Search results for "activity"
showing 10 items of 7178 documents
New tricyclic systems as photosensitizers towards triple negative breast cancer cells.
2022
AbstractNineteen pyrrolo[1,2-h][1,7]naphthyridinones and pyrido[2,3-c]pyrrolo[1,2-a]azepinones were synthesized as new tricyclic systems in which the pyridine ring is annelated to the 6,7-dihydroindolizin-8(5H)-one and 5,6,7,8-tetrahydro-9H-pyrrole[1,2-a]azepine-9-one moieties to obtain potential photosensitizing agents. They were tested for their photoantiproliferative activity on a triple-negative breast cancer cell line, MDA-MB-231, in the dark and under UVA light (2.0 J/cm2). We demonstrated that their toxicity, only when exposed to light, was primarily due to the generation of reactive oxygen species while their photodegradation products were not responsible for their activity. The mos…
New Tripentone Analogs with Antiproliferative Activity
2017
Tripentones represent an interesting class of compounds due to their significant cytotoxicity against different human tumor cells in the submicro-nanomolar range. New tripentone analogs, in which a pyridine moiety replaces the thiophene ring originating the fused azaindole system endowed with anticancer activity viz 8H-thieno[2,3-b]pyrrolizinones, were efficiently synthesized in four steps with fair overall yields (34–57%). All tripentone derivatives were tested in the range of 0.1–100 μM for cytotoxicity against two human tumor cell lines, HCT-116 (human colorectal carcinoma) and MCF-7 (human breast cancer). The most active derivative, with GI50 values of 4.25 µM and 20.73 µM for HCT-116 a…
The intensity contrast of solar photospheric faculae and network elements : II. Evolution over the rising phase of solar cycle 23
2006
We studied the radiative properties of small magnetic elements (active region faculae and the network) during the rising phase of solar cycle 23 from 1996 to 2001, determining their contrasts as a function of heliocentric angle, magnetogram signal, and the solar cycle phase. We combined near-simultaneous full disk images of the line-of-sight magnetic field and photospheric continuum intensity provided by the MDI instrument on board the SOHO spacecraft. Sorting the magnetogram signal into different ranges allowed us to distinguish between the contrast of different magnetic structures. We find that the contrast center-to-limb variation (CLV) of these small magnetic elements is independent of …
Pain Neuroscience Education and Physical Therapeutic Exercise for Patients with Chronic Spinal Pain in Spanish Physiotherapy Primary Care: A Pragmati…
2020
Producción Científica
Transverse momentum spectra and nuclear modification factors of charged particles in pp, p-Pb and Pb-Pb collisions at the LHC
2018
We report the measured transverse momentum ($p_{\rm T}$) spectra of primary charged particles from pp, p-Pb and Pb-Pb collisions at a center-of-mass energy $\sqrt{s_{\rm NN}} = 5.02$ TeV in the kinematic range of $0.15<p_{\rm T}<50$ GeV/$c$ and $|\eta|< 0.8$. A significant improvement of systematic uncertainties motivated the reanalysis of data in pp and Pb-Pb collisions at $\sqrt{s_{\rm NN}} = 2.76$ TeV, as well as in p-Pb collisions at $\sqrt{s_{\rm NN}} = 5.02$ TeV, which is also presented. Spectra from Pb-Pb collisions are presented in nine centrality intervals and are compared to a reference spectrum from pp collisions scaled by the number of binary nucleon-nucleon collisions. For cent…
Un campo científico en busca de visibilidad. Jornadas internacionales sobre la calidad de las revistas de Ciencias de la Actividad Física y el Deporte
2008
El campo de las Ciencias de la Actividad Física y el Deporte (CCAFD) en España necesita de actuaciones que contribuyan a mejorar la calidad de sus publicaciones periódicas. De esta manera las revistas pueden convertirse en órganos eficientes de comunicación y difusión del conocimiento científico creado por sus investigadores. En este trabajo se detalla la realización de las “Jornadas internacionales sobre la calidad de las revistas de ciencias de la actividad física y el deporte” celebradas en Valencia el 25 y 26 de octubre de 2007. Durante esos días se discutió sobre distintas visiones de la calidad de las revistas, ejemplos de gestión editorial y estrategias concretas de mejora. Con estas…
Effects of an incremental maximal endurance exercise stress-induced cortisol on cognitive performance
2019
Exercise; Cognitive functions; Cortisol Ejercicio físico; Funciones cognitivas; Cortisol Exercici físic; Funcions cognitives; Cortisol Objectives: It can be hypothesized that cognitive performance decreases after fatigue protocol when it coincides with the maximum peak of cortisol. The first aim of this study was to elucidate the effects of a single bout of high intensity exercise on behavioural (i.e., attention and memory) and physiological (i.e., salivary cortisol) responses. The second objective was to evaluate the effect of the performance of the cognitive tasks on cortisol levels. Methods: Thirty-four physically active men (at least 5 days/week of physical activity practice) 38.11 (1.5…
Chemical Composition and antimicrobial activity of the essential oils from two species of Thimus growing wild in southern Italy
2009
The volatile constituents of the aerial parts of two samples of Thymus longicaulis C. Presl, collected in Campania and in Sicily, and two samples of Thymus pulegioides L. from the same regions, were extracted by hydrodistillation and analyzed. Considering the four oils together, seventy-eight different compounds were identified: 57 for Thymus longicaulis from Sicily (91.1% of the total oil), 40 for Thymus longicaulis from Campania (91.5% of the oil), 39 for Thymus pulegioides from Sicily (92.5% of the oil) and 29 for Thymus pulegioides from Campania (90.1% of the oil). The composition of the oils is different, although the most abundant components are identical in T. pulegioides. The essent…
Comparative Analysis of Machine Learning Methods to Predict Growth of F. sporotrichioides and Production of T-2 and HT-2 Toxins in Treatments with Et…
2021
The efficacy of ethylene-vinyl alcohol copolymer films (EVOH) incorporating the essential oil components cinnamaldehyde (CINHO), citral (CIT), isoeugenol (IEG), or linalool (LIN) to control growth rate (GR) and production of T-2 and HT-2 toxins by Fusarium sporotrichioides cultured on oat grains under different temperature (28, 20, and 15 °C) and water activity (aw) (0.99 and 0.96) regimes was assayed. GR in controls/treatments usually increased with increasing temperature, regardless of aw, but no significant differences concerning aw were found. Toxin production decreased with increasing temperature. The effectiveness of films to control fungal GR and toxin production was as follows: EVOH…
A New Bloody Pulp Selection of Myrobalan (Prunus cerasifera L.): Pomological Traits, Chemical Composition, and Nutraceutical Properties
2023
A new accession of myrobalan (Prunus cerasifera L.) from Sicily (Italy) was studied for the first time for its chemical and nutraceutical properties. A description of the main morphological and pomological traits was created as a tool for characterization for consumers. For this purpose, three different extracts of fresh myrobalan fruits were subjected to different analyses, including the evaluation of total phenol (TPC), flavonoid (TFC), and anthocyanin (TAC) contents. The extracts exhibited a TPC in the range 34.52–97.63 mg gallic acid equivalent (GAE)/100 g fresh weight (FW), a TFC of 0.23–0.96 mg quercetin equivalent (QE)/100 g FW, and a TAC of 20.24–55.33 cyanidine-3-…