Search results for "alpha-Linolenic Acid"

showing 5 items of 15 documents

Pathway of alpha-linolenic acid through the mitochondrial outer membrane in the rat liver and influence on the rate of oxidation. Comparison with lin…

1989

The movement of alpha-linolenic acid (C18:3, n-3) through the mitochondrial outer membrane to oxidation sites was studied in rat liver and compared with the movement of linoleic acid (C18:2, n-6) and oleic acid (C18:1, n-9). All differ in the degree of unsaturation, but have the same chain length and the same position of the first double bond when counted from the carboxyl end. The following results were obtained. (1) The overall beta-oxidation in total mitochondria was in the order C18:3, n-3 greater than C18:2, n-6 greater than C18:1, n-9, independent of the amount of albumin in the medium. (2) The rate of formation of acylcarnitine from acyl-CoA was higher with oleoyl-CoA than with linol…

MaleLinolenic AcidsLinoleic acidPotassiumchemistry.chemical_elementMitochondria LiverOleic AcidsMitochondrionIn Vitro TechniquesBiochemistryLinoleic Acidchemistry.chemical_compoundCarnitinemedicineAnimalsCarnitineMolecular BiologyDegree of unsaturationCarnitine O-PalmitoyltransferaseChemistryalpha-Linolenic acidBiological TransportRats Inbred StrainsCell BiologyIntracellular MembranesPeroxisomeRatsOleic acidBiochemistryLinoleic Acidslipids (amino acids peptides and proteins)Acyl Coenzyme AOxidation-Reductionmedicine.drugOleic AcidResearch ArticleThe Biochemical journal
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Hepatic farnesyl diphosphate synthase expression is suppressed by polyunsaturated fatty acids

2005

Dietary vegetable oils and fish oils rich in PUFA (polyunsaturated fatty acids) exert hypocholesterolaemic and hypotriglyceridaemic effects in rodents. The plasma cholesterol-lowering properties of PUFA are due partly to a diminution of cholesterol synthesis and of the activity of the rate-limiting enzyme HMG-CoA reductase (3-hydroxy-3-methylglutaryl-CoA reductase). To better understand the mechanisms involved, we examined how tuna fish oil and individual n−3 and n−6 PUFA affect the expression of hepatic FPP synthase (farnesyl diphosphate synthase), a SREBP (sterol regulatory element-binding protein) target enzyme that is subject to negative-feedback regulation by sterols, in co-ordination …

RNA StabilityBlotting WesternDown-RegulationReductaseBiochemistryGene Expression Regulation EnzymologicMicechemistry.chemical_compoundFish OilsFarnesyl diphosphate synthaseCell Line TumorAnimalsHumansRNA MessengerPromoter Regions GeneticMolecular BiologyTriglyceridesCell Nucleuschemistry.chemical_classificationAlkyl and Aryl TransferasesbiologyTunaCholesterolalpha-Linolenic acidalpha-Linolenic Acidfood and beveragesGeranyltranstransferaseCell BiologyHydroxymethylglutaryl-CoA reductaseEicosapentaenoic acidDietRatsDNA-Binding ProteinsCholesterolLiverchemistryBiochemistryDocosahexaenoic acidCCAAT-Enhancer-Binding ProteinsFatty Acids Unsaturatedbiology.proteinHydroxymethylglutaryl CoA Reductaseslipids (amino acids peptides and proteins)Sterol Regulatory Element Binding Protein 1Sterol Regulatory Element Binding Protein 2Transcription FactorsResearch ArticlePolyunsaturated fatty acidBiochemical Journal
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Nutrient intakes of children aged 1-2 years as a function of milk consumption, cows' milk or growing-up milk.

2012

AbstractObjectiveTo evaluate the nutritional adequacy of diets in early childhood as a function of milk intake, cows’ milk (CM) or growing-up milk (GUM).DesignFrom a cross-sectional food consumption survey, two groups of children aged 1–2 years were defined: Group CM fed exclusively on CM ≥ 250 ml/d and Group GUM fed on GUM ≥ 250 ml/d. Proportions of children at risk of nutrient excess or insufficiency were estimated relative to the French Recommended Daily Allowances, Estimated Average Requirements or Adequate Intakes.SettingParents participating in the survey were recruited from all regions of France by a polling organization. Distribution was adjusted to that of the French population.Sub…

VitaminAdultParentsIronPopulationMedicine (miscellaneous)Ascorbic AcidReference Daily IntakeDiet SurveysNutrition PolicyLinoleic Acidchemistry.chemical_compoundAnimal scienceRisk FactorsVitamin D and neurologyMedicineAnimalsHumansNutrition and HealthVitamin Deducationeducation.field_of_studyNutrition and DieteticsVitamin Calpha-Linolenic acidbusiness.industryPublic Health Environmental and Occupational HealthNutritional RequirementsInfantalpha-Linolenic AcidVitaminsAscorbic acidDietary FatsDietTrace ElementsCross-Sectional StudiesMilkNutrition AssessmentchemistryDietary Reference IntakeChild PreschoolFood FortifiedCattleDietary ProteinsFrancebusinessDeficiency DiseasesEnergy IntakeIron DietaryPublic health nutrition
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Revisiting delta-6 desaturase regulation by C18 unsaturated fatty acids, depending on the nutritional status.

2009

Dietary polyunsaturated fatty acids (PUFA) play a key role in regulating delta-6 desaturase (D6D), the key enzyme for long-chain PUFA biosynthesis. Nevertheless, the extent of their effects on this enzyme remains controversial and difficult to assess. It has been generally admitted that C18 unsaturated fatty acids (UFAs) regulate negatively delta-6 desaturase (D6D). This inhibition has been evidenced in regard to a high glucose/fat free (HG/FF) diet used in reference. However, several nutritional investigations did not evidence any inhibition of desaturases when feeding fatty acids. Because the choice of the basal diet appeared to be of primary importance in such experiments, our goal was t…

chemistry.chemical_classificationalpha-Linolenic acidLinoleic acidGeneral MedicineBiologyBiochemistryDietary FatsLinoleoyl-CoA DesaturaseDelta-6-desaturaseRatschemistry.chemical_compoundOleic acidVegetable oilBiochemistrychemistryBiosynthesisGene Expression RegulationFatty Acids Omega-3Fatty Acids UnsaturatedAnimalsHumansSpecific activityFood scienceRats WistarPolyunsaturated fatty acidBiochimie
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Platelet and Plasmatic Lipidic Profile as Potential Marker of Bipolar Disorders: Preliminary Findings

2017

IntroductionAlthough the diagnosis of bipolar disorder is currently based on clinical criteria, preliminary studies showed that palmitic and arachidonic acid levels are able to discriminate adult patients with major depressive disorder (MDD) from those with bipolar disorder (BD).ObjectivesTo replicate and to expand previous findings by investigating the relation between mood disorders and platelet and plasmatic fatty levels.AimsTo compare the lipidic profile of individuals with different mood disorder (MDD vs. BD) and to investigate the relation with specific clinical features (duration of illness, attempted suicide, psychotic symptoms).MethodsPotential participants were recruited from the …

chemistry.chemical_classificationmedicine.medical_specialtymajor depressive disordersalpha-Linolenic acidFatty acidstearic acidmedicine.diseasePsychiatry and Mental healthchemistry.chemical_compoundMoodchemistryMood disordersDocosahexaenoic acidInternal medicinemedicineMajor depressive disorderArachidonic acidBipolar disorderPsychologyPsychiatryarachidonicEuropean Psychiatry
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