Search results for "amer"

Rupture Force of Single Small Drug Molecule Binding a Split Aptamer

2012

Aptamers are specific oligonucleotides (DNA or RNA) which bind small inorganic or organic molecules, large proteins or cells. In particular, the high affinity of aptamers is expected to lead to a new class of therapeutic reagents. Thus the detection and characterization of binding strength of small molecules is important for drug and medical research. Atomic force spectroscopy (AFS) with a force resolution in the piconewton range is a valuable tool for studying interactions on a single molecular level. The detection of very small target molecules less than 500 Dalton is characterized by only a few hydrogen interactions between the aptamer and the target molecules. Thus tiny rupture forces w…

DNA Nanostructures in Cell Biology and Medicine

2017

Antibacterial drug release from a biphasic gel system: Mathematical modelling

2019

Bacterial infections represent an important drawback in the orthopaedic field, as they can develop either immediately after surgery procedures or after some years. Specifically, in case of implants, they are alleged to be troublesome as their elimination often compels a surgical removal of the infected implant. A possible solution strategy could involve a local coating of the implant by an antibacterial system, which requires to be easily applicable, biocompatible and able to provide the desired release kinetics for the selected antibacterial drug. Thus, this work focusses on a biphasic system made up by a thermo-reversible gel matrix (Poloxamer 407/water system) hosting a dispersed phase (…

High resolution 80Se(n,γ) cross section measurement at CERN n_TOF and development of the novel i-TED detection system

2022

El proceso (-s) de captura lenta de neutrones es responsable de la formación de la mitad de los elementos más pesados ​​que el hierro en el universo. A pesar de la larga escala de tiempo de este proceso, la larga vida media de algunos isótopos inestables a lo largo del flujo de reacción del proceso-s crea puntos de ramificación que conducen a una división de la ruta de la nucleosíntesis. 79Se (t1/2 = 3.27 x 10^5 y) representa uno de los núcleos ramificados-s más relevantes y debatidos por dos razones principales. Por un lado, la existencia de estados excitados de baja energía en el 79Se, cuya población puede variar con la temperatura del medio estelar, hace que el patrón de abundancia local…

Comparative Study of the Mechanical Unfolding Pathways of α- and β-Peptides

2015

Using molecular simulations, we analyze the unfolding pathways of various peptides. We compare the mechanical unfolding of a β-alanine's octamer (β-HAla8) and an α-alanine's decamer (α-Ala10). Using force-probe molecular-dynamics simulations, to induce unfolding, we show that the 3(14)-helix formed by β-HAla8 is mechanically more stable than the α-helix formed by α-Ala10, although both structures are stabilized by six hydrogen bonds. Additionally, computations of the potential of mean force validate this result and show that also the thermal stability of the 3(14)-helix is higher. It is demonstrated that β-HAla8 unfolds in a two-step fashion with a stable intermediate. This is contrasted wi…

Rey propietario o rey soberano

1994

La soberanía del rey en Ámerica.

Tratamiento jurídico de una enfermedad social. Los trastornos de la conducta alimentaria (TCA)

2018

The boundless increase of people suffering from an Eating Disorder (ED), makes necessary to develop measures related to other factors, in order to overcome the ones characterized of being strictly sanitary. The disease has become a social and cultural phenomenon. The exaltation of the cult to the body, with the stereotype of the extreme thinness linked with beauty and success is causing that, particularly young people, try to achieve an image which, in many cases, can jeopardize their health, that is the reason why the rearrangement of values has become an objective of paramount importance. Therefore, the fight against this social illness requires legal actions in order to prevent it from g…

Satire's corrective function: Jon Steward and post-modern, generative satire

2012

Masteroppgave i engelsk- Universitetet i Agder 2012

«I Do Not Understand the United States» Exploring why the gun issue is still so controversial, and why it is so difficult to enforce meaningful legis…

2020

Master´s thesis in English (EN501)

Investigating the Teaching and Learning of British and American Culture in Norwegian Upper Secondary School

2021

Master´s thesis in English (EN501) This thesis is an investigation of teachers’ influence on pupils related to cultural knowledge in upper secondary. A semi-structured interview with three teachers provide data that is compared with a survey questionnaire among their pupils. The main emphasis has been on British and American culture because of the standing in Norway. An essential factor is that the Norwegian curriculum is in the process of implementation. This fact created a need to consider changes to the curriculum because these changes may influence teaching and findings. Therefore the cultural theme’s position in the curriculum is presented with some historical developments. The researc…