Search results for "active"
showing 10 items of 5361 documents
Synthesis and In Vitro Evaluation of a Photosensitizer-BODIPY Derivative for Potential Photodynamic Therapy Applications
2015
A new photosensitizer (1) based on the 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) scaffold has been synthesized. 1 is water soluble and showed an intense absorption band at 490 nm (e=77600 cm-1M-1) and an emission at 514 nm. In vitro toxicity of 1 in the presence of light and in darkness has been studied with HeLa, HaCaT, MCF-7, and SCC-13 cell lines. Moreover, internalization studies of 1 in these cell lines were also performed. These results suggested that 1 is more toxic for SCC-13 and HeLa carcinoma cells than for the HaCaT noncancerous immortal human keratinocytes. Toxicity upon light irradiation was due to the formation of singlet oxygen and reactive oxygen species (ROS). Cel…
Regulation and role of nitric oxide production in Arabidopsis thaliana defense responses induced by oligogalacturonides
2014
SPEIPM; International audience
Impaired cognitive control in patients with brain tumors
2021
Though the assessment of cognitive functions is proven to be a reliable prognostic indicator in patients with brain tumors, some of these functions, such as cognitive control, are still rarely investigated. The objective of this study was to examine proactive and reactive control functions in patients with focal brain tumors and to identify lesioned brain areas more at "risk" for developing impairment of these functions. To this end, a group of twenty-two patients, candidate to surgery, were tested with an AX-CPT task and a Stroop task, along with a clinical neuropsychological assessment, and their performance was compared to that of a well-matched healthy control group. Although overall ac…
Biowaiver Monograph for Immediate-Release Solid Oral Dosage Forms: Moxifloxacin Hydrochloride.
2020
Abstract In this monograph, literature data is reviewed to evaluate the feasibility of waiving in vivo bioequivalence testing and instead applying the Biopharmaceutics Classification System (BCS) based methods to the approval of immediate-release solid oral dosage forms containing moxifloxacin hydrochloride as the sole active pharmaceutical ingredient. To facilitate the feasibility decision, solubility and permeability and dissolution characteristics in the context of the BCS, therapeutic index, therapeutic use, pharmacokinetic parameters, bioequivalence/bioavailability issues, drug-excipient interactions and other relevant data were taken into consideration. Moxifloxacin is a BCS class I d…
Effects of cadmium chloride on some mitochondria-related activity and gene expression of human MDA-MB231 breast tumor cells.
2007
It was reported that cadmium is able to exert a cytotoxic effect on tumor MDA-MB231 cells, which shows signs of "non-classical" apoptosis and is characterized by drastic changes in gene expression pattern. In this study, we have extended our knowledge of metal-breast cancer cell interactions by analyzing some mitochondria-related aspects of the stress response to CdCl(2) at either 5 or 50 microM 24- or 96-h exposure, by cytochemical, conventional PCR and Northern/Western blot techniques. We demonstrated that (i) no modification of the mitochondrial mass was detectable due to CdCl(2) exposure; (ii) the respiration activity appeared to be increased after 96-h exposures, while the production o…
Monitoring the Morphology of M87* in 2009-2017 with the Event Horizon Telescope
2020
All authors: Wielgus, Maciek; Akiyama, Kazunori; Blackburn, Lindy; Chan, Chi-kwan; Dexter, Jason; Doeleman, Sheperd S.; Fish, Vincent L.; Issaoun, Sara; Johnson, Michael D.; Krichbaum, Thomas P.; Lu, Ru-Sen; Pesce, Dominic W.; Wong, George N.; Bower, Geoffrey C.; Broderick, Avery E.; Chael, Andrew; Chatterjee, Koushik; Gammie, Charles F.; Georgiev, Boris; Hada, Kazuhiro Loinard, Laurent; Markoff, Sera; Marrone, Daniel P.; Plambeck, Richard; Weintroub, Jonathan; Dexter, Matthew; MacMahon, David H. E.; Wright, Melvyn; Alberdi, Antxon; Alef, Walter; Asada, Keiichi; Azulay, Rebecca; Baczko, Anne-Kathrin; Ball, David; Baloković, Mislav; Barausse, Enrico; Barrett, John; Bintley, Dan; Boland, Wilf…
Multiband RadioAstron space VLBI imaging of the jet in quasar S5 0836+710
2019
Open Access article, published by EDP Sciences, under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.-- Open Access funding provided by Max Planck Society.
Relativistic beaming and gamma-ray brightness of blazars
2009
We investigate the dependence of gamma-ray brightness of blazars on intrinsic properties of their parsec-scale radio jets and the implication for relativistic beaming. By combining apparent jet speeds derived from high-resolution VLBA images from the MOJAVE program with millimetre-wavelength flux density monitoring data from Metsahovi Radio Observatory, we estimate the jet Doppler factors, Lorentz factors, and viewing angles for a sample of 62 blazars. We study the trends in these quantities between the sources which were detected in gamma-rays by the Fermi Large Area Telescope (LAT) during its first three months of science operations and those which were not detected. The LAT-detected blaz…
Magnesium recovery from exhausted brine
2015
Mg and MgCO3 are among the 20 EU critical raw materials. Interestingly, Mg can be found at very high concentration in brines generated as waste stream from salt works. Literature works have demonstrated the feasibility of Mg extraction from brines [1–3] by reactive precipitation, for the production of Mg(OH)2. Here we present an overview of the experimental campaigns carried out using exhausted brine from real salt works (Italy) to produce Mg(OH)2 with high purity and conversion. Lab – and pilot-scale batch and semi-continuous CSTR crystallisers were developed and tested, eventually leading to a continuous process by a quasi-PFR pilot reactor. Different alkaline solutions have been adopted …
A continuous plug flow reactor for magnesium recovery from concentrated brine
2015
Magnesium is one of the eight most abundant elements on the world and the third most abun- dant in the sea, buc practically only two countries (Russia and China) control the world market for this compound. Product purity, Mg recovery, crystal morphology and granulometric distribution of precipitated particles were examined through careful laboratory analysis and results from different tests were compared, in order to identify the effect of allcaline species’ nature and concentration on precipitation phenomena.