assess the modulation of colonic MUC 2 and MUC 3 in a arat model of IBD induced by a combination of iodoacetamide and enteropatogenic E. Coli. Methods: 78 sprague-Dawley female rats were divided into 4 groups. Each group was subjeceted, on a basis, to a rectal injection o…
CCDC 1039550: Experimental Crystal Structure Determination
2015
Related Article: N. Kodiah Beyeh, Altti Ala-Korpi, Fangfang Pan, Hyun Hwa Jo, Eric V. Anslyn, Kari Rissanen|2015|Chem.-Eur.J.|21|9556|doi:10.1002/chem.201406504
CCDC 957915: Experimental Crystal Structure Determination
2013
Related Article: Borys Ośmiałowski, Erkki Kolehmainen, Krzysztof Ejsmont, Satu Ikonen, Arto Valkonen, Kari Rissanen, Nonappa|2013|J.Mol.Struct.|1054|157|doi:10.1016/j.molstruc.2013.09.047
CCDC 1006725: Experimental Crystal Structure Determination
2014
Related Article: Hanna Jędrzejewska, Michał Wierzbicki, Piotr Cmoch, Kari Rissanen, Agnieszka Szumna|2014|Angew.Chem.,Int.Ed.|53|13760|doi:10.1002/anie.201407802
CCDC 1945312: Experimental Crystal Structure Determination
2020
Related Article: Agris Be̅rziņš, Artis Kons, Kristaps Saršu̅ns, Sergey Belyakov, Andris Actiņš|2020|Cryst.Growth Des.|20|5767|doi:10.1021/acs.cgd.0c00331
CCDC 1523462: Experimental Crystal Structure Determination
2017
Related Article: Toms Rekis, Agris Be̅rziņš, Lia̅na Orola Tamás Holczbauer, Andris Actinš, Andreas Seidel-Morgenstern, Heike Lorenz|2017|Cryst.Growth Des.|17|1411|doi:10.1021/acs.cgd.6b01867