Search results for "alternative"
showing 10 items of 1466 documents
Adaptogens in chemobrain (Part I): Plant extracts attenuate cancer chemotherapy-induced cognitive impairment – Transcriptome-wide microarray profiles…
2019
Abstract Background Cancer chemotherapy-induced cognitive impairments are presumably associated with undesirable effects of chemotherapy on physiological functions of brain cells. Adaptogens are natural compounds or plant extracts increasing an organism's adaptability and survival in stress. They exhibited neuroprotective effects and increased cognitive functions in clinical studies in human beings. Hypothesis We hypothesized that selected adaptogenic plant extracts attenuate or prevent cancer chemotherapy-induced cognitive impairments. Aim We assessed the effects of selected adaptogenic herbal extracts on FEC (fixed combination 5-fluorouracil, epirubicin and cyclophosphamide) induced chang…
Factors Determining Sensitivity and Resistance of Tumor Cells to Arsenic Trioxide
2012
Previously, arsenic trioxide showed impressive regression rates of acute promyelocytic leukemia. Here, we investigated molecular determinants of sensitivity and resistance of cell lines of different tumor types towards arsenic trioxide. Arsenic trioxide was the most cytotoxic compound among 8 arsenicals investigated in the NCI cell line panel. We correlated transcriptome-wide microarray-based mRNA expression to the IC(50) values for arsenic trioxide by bioinformatic approaches (COMPARE and hierarchical cluster analyses, Ingenuity signaling pathway analysis). Among the identified pathways were signaling routes for p53, integrin-linked kinase, and actin cytoskeleton. Genes from these pathways…
Evidence of a New MoYpd1p Phosphotransferase Isoform in the Multistep Phosphorelay System of Magnaporthe oryzae
2021
Different external stimuli are perceived by multiple sensor histidine kinases and transmitted by phosphorylation via the phosphotransfer protein Ypd1p in the multistep phosphorelay system of the high osmolarity glycerol signaling pathway of filamentous fungi. How the signal propagation takes place is still not known in detail since multiple sensor histidine kinase genes in most filamentous fungi are coded in the genome, whereas only one gene for Ypd1p exists. That raises the hypothesis that various Ypd1p isoforms are produced from a single gene sequence, perhaps by alternative splicing, facilitating a higher variability in signal transduction. We found that the mRNA of MoYPD1 in the rice bl…
Competitive Industry Dynamics with Constant Costs
1998
This paper integrates investment and production decisions in a dynamic model of a competitive industry where producers, facing a technology involving fixed input–output coefficients, employ quantity adjustment rules. Whether complex dynamic price behaviour is consistent with producers breaking-even over time is explored. The proportion of costs which are sunk through investment is shown to have a potentially dramatic impact on the price dynamics. The implications of an alternative hypothesis— that producers ‘normally’ use their avail able capacities and only do otherwise if events are sufficiently dramatic—are explored
Activity against Microorganisms Affecting Cellulosic Objects of the Volatile Constituents of Leonotis nepetaefolia from Nicaragua
2014
The chemical composition of the essential oil from aerial parts of L. nepetaefolia (L.) R. Br. collected in Nicaragua was evaluated by GC and GC-MS. The main components were ( Z)-phytol (22.8%), caryophyllene oxide (18.9%) and hexahydrofarnesylacetone (9.0%). The antibacterial activity against several Gram + and Gram - bacteria, including Bacillus cereus and B. subtilis, both infesting historical cellulosic material, was also determined. B. cereus, B. subtilis and Staphylococcus epidermis were the most affected by the action of the oil.
Editorial: Calculation of Passenger Car Equivalents at Roundabouts
2021
Editorial on the Research Topic: Calculation of Passenger Car Equivalents at Roundabouts About this Research Topic: Calculation of Passenger Car Equivalents (PCEs) for heavy vehicles represents the starting point for the operational analysis of road facilities and other traffic management applications. PCEs are used to consider the presence of heavy vehicles in the traffic stream and are expressed as multiples of the effect of an average passenger car. Moreover, the highly curvilinear nature of the roundabout design, both in urban and rural environment, has significant effects on the paths that heavy vehicles would travel; as a consequence, the interaction between the physical and performan…
Pursaethosides A-E, triterpene saponins from Entada pursaetha.
2005
Five new triterpenoid saponins, pursaethosides A-E (1-5), were isolated from the n-BuOH extract of the seed kernels of Entada pursaetha along with the known phaseoloidin. The structures of 1-5 were elucidated mainly by spectroscopic data interpretation and chemical degradation. Pursaethosides C-E (3-5) possess as a common structural feature entagenic acid as aglycon, which is rare among triterpene saponins. Compounds 2-4 and phaesolidin were found to be not cytotoxic when tested against HCT 116 and HT-29 human colon cancer cells.
La "carcerazione degli infanti" nella lettura della Corte costituzionale
2015
Nota a Corte cost., 22 ottobre 2014, n. 239. Con la sentenza appena richiamata la Corte costituzionale dichiara l’illegittimità costituzionale dell’art. 4 bis, comma 1, della legge 26 luglio 1975, n. 354, in riferimento agli artt. 3, 29, 30 e 31 della Costituzione, nella parte in cui non esclude dal divieto di concessione dei benefici penitenziari la misura della detenzione domiciliare speciale, prevista dall’art. 47 quinquies della legge 26 luglio 1975, n. 354, e la misura della detenzione domiciliare, disciplinata dall’art. 47 ter, comma 1, lett. a) e b), della medesima legge.
Lo status dello straniero irregolare e le finalità rieducative dell'affidamento in prova al servizio sociale
2021
La disamina della decisione della Corte di legittimità, che ha ribaltato una decisione del Tribunale di Sorveglianza di Firenze di negazione di una misura alternativa in virtù del mero status di irregolare, è il pretesto per esaminare le basi legislative, la risposta giurisprudenziale le indicazioni dottrinare sul tema. Indicazioni tutte collimanti nel negare spazio ai trattamenti diseguali dei detenuti. Il percorso rieducativo sotteso all'opzione per le misure alternative, espressione dell'art. 27 Cost., non può essere pregiudicato dalle posizioni di svantaggio economico e sociale nel quale versano gli immigrati.
Pharmacophore Models Derived from Molecular Dynamics Simulations of Protein-Ligand Complexes: A Case Study
2018
A single, merged pharmacophore hypothesis is derived combining 2000 pharmacophore models obtained during a 20 ns molecular dynamics simulation of a protein-ligand complex with one pharmacophore model derived from the initial PDB structure. This merged pharmacophore model contains all features that are present during the simulation and statistical information about the dynamics of the pharmacophore features. Based on the dynamics of the pharmacophore features we derive two distinctive feature patterns resulting in two different pharmacophore models for the analyzed system – the first model consists of features that are obtained from the PDB structure and the second uses two features that ca…