Search results for "alzheimer"
showing 6 items of 706 documents
Estudio del mecanismo de reacción e inhibición de cisteína proteasas mediante métodos multiescala
2022
En esta tesis doctoral se realizaron estudios computacionales para las enzimas caspasa-1 y la 3CLpro del SARS-CoV-2. Estas enzimas pertenecen a la familia de las cisteína proteasas, las cuales hidrolizan sus respectivos sustratos rompiendo un enlace peptídico en particular. En esta reacción interviene una diada catalítica conformada por un par Cis-His. La caspasa-1 fue seleccionada debido a su importancia farmacológica en la enfermedad de Alzheimer, y la enzima 3CLpro del SARS-CoV-2 por estar involucrada en el proceso de replicación del virus responsable de la enfermedad del COVID-19. Para ambas se realizaron estudios que ayudaron a racionalizar el mecanismo de reacción con su sustrato natu…
The prolyl-isomerase PIN1 is essential for nuclear Lamin-B structure and function and protects heterochromatin under mechanical stress.
2021
Summary: Chromatin organization plays a crucial role in tissue homeostasis. Heterochromatin relaxation and consequent unscheduled mobilization of transposable elements (TEs) are emerging as key contributors of aging and aging-related pathologies, including Alzheimer’s disease (AD) and cancer. However, the mechanisms governing heterochromatin maintenance or its relaxation in pathological conditions remain poorly understood. Here we show that PIN1, the only phosphorylation-specific cis/trans prolyl isomerase, whose loss is associated with premature aging and AD, is essential to preserve heterochromatin. We demonstrate that this PIN1 function is conserved from Drosophila to humans and prevents…
Evaluation of the animal-assisted therapy in Alzheimer's disease
2017
Animal-assisted therapy sessions have been set up in a protected unit for patients with a dementia-related syndrome. The aim is to measure the effects of animal-assisted therapy on behavioural disorders in daily life and care. The results obtained provided some interesting areas to explore and recommendations with a view to optimising the implementation of such a system.
Lexical Substitution and Paraphasia in Advanced Dementia of the Alzheimer Type
2017
Abstract The paper presents the case study of lexical selection in Alzheimer-type dementia. Lexical substitutions in poem recitation and conversations of a Russian speaker, who suffered Alzheimer-type dementia, were analyzed on the background of the lexical retrieval and slip-of-the-tongue phenomena. The classification of the substitutions is worked out on the basis of the links between a target word and its substitutions. The current context plays an essential role as natural priming for a substitution in a poem recitation. Some words have predisposition to be lost; the units belong to the figurative language or to the category of infrequent lexemes. In conversation, the patient masked fai…
Elämän Don Quijotet : kokemuksia työikäisenä muistisairauteen sairastumisesta
2013
Tutkimukseni kuvaa työikäisenä etenevään muistisairauteen sairastuneiden ihmisten elä-mää. Tutkimukseni tavoitteena on tuottaa tietoa työikäisenä muistisairauteen sairastunei-den ihmisten arjesta sekä määrittää sairastuneiden sosiaalisen kuntoutuksen elementtejä. Tutkimuksen päämääränä on nostaa esille sairastuneiden oma ääni ja kokemuksellinen asiantuntijuus. Tutkimuksen metodologisena lähestymistapana on narratiivisuus. Aineiston keruumene-telmänä käytetään narratiivista haastattelua. Haastatteluihin osallistuu viisi Alzheimerin tautiin sairastunutta ihmistä. Tutkimuksen analyysimenetelmänä käytän tarinoiden eli nar-ratiivien analyysia. Analyysin perusteella sairastuminen muistisairauteen…
Il contributo sociale delle superfici vetrate.
2014
Oggi la domanda abitativa è cambiata, non solo negli aspetti quantitativi ma soprattutto nella dimensione qualitativa. Nel tempo, in relazione a fenomeni di carattere sociale ancor prima che economico, sono cambiate le categorie sociali più deboli, ora rappresentate soprattutto dagli anziani. Inoltre, in relazione all’innalzamento della soglia di mortalità, si assiste a un progressivo e costante aumento dei casi di demenza senile, un disturbo delle funzioni intellettive in precedenza acquisite quali la memoria a breve e lungo termine, il pensiero astratto, la capacità critica, il linguaggio e l’orientamento spazio temporale. L’ampia e crescente diffusione nella popolazione, la limitata e co…