Search results for "alternative"
showing 10 items of 1466 documents
Awareness and understanding of cancer immunotherapy in Europe.
2014
3053 Background: Use of immunotherapies in the treatment of cancer is growing and a range of new immunotherapeutic strategies are being evaluated. It is important that healthcare providers (HCP) understand these treatments and how they compare with and may complement established therapies. As part of the activities of the POINT expert group, we commissioned a survey of current awareness, attitudes and perceptions of cancer immunotherapy in Europe. Methods: From August-September 2011, 426 healthcare professionals (HCPs: oncologists, surgeons and oncology nurses) from France, Germany, Italy, Spain and the UK (~85 respondents/country) completed online interviews. Representatives of patient ad…
Contact Sensitizers Specifically Increase MHC Class II Expression on Murine Immature Dendritic Cells
2000
Contact sensitivity is a T-cell-mediated immune disease that can occur when low-molecular-weight chemicals penetrate the skin. In vivo topical application of chemical sensitizers results in morphological modification of Langerhans cells (LC). Moreover, within 18 h, LC increase their major histocompatibility complex (MHC) class II antigens expression and migrate to lymph nodes where they present the sensitizer to T lymphocytes. We wanted to determine if such an effect could also be observed in vitro. However, because of the high genetic diversity encountered in humans, assays were performed with dendritic cells (DC) obtained from a Balb/c mouse strain. The capacity of a strong sensitizer, DN…
Protein Tyrosine Nitration Induced by Heme/Hydrogen Peroxide: Inhibitory Effect of Hydroxycinnamoyl Conjugates
2006
The present study was designed to optimize the experimental conditions that govern the heme-catalyzed nitration of protein tyrosine residues by nitrite, and, within this framework, to study the effects of 3,5-dicaffeoylquinic acid and its methyl ester, both of which have been previously reported to be antioxidants and inhibitors of leukocyte functions. Although the presence of hydrogen peroxide is essential in cell-free systems, an excess of this compound was found to be detrimental, so much so that an increase in hemin concentration actually resulted in an inverse effect on the reaction, depending on the levels of fixed hydrogen peroxide. Unlike previous reports on nitrite-induced albumin …
Digestive vacuole of Plasmodium falciparum released during erythrocyte rupture dually activates complement and coagulation.
2012
Abstract Severe Plasmodium falciparum malaria evolves through the interplay among capillary sequestration of parasitized erythrocytes, deregulated inflammatory responses, and hemostasis dysfunction. After rupture, each parasitized erythrocyte releases not only infective merozoites, but also the digestive vacuole (DV), a membrane-bounded organelle containing the malaria pigment hemozoin. In the present study, we report that the intact organelle, but not isolated hemozoin, dually activates the alternative complement and the intrinsic clotting pathway. Procoagulant activity is destroyed by phospholipase C treatment, indicating a critical role of phospholipid head groups exposed at the DV surfa…
Massless positivity in graviton exchange
2021
We formulate Positivity Bounds for scattering amplitudes including exchange of massless particles. We generalize the standard construction through dispersion relations to include the presence of a branch cut along the real axis in the complex plane for the Maldestam variable $s$. In general, validity of these bounds require the cancellation of divergences in the forward limit of the amplitude, proportional to $t^{-1}$ and $\log(t)$. We show that this is possible in the case of gravitons if one assumes a Regge behavior of the amplitude at high energies below the Planck scale, as previously suggested in the literature, and that the concrete UV behaviour of the amplitude is uniquely determined…
Infrared lessons for ultraviolet gravity: the case of massive gravity and Born-Infeld
2014
We generalize the ultraviolet sector of gravitation via a Born-Infeld action using lessons from massive gravity. The theory contains all of the elementary symmetric polynomials and is treated in the Palatini formalism. We show how the connection can be solved algebraically to be the Levi-Civita connection of an effective metric. The non-linearity of the algebraic equations yields several branches, one of which always reduces to General Relativity at low curvatures. We explore in detail a {\it minimal} version of the theory, for which we study solutions in the presence of a perfect fluid with special attention to the cosmological evolution. In vacuum we recover Ricci-flat solutions, but also…
On gravitational waves in Born-Infeld inspired non-singular cosmologies
2017
We study the evolution of gravitational waves for non-singular cosmological solutions within the framework of Born-Infeld inspired gravity theories, with special emphasis on the Eddington-inspired Born-Infeld theory. We review the existence of two types of non-singular cosmologies, namely bouncing and asymptotically Minkowski solutions, from a perspective that makes their features more apparent. We study in detail the propagation of gravitational waves near these non-singular solutions and carefully discuss the origin and severity of the instabilities and strong coupling problems that appear. We also investigate the role of the adiabatic sound speed of the matter sector in the regularisatio…
Correlation patterns from massive phonons in 1+1 dimensional acoustic black holes: A toy model
2018
Transverse excitations in analogue black holes induce a mass like term in the longitudinal mode equation. With a simple toy model we show that correlation functions display a rather rich structure characterized by groups of parallel peaks. For the most part the structure is completely different from that found in the massless case.
Comment: What is Alternative Technology? A Reply to Professor Stanley Carpenter
1983
Modern man is dissatisfied with the technology we have and would replace it with another. Three very different reasons are given for this. I will divide my treatment of them under three headings, listing the reason in each case together with a reply.
Intersecciones críticas. Experiencias y estrategias desde la museología y el feminismo gitano, bajo el prisma del covid-19 = Critical Intersections. …
2020
La pandemia de 2020 enfrentó las áreas que tratan la memoria desde los márgenes con la necesidad de transformar sus experiencias en estrategias con potencial de futuro. El artículo busca reflejar la intersección entre dos campos de acción cultural comprometida: el de algunos museos valencianos y el de las asociaciones de mujeres gitanas, vistas también desde el ámbito local. El objeto de nuestro análisis son dos vertientes de la actuación cultural emancipadora: las experiencias, fenómenos a menudo caóticos y coyunturales, y las estrategias razonadas, que unen prácticas del conocimiento crítico hasta ahora no contiguas. El estado de alarma definió estas ramas estratégicas como inclusión digi…