Search results for "acide"
showing 10 items of 100 documents
Effects of modulation of body fat in production of adiponectin in mice : consequences on hepatic metabolism of lipids
2010
Adiponectin (ApN), a 30-kDa adipokine abundantly produced by adipose tissue has been described for the first time in 1995. Early findings demonstrating serum adiponectin levels are inversely correlated with obesity initiated intense investigation of the relationship between adiponectin and all symptoms of the metabolic syndrome. Of these studies, strong evidence suggests that a weight loss induced by medication or hypocaloric diet led to increased circulating ApN levels and improvement of biochemical parameters. Thus, high levels of ApN have been correlated with an improvement of insulin sensitivity and lipid parameters reducing cardiovascular risk. However mechanisms involved in the improv…
Uso de medicamentos associados ao risco de quedas em idosos não institucionalizados
2018
RESUMEN Objetivo: Determinar qué número de medicamentos consumidos diariamente es influyente en el riesgo de caídas en ancianos no institucionalizados y con historial de caídas en el último año. Método: Estudio descriptivo mediante muestreo aleatorio con la utilización de los siguientes instrumentos de medida: cuestionario de la OMS para el estudio de caídas en el anciano, escala de marcha y escala depresión geriátrica y escala de marcha y equilibrio. El análisis univariante, bivariante con prueba no paramétrica de Chi-cuadrado y regresión logística binaria se ellevó a cabo con el programa estadístico SPSS versión 21.0. Resultados: Participaron del estudio 213 personas. El consumo ≥ a 4 med…
Synthèse de pinces à fluorures dérivées d'aminoacides pour l'imagerie TEP
2014
This thesis project, which is part of a collaboration between the Institut de Chimie Moléculaire de l’Université de Bourgogne and the Positron Emission Tomography Research Centre, is about the synthesis of fluoride pincers derived from amino acids based on 18F-B bond construction to get a new class of PET imaging agents. First, this project concerned the design, synthesis and characterisation of new boronato and trifluoroborato phosphonium amino acid salts. Quaternisation of o-boronate phenyl phosphine with β-iodo amino esters or γ-iodo amino ester leads to the corresponding salts without racemisation and in yields up to 88%. Saponification of boronato phosphonium amino esters afford the fr…
Synthèse et formulation de résines photopolymérisables issues de la biomasse : application pour l'impression Braille
2014
The work of the PhD deals with the synthesis of polymerizable monomers derived from biomass, the study of their photopolymerization and the characterization of the resulting materials. The formulated monomers were tested in a printing method of Braille characters.The monomers were prepared in a two-steps reaction that is simple, economic and environmentally friendly. The first step comprised a reaction between glycerol derivatives (glycerol carbonate or glycidol) and fatty acids. In the second step, the obtained [alpha]-monoglycerides were functionalized to obtain photopolymerizable monomers. The different obtained monomers that bear (meth)acrylate and/or epoxy groups were photopolymerized …
P-chirogenic secondary phosphine oxides : new synthesis and applications
2015
A new stereoselective synthesis of phosphinous acid boranes is described by hydrolysis of aminophosphines boranes prepared by reaction of the oxazaphospholidine complex derived from ephedrine with organolithium reagents.By reaction with a strong acid, the phosphinous acid boranes lead to the corresponding P-chirogenic secondary phosphine oxides in very good yields (90%) and with complete retention of the configuration at the phosphorus atom. The secondary phosphine oxides have been used in asymmetric hydrogenation and intramolecular Heck cyclisation using rhodium and palladium complexes, respectively. In a second part, a new synthesis of P-chirogenic ortho-halogenophenyl phosphine oxides is…
Acidificación biológica de vinos de pH elevado mediante la utilización de bacterias lácticas
2014
Actualmente, se están observando las consecuencias del cambio climático en la vitivinivultura. En los últimos años se están generando cosechas más tempranas y uvas con una descompensación entre la madurez fenólica y la madurez industrial. Estas uvas generan mostos con una elevada concentración de azúcares y una baja concentración de ácidos, que dan lugar a vinos con una alta concentración de etanol, una baja AT y un elevado pH. Los vinos de pH elevado presentan varios inconvenientes. Son vinos planos y sin frescor, tienen una elevada inestabilidad microbiológica y generan una disminución en la capacidad antiséptica del anhídrido sulfuroso. El pH de los vinos puede descenderse mediante metod…
Evaluation of the toxicity of mussels from 2 sites of the Moroccan Atlantic Coast (Jorf Lasfar and Oualidia) used as bioindicators of contamination :…
2012
Toxic substances generated by various human activities are spilled on different area of the Moroccan coast. Shellfishes can concentrate pollutants and have some adverse effects on human health through the food chain. Despite the strengthening of food safety rules, the involvement of chemical pollution of food on metabolic disorders is not known. To predict the impact of pollutants on the aquatic ecosystem and human health, the development of appropriate biomonitoring tools is required.We quantified heavy metals (Cd, Cr and Pb) in mussels (Mytilus galloprovincialis) from two sites of Moroccan Atlantic coast (industrial site Jorf Lasfar (JL) and touristic site Oualidia (OL)) due to the proxim…
Conjugated linolenic acid (CLna), conjugated linoleic acid (CLA), and other biohydrogenation intermediates in plasma and milk fat of cows fed raw or …
2007
International audience; Thirty lactating dairy cows were used in a 333 Latin-square design to investigate the effects of a raw or extruded blend of linseed and wheat bran (70:30) on plasma and milk fatty-acids (FA). Linseed diets, containing 16.6% linseed blend on a dry-matter basis, decreased milk yield and protein percentage. They decreased the proportions of FA with less than 18 carbons in plasma and milk and resulted in cis -9, cis -12, cis -15 18:3 proportions that were more than three and four times higher in plasma and milk, respectively, whereas cis -9, cis -12 18:2 proportions were decreased by 10–15%. The cis -9, trans -11, cis -15 18:3 isomer of conjugated linolenic acid was not …
Acute in vivo administration of a fish oil-containing emulsion improves post-ischemic cardiac function in n-3-depleted rats
2006
International audience; A novel i.v. lipid preparation (MCT:FO) containing 80% medium chain-triacylglycerols and 20% fish oil was recently developed to rapidly replenish cell membrane phospholipids with omega 3 (n-3) polyunsaturated fatty acids (PUFA). In regard of this property, we investigated the effect of a single i.v. administration of MCT:FO on the recovery of cardiac function after ischemia in control and n-3-depleted rats. Results were compared with those obtained either with a control preparation, where FO was replaced by triolein (MCT:OO), or with saline. Saline (1 ml) or lipid preparation (also 1 ml) was injected as a bolus via the left saphenous vein. After 60 min the heart was …
Newborn screening and disease variants predict neurological outcome in isovaleric aciduria.
2021
Isovaleric aciduria (IVA), a metabolic disease with severe (classic IVA) or attenuated phenotype (mild IVA), is included in newborn screening (NBS) programs worldwide. The long-term clinical benefit of screened individuals, however, is still rarely investigated. A national, prospective, observational, multi-center study of individuals with confirmed IVA identified by NBS between 1998 and 2018 was conducted. Long-term clinical outcomes of 94 individuals with IVA were evaluated, representing 73.4% (for classic IVA: 92.3%) of the German NBS cohort. In classic IVA (N = 24), NBS prevented untimely death except in one individual with lethal neonatal sepsis (3.8%) but did not completely prevent si…