Search results for "aminosalicylic acid"

showing 3 items of 13 documents

Immunotherapeutic approaches to inflammatory bowel diseases

2001

For a long time corticosteroids, aminosalicylic acid preparations and antibiotics have represented the principal approaches in evidence-based drug therapy for chronic inflammatory bowel diseases (IBD), e.g., Crohn's disease (CD) and ulcerative colitis (UC), and are able to suppress disease activity in most cases. However, there are cases that do not respond to conventional drug therapy or remain dependent on high doses of steroids associated with severe side effects in the long run. It is generally accepted now that IBD has an immunological basis and results from a hyperresponsive state of the intestinal immune system. Although the primary etiological defect respectively immunogenic agent s…

PharmacologyAminosalicylic acidbusiness.industrymedicine.drug_classClinical BiochemistryAntibioticsDiseaseInflammatory Bowel Diseasesmedicine.diseaseInflammatory bowel diseaseUlcerative colitisdigestive system diseasesMicechemistry.chemical_compoundPharmacotherapyImmune systemchemistryDrug DiscoveryImmunologyEtiologyAnimalsHumansMedicineImmunotherapybusinessExpert Opinion on Biological Therapy
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Comparing medical treatments for Crohn’s disease

2013

The drugs available for inflammatory bowel disease are aminosalicylates, antibiotics, steroids, immunosuppressors and biologics. The effectiveness of these drugs has been evaluated in many randomized clinical trials, mainly versus placebo. Few studies have been conducted comparing the different drugs among themselves, owing to the methodological problems raised by comparative trials, such as sample size and blindness. This review focuses mainly on the randomized clinical trials that have compared different treatments. Of course comparisons are mainly between drugs used in a particular setting (mild, moderate and severe disease). However, on many occasions there is no homogeneity in these cl…

medicine.medical_specialtyPathologymedicine.drug_classAntibioticsAlternative medicineSevere diseasePlaceboInflammatory bowel diseaselaw.inventionBiological FactorsCrohn DiseaseRandomized controlled trialAdrenal Cortex HormoneslawInternal medicineAzathioprineIntestinal FistulaSecondary PreventionmedicineHumansBudesonideRandomized Controlled Trials as TopicCrohn's diseasebusiness.industryProbioticsHealth Policymedicine.diseaseAnti-Bacterial AgentsAminosalicylic AcidsMethotrexateSample size determinationbusinessJournal of Comparative Effectiveness Research
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Secretory effect of azodisalicylate (azodisal sodium) on the short circuited mucosa of the rat ileum in vitro.

1988

Azodisalicylate (ADS) is one of the newly developed substitutes of sulphasalazine consisting of two molecules of 5-amino-salicylic acid. Azodisalicylate caused diarrhoea in some patients, apparently caused by an antiabsorptive secretagogue action of this compound. The mechanism of this was studied in the short circuited isolated mucosa of the rat ileum. Mucosal addition of ADS increased the potential difference (PD) and short circuit current (Isc) at a concentration of 1.3.10(-4) mol/l (4 mg/dl) with maximal effects at 1.3.10(-3) mol/l (40 mg/dl). Epithelial resistance was only slightly decreased at the higher concentrations of 40 and 100 mg/dl. Serosal ADS had no effect on electrical param…

medicine.medical_specialtySodiumIndomethacinchemistry.chemical_elementIleumIn Vitro TechniquesBiologyEpitheliumMembrane PotentialsChloridesIntestinal mucosaFurosemideIleumInternal medicinemedicineAnimalsSecretionIntestinal MucosaTranscellularMembrane potentialSodiumElectric ConductivityGastroenterologyStimulation ChemicalRatsAminosalicylic AcidsEndocrinologymedicine.anatomical_structureMechanism of actionchemistrySecretagoguemedicine.symptomResearch ArticleGut
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