Search results for "aid"
showing 10 items of 3031 documents
Trabajo no remunerado y trabajo negro en España
2005
enric.sanchis@uv.es El trabajo irregular y el no remunerado tienen una importancia considerable en el Estado español, por lo que el análisis de la estructura y evolución del empleo no puede hacerse al margen de ellos. En este artículo se ofrece una visión de conjunto de ambos fenómenos a partir de algunas de las investigaciones llevadas a cabo durante los últimos años. Casi la totalidad del trabajo no remunerado se hace en el ámbito de las relaciones familiares. Se calcula que dos tercios de la carga total de trabajo que soporta la economía española es trabajo doméstico no remunerado, mayoritariamente hecho por mujeres. No obstante, el trabajo voluntario no familiar equivale aproximadamente…
Neurobiological roots of language in primate audition : common computational properties
2015
Here, we present a new perspective on an old question: how does the neurobiology of human language relate to brain systems in nonhuman primates? We argue that higher-order language combinatorics, including sentence and discourse processing, can be situated in a unified, cross-species dorsal-ventral streams architecture for higher auditory processing, and that the functions of the dorsal and ventral streams in higher-order language processing can be grounded in their respective computational properties in primate audition. This view challenges an assumption, common in the cognitive sciences, that a nonhuman primate model forms an inherently inadequate basis for modeling higher-level language…
Ventajas de la aplicación del EFQM en la gestión de un centro de drogas
2010
Desde la puesta en marcha de los primeros recursos para la atención a las drogodependencias, esta labor, se materializa en el quehacer de los equipos multiprofesionales, que con los años han visto ampliada su composición para dar respuesta a un fenómeno dinámico, de salud pública, con aparición de nuevas drogas y nuevos perfiles de consumidores.No obstante, a pesar de la ampliación de recursos tanto materiales como profesionales en términos generales, puede afirmarse que en estos dispositivos se carece de la necesaria protocolización de la intervención, del mismo modo, la gestión de los centros se ha realizado sin la pertinente acreditación ni homologación. Esta situación provoca, entre otr…
New antitrichomonal drug-like chemicals selected by bond (edge)-based TOMOCOMD-CARDD descriptors.
2008
Bond-based quadratic indices, new TOMOCOMD-CARDD molecular descriptors, and linear discriminant analysis (LDA) were used to discover novel lead trichomonacidals. The obtained LDA-based quantitative structure-activity relationships (QSAR) models, using nonstochastic and stochastic indices, were able to classify correctly 87.91% (87.50%) and 89.01% (84.38%) of the chemicals in training (test) sets, respectively. They showed large Matthews correlation coefficients of 0.75 (0.71) and 0.78 (0.65) for the training (test) sets, correspondingly. Later, both models were applied to the virtual screening of 21 chemicals to find new lead antitrichomonal agents. Predictions agreed with experimental resu…
Flupirtine protects both neuronal cells and lymphocytes against induced apoptosis in vitro: Implications for treatment of AIDS patients
1999
In the present study we demonstrate that flupirtine, an already clinically used, centrally acting, non-opiate analgesic agent, protects rat cortical neurons against HIV-gp120 induced apoptotic cell death. The drug was active at concentrations between 1 and 10 microg/ml. Furthermore we show inhibition of in vitro induced apoptosis in human blood mononuclear cells, using flupirtine. Induced apoptosis in peripheral blood mononuclear cells from healthy individuals and HIV-1 infected patients was reduced to approximately 50% after in vitro preincubation with flupirtine at concentrations between 0.1 and 10 microg/ml. The anti-apoptotic effect of flupirtine was restricted to CD3+ lymphocytes and i…
Ketamine in acute phase of severe traumatic brain injury “an old drug for new uses?”
2021
AbstractMaintaining an adequate level of sedation and analgesia plays a key role in the management of traumatic brain injury (TBI). To date, it is unclear which drug or combination of drugs is most effective in achieving these goals. Ketamine is an agent with attractive pharmacological and pharmacokinetics characteristics. Current evidence shows that ketamine does not increase and may instead decrease intracranial pressure, and its safety profile makes it a reliable tool in the prehospital environment. In this point of view, we discuss different aspects of the use of ketamine in the acute phase of TBI, with its potential benefits and pitfalls.
Monoclonal antibodies with subnanomolar affinity to tenofovir for monitoring adherence to antiretroviral therapies: from hapten synthesis to prototyp…
2020
Approximately 32 million people have died of HIV infection since the beginning of the outbreak, and 38 million are currently infected. Among strategies adopted by the Joint United Nations Programme on HIV/AIDS to end the AIDS global epidemic, the treatment, diagnosis, and viral suppression of the infected subjects are considered crucial for HIV prevention and transmission. Although several antiretroviral (ARV) drugs are successfully used to manage HIV infection, their efficacy strictly relies on perfect adherence to the therapy, which is seldom achieved. Patient supervision, especially in HIV-endemic, low-resource settings, requires rapid, easy-to-use, and affordable analytical tools, such …
Herbal hepatotoxicity: a hidden epidemic
2011
Complementary and alternative therapies, including herbal products, have become increasingly popular in the general population and among patients and physicians. Regulations and pharmacovigilance regarding herbal drugs are still incomplete and need to be improved. In fact, herbals are commonly marketed on the Internet, and in many countries they are sold as food supplements, which are beyond the control of drug regulatory agencies. In Europe and the U.S., reports of hepatotoxicity from these products, including those advertised for liver diseases, are accumulating. Many herbal drugs are also commonly used in children, and in women during pregnancy and lactation, because they are believed to…
Négligence illicite et responsabilités multiples: partage ou cumul de responsabilités?
2018
This paper addresses the issue of the distribution of international responsibility between two or more States or between an international organization and its member States in case of violation of obligations of due diligence.
Comportements d'acteurs et dynamiques territoriales
1997
National audience; Notre projet est de concevoir un outil d'aide à la décision en matière d'aménagement urbain, s'appliquant aux stratégies de localisation des entreprises commerciales. Il est basé sur la modélisation des interactions entre des acteurs (décideurs, groupes d'agents socio-économiques) et leur territoire. Deux idées fortes sous-tendent ce projet. La première est que l'espace représente un type d 'acteur particulier, qui agit sur le comportement des agents socio-économiques et qui, en retour, est modifié par eux. La seconde consiste à intégrer le raisonnement des équipes municipales (qui sont les décideurs en matière d'aménagement urbain) dans le modèle, afin d'obtenir un outil…