Search results for "adrenalectomy"
showing 10 items of 43 documents
Regulation of argininosuccinate synthetase level by corticosteroid and pancreatic hormones during perinatal period.
1995
The urea cycle takes place in the hepatocyte of ureothelic animals. The conversion of ammonia into urea involves five reactions. The first 2 take place in the matrix of the mitochondria, the last 2 occur in the cytosol. Argininosuccinate synthetase (AS) is the third reaction of the urea cycle. It catalyses the condensation of citrulline and aspartate into arginonosuccinate. We have previously reported that rat AS activity was present in the cytosol and the outer membrane of the mitochondria. We have shown that, at the activity level, the colocation of AS was changing during fetal and neonatal development and was under the control of corticosteroid and pancreatic hormones. However, an unreso…
Adrenalectomy for solid tumor metastases: Results of a multicenter European study
2013
Background. We assessed the results of adrenalectomy for solid tumor metastases in 317 patients recruited from 30 European centers. Methods. Patients with histologically proven adrenal metastatic disease and undergoing complete removal(s) of the affected gland(s) were eligible. Results. Non-small cell lung cancer (NSCLC) was the most frequent tumor type followed by colorectal and renal cell carcinoma. Adrenal metastases were synchronous (#6 months) in 73 (23%) patients and isolated in 213 (67%). The median disease-free interval was 18.5 months. Laparoscopic resection was used in 46% of patients. Surgery was limited to the adrenal gland in 73% of patients and R0 resection was achieved in 86%…
Time course of development of transtubular sodium concentration differences in proximal surface tubules of the rat kidney. Micropuncture experiments …
1969
Int the proximal and distal surface tubules isotonic Na reabsorption (Φ Naout) is impaired by adrenalectomy. In the present experiments the time course of development of transtubular Na concentration differences (Na)P−(Na)TF was studied in the proximal convolution. 1. Na concentration was measured in free flow mannitol diuresis. Endproximal (Na)P−(Na)TF averaged 23.0±0.5 meq/l after 8.5±0.6 sec (controls) and 15.2±1.7 meq/l after 13.6±0.5 sec (adrenalectomized rats). 2. In modified stopped flow experiments tubular fluid, aspirated at the beginning of the proximal convolution in mannitol diuresis, was injected between two oil columnes and reaspirated after 28–36 sec of contact time. (Na)P−(N…
Correlation between the effects of retinoic acid and dexamethasone on liver tyrosine aminotransferase
1997
A single dose of 50 microg of trans-retinoic acid administered to rats significantly raised the level of hepatic tyrosine after a few hours. This effect was compared with that of dexamethasone and a possible correlation between these effectors was also investigated. An equal increase in enzyme activity level caused by retinoic acid was observed in adrenalectomized rats, leading to the suggestion that the effect of retinoic acid on liver tyrosine aminotransferase is independent of glucocorticoids. However, the study of the binding activity of the liver nuclear glucocorticoid receptors vs dexamethasone showed that this activity is favoured by retinoic acid, whereas no variation was evidenced …
A Case of Stage IV Chromophobe Renal Cell Carcinoma Treated with the Oncolytic ECHO-7 Virus, Rigvir®
2019
Patient: Male, 59 Final Diagnosis: Chromophobe renal cell carcinoma, stage IV Symptoms: Discomfort in the right hypochondrium Medication: Oncolytic virus Rigvir Clinical Procedure: Nephro-adrenalectomy Specialty: Oncology Objective: Unusual or unexpected effect of treatment Background: Renal cell carcinoma is the most commonly diagnosed primary malignant tumor of the kidney in adults, and includes the variant of chromophobe renal cell carcinoma. Despite new targeted therapies that improve progression-free survival (PFS) and overall survival (OS) for early-stage renal cell carcinoma, the 5-year survival for patients with stage IV renal cell carcinoma remains below 10%, and the 50% OS is less…
Adrenal myelolipoma associated with adenoma
2004
The association of an adrenal myelolipoma with a non-functioning adenoma is very rare. Herein, we report on such a case in an asymptomatic 64-year-old woman. To the best of our knowledge, there is only one other case of non-functioning adrenocortical adenoma associated with myelolipoma in the same gland. Furthermore, only two other adenomas (mineral corticoids and corticosteroid producing tumors) associated with myelolipomas have been reported, and both myelolipomas were less than 1 cm in size. In conclusion, the 8.5 cm myelolipoma in our case is the largest compared with the three previously reported ones.
Open Radical Nephrectomy: 35 Years of Experience at the “Luciano Giuliani” Urological Department of the University of Genoa
2006
Objective: Radical nephrectomy remains the gold standard for surgically resectable kidney neoplasms > 4 cm and, in selected cases, also in presence of metastatic disease. We reviewed the records of the patients having surgery at the University of Genoa in the last 35 yr. Methods: We have retrospectively assessed all the radical nephrectomies performed between 1970 and 2005. Among tumours of the kidney subjected to surgical treatment during this period, we found 1105 cases of histologically proven renal cell carcinoma (RCC), 965 of which had records available for the study. The number of cases per year, symptoms at diagnosis, surgical strategy, staging of the tumour, and survival were rev…
Die renale Elektrolytausscheidung normaler und adrenalektomierter Ratten nach intraven�sen Salzinjektionen und ihre Beeinflussung durch Corticosteroi…
1959
Groups of normal rats of both sexes in moderate water diuresis received i.v. injections of 5 ml./kg, of hypertonic (5 times isoosmotic) solutions of sodium chloride, mannitol er sodium sulfate. The renal excretion of water, sodium, chloride and potassium in a 30 minute-period following this injection was measured. It was compared to control values obtained 40 minutes earlier in the same animals after an i.v. injection of isotonic glucose solution. All hypertonic solutions increased diuresis, natriuresis, chloruresis and kaliuresis. While the effects of mannitol and sodium chloride were comparable, sodium sulfate was more natriuretic and less chloruretic. The excretion of potassium after inj…
Aufnahme und renale Ausscheidung von Wasser und Salzen bei freiem Nahrungs- und Trinkfl�ssigkeitsangebot; ihre Beeinflussung durch Adrenalektomie und…
1959
Water, sodium, potassium and chloride balances, food uptake and changes in body weight were determined in large groups of adrenalectomized or sham-operated rats having permanent access to water, 0.9 per cent saline and rat crackers. Measurements were done on the 5th to 8th day, or else on the 11th to 14th day after operation. From the 3rd day after operation the animals either received s.c. injections of 2.0 ml./kg. 0.9 per cent NaCl per day (controls) or of one of the following hormones: Corticotropin (25 U/kg. b.w./day), Cortisone acetate (12.5mg./kg./day), Cortexone acetate (7.5mg./kg./day) or D,L-Aldosterone acetate (0.15 mg./kg./day). Besides electrolyte balances, plasma concentrations…