Search results for "alternative"

Regulation of B cell homeostasis and activation by the tumor suppressor gene CYLD

2007

B cell homeostasis is regulated by multiple signaling processes, including nuclear factor-kappaB (NF-kappaB), BAFF-, and B cell receptor signaling. Conditional disruption of genes involved in these pathways has shed light on the mechanisms governing signaling from the cell surface to the nucleus. We describe a novel mouse strain that expresses solely and excessively a naturally occurring splice variant of CYLD (CYLD(ex7/8) mice), which is a deubiquitinating enzyme that is integral to NF-kappaB signaling. This shorter CYLD protein lacks the TRAF2 and NEMO binding sites present in full-length CYLD. A dramatic expansion of mature B lymphocyte populations in all peripheral lymphoid organs occur…

Equi-intensity across the SpectrumTM taste scales

2015

Abstract This work aimed to study the equi-intensity across the Spectrum™ taste scales. The approach consisted of a comparison of four reference points illustrating the same level of intensity across the scales using two very different methods: 2-alternative forced-choice (2-AFC) and Labeled Magnitude Scale (LMS). The comparisons across these scales were based on caffeine, citric acid, sodium chloride, sucrose, and monosodium glutamate in water solutions, at different concentrations, prepared according to the guidelines given for the Spectrum™ method. A scale concerning the umami taste, designed in the spirit of the Spectrum™ scales, was also studied in this work. Both procedures produced s…

Influence of Quality Filtering Approaches in BEC SMOS L3 Soil Moisture Products

2019

2019 IEEE International Geoscience and Remote Sensing Symposium (IGARSS 2019), 28 July - 2 August 2019, Yokohama, Japan

Could telemedicine enhance traditional medicine practices?

2014

International audience; In developing countries, telemedicine and mobile health tools promise to enhance access to high-quality healthcare, to support communication of medical information and to assist pharmacovigilance processes. In this article, we provide some arguments on the potential of telemedicine and mobile health (mHealth) applications to improve the delivery of health care in rural African regions. Specifically, the development of mobile telemedicine could help to lay the foundations of a healthcare approach integrating modern medical knowledge with ancient medical practices on the African continent. Access to information and communication technology (ICT), technical devices or p…

Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

2013

Journal article TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed ~480 SNPs at the TERT locus in breast (n = 103,991), ovarian (n = 39,774) and BRCA1 mutation carrier (n = 11,705) cancer cases and controls. Leukocyte telomere measurements were also available for 53,724 participants. Most associations cluster into three independent peaks. The minor allele at the peak 1 SNP rs2736108 associates with longer telomeres (P = 5.8 × 10!-7), lower risks for estrogen receptor (ER)-negative (P = 1.0 × 10!-8) and BRCA1 mutation carrier (P = 1.1 × 10!-5) breast cancers and altered promot…

Collective Intelligence, Information, Communication, Knowledge in an Alternative Culture of Development Driven by Well-Being for Any- and Everybody

2014

Crisis climática y desarrollo territorial. En busca de alternativas al capitalismo neoliberal desregulado

2020

Resumen. En el presente trabajo se pretende exponer cómo el enfoque del Desarrollo Territorial debe ser parte de las acciones globales por un mundo más justo, sostenible y solidario. Por ello he tratado de vincular en este texto las argumentaciones críticas y los movimientos sociales surgidos contra la crisis financiera, económica y social en los países desarrollados, con los movimientos sociales y socio-ambientales que se han levantado en América Latina y en otras partes del mundo en estas últimas décadas. A partir de una amplia y profunda reflexión teórica, derivada de la experiencia profesional adquirida en la promoción de iniciativas de Desarrollo Económico Local, tanto desde el punto d…

The Mathematicians’ Happy Hunting Ground: Einstein’s General Theory of Relativity

2004

There is hardly any doubt that for physics special relativity theory is of much greater consequence than the general theory. The reverse situation prevails with respect to mathematics: there special relativity theory had comparatively little, general relativity theory very considerable, influence, above all upon the development of a general scheme for differential geometry. —Hermann Weyl, “Relativity as a Stimulus to Mathematical Research,” pp. 536–537.

Seeing reality through Einstein's eyes: a teaching proposal for special relativity

2021

The teaching of Special Relativity is still a critical issue not only for students but also for teachers. In this paper, we describe the trial of a learning unit on the Special Relativity topic based on Minkowski's approach through spacetime diagrams, following the results in pedagogical researches in this field. The main innovation of our project consists of a mechanical instrument: it allows to physically and mechanically represent Lorentz’s transformations by hands, exploring the effects of a change of the reference frame. Teachers and students can deal “by eye” with unusual phenomena as the loss of simultaneity, time dilation, length contraction, relativistic addition of velocities and …

Prunella vulgaris L. Upregulates eNOS Expression in Human Endothelial Cells

2010

The purported effects of "circulation-improving" herbs used in traditional Chinese medicine (TCM) show striking similarities with the vascular actions of nitric oxide (NO) produced by the endothelial NO synthase (eNOS). We have previously reported that Salviae miltiorrhizae radix and Zizyphi spinosae semen upregulate eNOS expression. In the present study, we studied the effect on eNOS gene expression of 15 Chinese herbs with potential effects on the vasculature, and identified Prunella vulgaris L. (PVL) (flowering spike) as a potent eNOS-upregulating agent. In EA.hy 926 cells, a cell line derived from human umbilical vein endothelial cells (HUVEC), an aqueous extract of PVL increased eNOS …