Search results for "alternative"
showing 10 items of 1466 documents
Cīņa par varu Krievijas postimpērijas Rietumu perifērijā (1917–1920): teorētiskās un historiogrāfiskās problēmas
2014
Anotācija Promocijas darbā „Cīņa par varu Krievijas postimpērijas Rietumu perifērijā (1917–1920): teorētiskās un historiogrāfiskās problēmas” ir pētīts, kā mūsdienu vēstures literatūrā ir problematizēta cīņa par varu reģionā starp Baltijas jūru un Melno jūru (Somijas, Igaunijas, Latvijas, Lietuvas, Polijas, Baltkrievijas, Ukrainas teritorijās) periodā no carisma krišanas 1917. gada pavasarī līdz Polijas un Padomju Krievijas pamiera noslēgšanai 1920. gada rudenī. Darbs ir veikts, salīdzinoši analizējot priekšvēsturi cīņai par varu Krievijas postimpērijas Rietumu perifērijā, historiogrāfijā ietvertās cīņu definējošās koncepcijas, kā arī cīņas sekas un nozīmi jeb pēcvēsturi. Apzinoties pētniek…
Those who bridge the gaps : brokers and translators within development practices in Nepal
2015
Since the outburst of James Ferguson on the development policy in Lesotho in 1994 - the starting point of the post-development school of thought, the imposition of Western development models on Third World countries has been heavily criticized by post development thinkers. The purposes of what is called “development” are in serious doubt. “What do aid programmes do besides fail to help poor people?” (Ferguson, 1994: 180). Post-developmentalists, however, did not stop at castigating the reality they have witnessed on the ground; they also proposed solutions. They advocate for alternatives to development as a new development paradigm rather than alternative development (Escobar, 2000). As the…
The evolutionary dynamics of adaptive virginity, sex-allocation and altruistic helping in haplodiploid animals
2018
In haplodiploids, females can produce sons from unfertilized eggs without mating. However, virgin reproduction is usually considered to be a result of a failure to mate, rather than an adaptation. Here, we build an analytical model for evolution of virgin reproduction, sex-allocation, and altruistic female helping in haplodiploid taxa. We show that when mating is costly (e.g., when mating increases predation risk), virginity can evolve as an adaptive female reproductive strategy. Furthermore, adaptive virginity results in strongly divergent sex-ratios in mated and virgin queen nests ("split sex ratios"), which promotes the evolution of altruistic helping by daughters in mated queen nests. H…
Investigating the Antiproliferative and Antioxidant Properties of Pancratium maritimum L. (Amaryllidaceae) Stems, Flowers, Bulbs, and Fruits Extracts
2018
Pancratium maritimumstems, flowers, bulbs, and fruits extracts were investigated for their antiproliferative and antioxidant properties. Total phenols and total flavonoids were also determined. Thein vitroantiproliferative activity was tested against seven cancer cell lines such as C32, HeLa, MDA-MB-231, PC3, A549, MCF-7, and LNCaP by using SRB assay. Interesting results were obtained with stems ethanol extract (ET1) against C32 cells (IC50of 27.1μg/mL) and fruits aqueous extract (AQ) against MCF-7 cell line (IC50of 36.5μg/mL). To define the antioxidant activity, four tests such as DPPH, ABTS FRAP, andβ-carotene bleaching tests were used.The most promising ABTS scavenging capacity was obser…
Preclinical characterization of antagomiR-218 as a potential treatment for myotonic dystrophy
2021
Myotonic dystrophy type 1 (DM1) is a rare neuromuscular disease caused by expansion of unstable CTG repeats in a non-coding region of the DMPK gene. CUG expansions in mutant DMPK transcripts sequester MBNL1 proteins in ribonuclear foci. Depletion of this protein is a primary contributor to disease symptoms such as muscle weakness and atrophy and myotonia, yet upregulation of endogenous MBNL1 levels may compensate for this sequestration. Having previously demonstrated that antisense oligonucleotides against miR-218 boost MBNL1 expression and rescue phenotypes in disease models, here we provide preclinical characterization of an antagomiR-218 molecule using the HSALR mouse model and patient-d…
AUGMENTATIVE AND ALTERNATIVE COMMUNICATION (AAC) IN NEURODEVELOPMENTAL DISORDERS: A MINIREVIEW
2018
Children with neurodevelopmental disorders such as Autism Spectrum Disorders (ASD), cerebral palsy or severe motor speech disorders may beneficiate of augmentative and alternative communication (AAC) systems that may improve the developing language and the communication abilities. The term AAC tend to include each form of communication supplementing or replacing the natural speech production.
Atgriezeniskā dienas grāmata kā pedagoģiskais risinājums bērnu ar autisma spektra traucējumiem komunikatīvās kompetences veicināšanai
2018
Šajā Maģistra darbā tiek prezentēta inovatīva “atgriezeniskā dienas grāmata” kā pedagoģiskais risinājums (objekts) bērnu ar autisma spektra traucējumiem komunikatīvās kompetences attīstīšanai (priekšmets). Darbam ir 83 lpp., tā skaitā 2 tabulas, 9 attēli, 68 zinātniskās literatūras vienības un 3 pielikumi Ieraksti ko vecāki un skolotāji fiksē dienas grāmatā, atspoguļojot ikdienā veiktās aktivitātes un kritiskos notikumus, palīdz paredzēt attīstības grūtības un labāk izprast konkrētās situācijas. Tika pierādīts, ka šī metode veicina bērnu verbālās un neverbālās komunikācijas uzlabošanu, sekmējot viņu emocionāla uztraukuma samazināšanos, kā arī viņu iespējas sekmīgāk iekļauties darba tirgū un…
Liquidation of the Bankruptcy Estate in Poland
2020
The purpose of this study is to present the general principles and general issues of liquidation of the bankruptcy estate under Polish law. It should be stressed that liquidation of the bankruptcy estate is intended to satisfy the creditors of the insolvent debtor. Therefore, the manner of liquidation of the bankruptcy estate has an obvious impact on the final bankruptcy dividend for the creditors. The rules governing the liquidation of the bankrupt’s assets are of the key-importance for the theory of law and the practice. The article defines the directional principles of liquidation of the bankruptcy estate, procedure of liquidation of the bankruptcy estate. The subject of this paper there…
Search for intermediate mass black hole binaries in the first and second observing runs of the Advanced LIGO and Virgo network
2019
Gravitational wave astronomy has been firmly established with the detection of gravitational waves from the merger of ten stellar mass binary black holes and a neutron star binary. This paper reports on the all-sky search for gravitational waves from intermediate mass black hole binaries in the first and second observing runs of the Advanced LIGO and Virgo network. The search uses three independent algorithms: two based on matched filtering of the data with waveform templates of gravitational wave signals from compact binaries, and a third, model-independent algorithm that employs no signal model for the incoming signal. No intermediate mass black hole binary event was detected in this sear…
All-sky search in early O3 LIGO data for continuous gravitational-wave signals from unknown neutron stars in binary systems
2021
Rapidly spinning neutron stars are promising sources of continuous gravitational waves. Detecting such a signal would allow probing of the physical properties of matter under extreme conditions. A significant fraction of the known pulsar population belongs to binary systems. Searching for unknown neutron stars in binary systems requires specialized algorithms to address unknown orbital frequency modulations. We present a search for continuous gravitational waves emitted by neutron stars in binary systems in early data from the third observing run of the Advanced LIGO and Advanced Virgo detectors using the semicoherent, GPU-accelerated, binaryskyhough pipeline. The search analyzes the most s…