Search results for "alpha2beta1-Integriini"

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Echovirus 1 infektion vaikutus epidermaalisen kasvutekijäreseptorin endosytoosiin ja signalointiin

2013

Epidermaalinen kasvutekijäreseptori (EGFR) on yhdessä kollageeni- ja lamiinireseptori α2β1-integriinin kanssa tärkeä tekijä solun selviytymisen, kiinnittymisen ja jakautumisen säätelemisessä sekä syöpäsoluissa. Kasvutekijän sitoutumisen jälkeen EGFR:t dimerisoituvat, endosytoituvat klatriinivälitteisen endosytoosin kautta ja kulkeutuvat solun sisällä kolmen eri reitin mukaisesti: 1) EGFR-ligandi-kompleksi voi ubikitinaation seurauksena päätyä lysosomaaliseen pH:sta riippuvaan hajoitukseen, EGFR kierrättyy takaisin solukalvolle 2) ligandin irtoamisen tai 3) UBPY de-ubikitinaatioenstyymin toimesta. α2β1-integriinireseptori klusteroituu solukalvolle kiinnityttyään kollageeniin, lamiiniin, Echo…

alpha2beta1-IntegriiniEndosomaalinen kuljetusEpidermaalinen kasvutekijäreseptoriECHO-viruksetEchovirus 1endosytoosiProteiinikinaasi C

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PEPhysical Sciences and Engineering
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LSLife Sciences
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