Search results for "acting"
showing 10 items of 338 documents
Metabolic comorbidities and male sex influence steatosis in chronic hepatitis C after viral eradication by direct-acting antiviral therapy (DAAs): Ev…
2021
Background: Chronic hepatitis C (CHC) is associated with hepatic steatosis, related to both a direct viral action and metabolic features. Vice-versa data on hepatic steatosis after viral eradication by direct-acting antiviral agents (DAA) are undefined although the presence of metabolic alterations could strongly influence the occurrence of steatosis as in NAFLD. The controlled attenuation parameter (CAP) (FibroscanⓇ) allows the qualitative and quantitative evaluation of fatty liver. Aim: to evaluate in patients with CHC whether hepatic steatosis diagnosed by CAP modifies after DAAs-induced sustained virologic response (SVR). Methods: Data were collected the day of DAAs therapy starting and…
The Boson Fermion Correspondence
1989
In 1932 Louis de Broglie suggested that photons could be constructed from pairs of neutrinos [de Broglie, 1932]. Both are massless particles (except for some recent unconfirmed experiments according to which the neutrino could have a very small mass) and are electrically neutral. The main difference between free photons and free neutrinos is that the former obeys Bose statistics and the second Fermi statistics. The spin of a photon is 1 and the spin of a neutrino is 1/2 and therefore kinematically it should be possible to think of a photon as a neutrino pair. However, this old formulation of boson fermion equivalence has not been very fruitful in particle physics. Instead, there has been a …
Understanding the Dynamic Effect of Contracting Out on the Delivery of Local Public Services
2015
Máñez J., Pérez-López G., Prior D. and Zafra-Gómez J. L. Understanding the dynamic effect of contracting out on the delivery of local public services, Regional Studies. Contracting out is a mechanism through which the delivery of public services can be made more efficient. However, the process has yielded conflicting results. This paper presents a dynamic, mixed approach, incorporating an intertemporal frontier and a matching technique, to measure the short- and long-term effects of the implementation of contracting out on the efficiency of local public service delivery. The study demonstrates the existence of temporary inefficiency arising from the change in service management when contrac…
Improvements in aggregate-paste interface by the hydration of steelmaking waste in concretes and mortars
2019
[EN] The objective of the experimental work is to study the mechanical properties in self-compacting concretes (SCC) in which part of the limestone aggregate has been replaced by granulated blast furnace slag (GBFS) in different percentages ranging from 0% to 60%. The results show that at early ages the SCC with the largest content in slag tend to have lower compressive strengths due to the poor compacting of the aggregates, although in the long-term their strength increases due to the reactivity of the slag. In fact, at the age of 365 days, the mortars made with the substitution of 50% of cement by ground GBFS reach compressive strength similar to that of the mortar made with 100% of cemen…
Teachers’ training and inclusive processes in the kindergarten, primary and secondary school: a field research
2020
Inclusion is a continuous process aimed to promote learning and participation of all students, opposing every kind of exclusion and helping educative contexts to take charge diversity of life contexts, interests, experiences, knowledges and competences of students. For development of inclusive processes, teachers’ training represents a necessary change of paradigm in the secondary school that has to be even more organic and systemic. In fact, already in the report by OCSE in 2005, called “Teachers matter: attracting, development and retaining effective teachers”, it affirms that “improvement of quality of teachers’ training is a priority for the single national politics”. To renew the schol…
Active Fragments from Pro- and Antiapoptotic BCL-2 Proteins Have Distinct Membrane Behavior Reflecting Their Functional Divergence
2010
International audience; BACKGROUND:The BCL-2 family of proteins includes pro- and antiapoptotic members acting by controlling the permeabilization of mitochondria. Although the association of these proteins with the outer mitochondrial membrane is crucial for their function, little is known about the characteristics of this interaction.METHODOLOGY/PRINCIPAL FINDINGS:Here, we followed a reductionist approach to clarify to what extent membrane-active regions of homologous BCL-2 family proteins contribute to their functional divergence. Using isolated mitochondria as well as model lipid Langmuir monolayers coupled with Brewster Angle Microscopy, we explored systematically and comparatively the…
La drammatica
2014
The drammatica is a theatrical declamatory system that has been completely neglected since the dawn of the twentieth century; nevertheless it formed the foundation of the Italian national theatre and played a remarkable role in the history of eighteenth-and-nineteenth-century European theatre. It featured a scale of intonations and gestures which were represented by symbols of notation. Some of those symbols are still preserved and readable in the actors’ prompt books. My identification of the symbols demostrates the skilful craft of nineteenth-century Italian actors; but it also reveals the origins of an emerging resistance to the declamation, especially in the age of naturalism. Some of t…
Mitochondrial dynamics in type 2 diabetes: Pathophysiological implications
2017
Mitochondria play a key role in maintaining cellular metabolic homeostasis. These organelles have a high plasticity and are involved in dynamic processes such as mitochondrial fusion and fission, mitophagy and mitochondrial biogenesis. Type 2 diabetes is characterised by mitochondrial dysfunction, high production of reactive oxygen species (ROS) and low levels of ATP. Mitochondrial fusion is modulated by different proteins, including mitofusin-1 (MFN1), mitofusin-2 (MFN2) and optic atrophy (OPA-1), while fission is controlled by mitochondrial fission 1 (FIS1), dynamin-related protein 1 (DRP1) and mitochondrial fission factor (MFF). PARKIN and (PTEN)-induced putative kinase 1 (PINK1) partici…
Current and future challenges in HCV: insights from an Italian experts panel
2017
Background: The recent availability of direct acting antiviral drugs (DAAs) has drastically changed hepatitis C virus (HCV) treatment scenarios, due to the exceedingly high rates of sustained virological response (SVR) and excellent tolerability allowing for treatment at all disease stages. Methods: A panel of Italian experts was convened twice, in November 2016 and January 2017, to provide further support on some open issues and provide guidance for personalized HCV care, also in light of forthcoming regimens. Results and conclusions: Treatment recommendations issued by international and national liver societies to guide clinicians in the management of HCV infection are constantly updated …
Economies of diversification in microfinance: Evidence from quantile estimation on panel data
2020
Abstract Prior studies of the diversification-driven cost savings from the joint provision of credit and deposits in microfinance usually ignore the multi-way heterogeneity across MFIs which vary substantially in size, business model, target clientele and operate in diverse environments. Using a quantile panel data model with correlated effects capable of accommodating multiple heterogeneity, we show that the typical measurement of economies of diversification at the mean provides an incomplete and distorted picture of their magnitude and prevalence in the industry. While we find statistically significant estimates, they are modest for most small-size MFIs but are quite substantial for larg…