Search results for "alanine aminotransferase"

showing 4 items of 14 documents

Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance

2022

Background & Aims Serum microRNA (miRNA) levels are known to change in non-alcoholic fatty liver disease (NAFLD) and may serve as useful biomarkers. This study aimed to profile miRNAs comprehensively at all NAFLD stages. Methods We profiled 2,083 serum miRNAs in a discovery cohort (183 cases with NAFLD representing the complete NAFLD spectrum and 10 population controls). miRNA libraries generated by HTG EdgeSeq were sequenced by Illumina NextSeq. Selected serum miRNAs were profiled in 372 additional cases with NAFLD and 15 population controls by quantitative reverse transcriptase PCR. Results Levels of 275 miRNAs differed between cases and population controls. Fewer differences were seen wi…

SCORING SYSTEMCPM counts per millionAUROC area under the receiver operating characteristicRC799-869AST aspartate aminotransferaseMicroRNA; Non-alcoholic fatty liver disease; Biomarker; SequencingTGF-β transforming growth factor-betaGastroenterologySTEATOHEPATITISLiver disease0302 clinical medicineFibrosismiRNA microRNAlogFC log2 fold changeFIBROSISImmunology and AllergySequencing0303 health scienceseducation.field_of_studyNAS NAFLD activity scoremedicine.diagnostic_testFatty liverGastroenterologyGTEx Genotype-Tissue ExpressionMicroRNADiseases of the digestive system. Gastroenterology3. Good healthReal-time polymerase chain reactionBiomarker MicroRNA Non-alcoholic fatty liver disease SequencingLiver biopsyACIDBiomarker (medicine)030211 gastroenterology & hepatologyLife Sciences & BiomedicineResearch ArticleEXPRESSIONmedicine.medical_specialtyNAFLD non-alcoholic fatty liver diseaseNASH non-alcoholic steatohepatitisPopulationGastroenterology and HepatologySAF steatosis–activity–fibrosisVALIDATIONER endoplasmic reticulum03 medical and health sciencescDNA complementary DNAInternal medicineALT alanine aminotransferaseGastroenterologiInternal MedicinemedicineNAFL non-alcoholic fatty liverALGORITHMFIB-4 fibrosis-4education030304 developmental biologyPCA principal component analysisScience & TechnologyGastroenterology & HepatologyHepatologybusiness.industryBiomarkerFC fold changemedicine.diseaseBiomarker; MicroRNA; Non-alcoholic fatty liver disease; Sequencingdigestive system diseasesFLIP fatty liver inhibition of progressionCt cycle thresholdSteatosisqPCR quantitative PCRbusinessNon-alcoholic fatty liver disease
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Zur frage: Psoriasis vulgaris und Leber

1964

Der wiederholt geauserten Meinung einer Krankheitskorrelation zwischen Psoriasis vulgaris und Leber wird durch Bestimmung fur die Leberdiagnostik besonders geeigneter Enzyme (Glutaminsaure-Oxalessigsaure-Transaminase, Glutaminsaure-Brenztraubensaure-Transaminase, Aldolase) und des Zweifarbstofftests sowie wiederholt auch des Serumgesamtbilirubins nachgegangen. In der uberwiegenden Zahl der Psoriasis vulgaris-Kranken konnten normale Befunde erhoben werden. Von 14 Psoriatikern mit vorwiegend nur gering von der Norm abweichenden Befunden konnte anamnestisch und klinisch zumeist die Ursache fur die pathologischen Serum veranderungen ermittelt werden, ohne das sich jedoch hieraus der Nachweis fu…

biologybusiness.industryPsoriasisAldolase Amedicinebiology.proteinDermatologyGeneral MedicineAlanine aminotransferasemedicine.diseasebusinessMolecular biologyArchiv f�r Klinische und Experimentelle Dermatologie
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Interferon for non-A, non-B chronic hepatitis

1991

Abstract We reviewed randomised clinical trials evaluating the effect of lymphoblastoid or recombinant α-interferon in non-A, non-B chronic hepatitis. The outcomes assessed were the rates of serum alanine aminotransferase normalization and relapse during and after stopping interferon. Data were pooled by meta-analysis and a 50% overall rate difference, favouring treated patients, was found. Results showed homogeneity in direction of treatment effect both after short-term (2–6 months, ≥ 2 mega-units thrice weekly) and long-term (9–18 months, variable dose) interferon course. Moreover, results did not change when type of publication (abstracts vs. full reports) and treatment duration or sched…

medicine.medical_specialtyChemotherapyHepatologybusiness.industrymedicine.medical_treatmentSurgeryClinical trialChronic hepatitisInterferonInternal medicineMeta-analysisMedicineDose reductionViral diseaseAlanine aminotransferasebusinessmedicine.drugJournal of Hepatology
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Effects of dietary dehydrated lemon peel on some biochemical markers related to general metabolism, welfare and stress in gilthead seabream (Sparus a…

2019

Dehydrated lemon peel (DLP) at two levels (1.5% and 3%) was included for 30 days in the diet of gilthead seabream (Sparus aurata L.) and after 15 and 30 days the serum and skin mucus of fish were analysed. In serum, both experimental diets led to an initial decrease in glucose and lactate after which the levels became comparable to the control. Dietary DLP modulated the activity of transaminases, alanine aminotransferase and aspartate aminotransferase. The total antioxidant status showed a progressive increase in relation to levels of inclusion of DLP and time of administration (p '.05). In skin mucus, some biomolecular markers related to general stress, oxidative stress and apoptosis exhib…

medicine.medical_specialtyGilthead Seabreamantioxidantdehydrated lemon peelAquatic ScienceBiologymedicine.disease_causegilthead seabream (Sparus aurata)antioxidants dehydrated lemon peel gilthead seabream (Sparus aurata) metabolism welfare03 medical and health sciencesSettore AGR/20 - ZoocoltureInternal medicinemedicineSettore BIO/06 - Anatomia Comparata E CitologiaAlanine aminotransferaseBiochemical markers030304 developmental biology0303 health sciencesLemon peel04 agricultural and veterinary sciencesMetabolismMucuswelfareEndocrinologyApoptosis040102 fisheries0401 agriculture forestry and fisheriesmetabolismOxidative stressAquaculture Research
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