Search results for "amer"

A framework for remission in SLE

2017

ObjectivesTreat-to-target recommendations have identified ‘remission’ as a target in systemic lupus erythematosus (SLE), but recognise that there is no universally accepted definition for this. Therefore, we initiated a process to achieve consensus on potential definitions for remission in SLE.MethodsAn international task force of 60 specialists and patient representatives participated in preparatory exercises, a face-to-face meeting and follow-up electronic voting. The level for agreement was set at 90%.ResultsThe task force agreed on eight key statements regarding remission in SLE and three principles to guide the further development of remission definitions:1. Definitions of remission wi…

Histone Code and Higher-Order Chromatin Folding: A Hypothesis

2016

AbstractHistone modifications alone or in combination are thought to modulate chromatin structure and function; a concept termed histone code. By combining evidence from several studies, we investigated if the histone code can play a role in higher-order folding of chromatin. Firstly using genomic data, we analyzed associations between histone modifications at the nucleosome level. We could dissect the composition of individual nucleosomes into five predicted clusters of histone modifications. Secondly, by assembling the raw reads of histone modifications at various length scales, we noticed that the histone mark relationships that exist at nucleosome level tend to be maintained at the high…

Genotypic analysis at multiple loci across Kaposi's sarcoma herpesvirus (KSHV) DNA molecules: clustering patterns, novel variants and chimerism

2001

Abstract Background: the genomes of human Kaposi's sarcoma-associated herpesvirus (KSHV) display several levels of DNA sequence heterogeneity and subgrouping that show distinctive clustering patterns in related human populations. The four major subtype patterns for the hypervariable ORF-K1 protein correlate closely with the principal diasporas resulting from the migration of modern humans out of East Africa and suggest that KSHV is an ancient human virus that is transmitted primarily in a familial fashion with consequent very low recombination rates. However, chimeric genomes have also been detected, especially with regard to the presence of P versus M alleles of the ORF-K15 gene. Objective…

Long-term impacts of tropical storms and earthquakes on human population growth in Haiti and Dominican Republic

2010

AbstractThe two Caribbean states, Haiti and the Dominican Republic, have experienced similar natural forces since the 18th century, including hurricanes and earthquakes. Although, both countries seem to be two of the most prone of all Latin American and Caribbean countries to natural hazard events, historically, Haiti tends to be more vulnerable to natural forces. The purpose of this article is to understand to what extent geohazards shape demographic changes. Research findings of this study show that neither atmospheric nor seismic hazards that directly hit the territory of Haiti have significant impacts on population densities and growth rates. Quantitative evidence is provided, that betw…

Miami, tourists, colonists and adventurers in the last boundary of Latin America

2012

Digital Zenith Cameras Results and Its Use in DFHRS v.4.3 Software for Quasi-Geoid Determination

2017

The design of digital zenith camera was started in 2010 by Institute of Geodesy and Geoinformatics. Since then the prototype of digital zenith camera has been developed. Now, after improvements of design and manufacturing of the second version, it has reached operational status. This paper describes the construction of zenith camera and features of its control software. The results of vertical deflections' measurements are discussed. At the moment measurements are done in Riga region and are used in DFHRS v.4.3 software in order to check and improve local quasigeoid model. It is a new method of quasigeoid model determination and has not been used in Latvia before. DFHRS (Digital Finite Elem…

Coherent South American Monsoon variability during the last millennium revealed through high‐resolution proxy records

2019

Shallow magma dynamics at open-vent volcanoes tracked by coupled thermal and SO2 observations

2022

Open-vent volcanic activity is typically sustained by ascent and degassing of shallow magma, in which the rate of magma supply to the upper feeding system largely exceeds the rate of magma eruption. Such unbalance between supplied (input) and erupted (output) magma rates is thought to result from steady, degassing-driven, convective magma overturning in a shallow conduit/feeding dyke. Here, we characterize shallow magma circulation at Stromboli volcano by combining independent observations of heat (Volcanic Radiative Power; via satellite images) and gas (SO2, via UV camera) output in a temporal interval (from August 1, 2018 to April 30, 2020) encompassing the summer 2019 effusive eruption a…

Diversity and Life Writing in the Transnational Classroom

2018

For this chapter, Alfred Hornung locates the origin of Germany’s diversity studies in the postwar era, during which Germany experienced gradual transculturation, especially due to the presence of African American soldiers, but also due to the appearance of American cultures in the media, the introduction of American studies in German universities, and the teaching of multi-ethnic authors in American literature courses. On the basis of international pedagogical experience, Hornung demonstrates that life writing lends itself particularly well to the representation and recognition of diversity and suggests how inclusion can be furthered. The focus of this chapter’s transnational classroom comp…

American Heart Association’s Cardiovascular Health Metrics and Risk of Cardiovascular Disease Mortality Among a Middle-aged Male Scandinavian Populat…

2019

Background: The burden of cardiovascular disease (CVD) prompted the American Heart Association to develop a cardiovascular health (CVH) metric as a measure to assess the cardiovascular status of the population. We aimed to assess the association between CVH scores and the risk of CVD mortality among a middle-aged Finnish population. Methods: We employed the prospective population-based Kuopio Ischemic Heart Disease cohort study comprising of middle-aged men (42–60 years). CVH scores were computed among 2607 participants at baseline and categorized as optimum (0–4), average (5–9), or inadequate (10–14) CVH. Multivariate cox regression models were used to estimate the hazard ratios (HR) and 9…