Search results for "ample"

THE RECOVERY-ELISA—A NOVEL ASSAY TECHNIQUE TO MONITOR THERAPY WITH HUMANIZED ANTIBODIES: THE EXAMPLE OF OMALIZUMAB

2013

The therapeutic use of antibodies has grown exponentially, providing new treatment options for various diseases. Monitoring treatment with therapeutic antibodies is a particular challenge because often the target antigen is no longer measurable or the results are unreliable. To overcome this problem, a recovery-ELISA was developed to quantify therapeutic antibody and antigen by a modification of the traditional sandwich immunoassay using omalizumab as an example. Standard serum samples were spiked with IgE and omalizumab in a certain concentration range to create standard curves. After incubation and washout procedures, the reaction was stopped and the plate read with bichromatic absorbance…

The application of phospholipid removal columns and ultra-high performance liquid chromatography-tandem quadrupole mass spectrometry for quantificati…

2016

In this study a robust and sensitive method based on a proposed sample purification procedure, using zirconia-coated Phree™ columns and analysis by ultra-high performance liquid chromatography with triple quadrupole tandem mass spectrometry are presented for the assessment of multi-class antibiotics in farmed fish species. The sample preparation procedure benefited from combined precipitation of proteins and selective removal of phospholipids by Phree™ columns, resulting in a high sensitivity of the method (LOQ 0.3-9mgkg(-1)). The in-house validation results (precision, repeatability, decision limit CCα, detection capability CCβ, etc.) indicate that the elaborated method is fully suitable f…

Corrigendum to “Assessing Decentering: Validation, Psychometric Properties, and Clinical Usefulness of the Experiences Questionnaire in a Spanish Sam…

2016

Prevalence of burnout in a sample of Brazilian teachers

2011

Background and Objectives: Burnout is a psychological response to chronic work-related stress of an interpersonal and emotional nature. Brazilian law have already contemplated burnout syndrome as a mental and behavioural disorder related to work. The aim of this study was to identify the prevalence of burnout in a sample of Brazilian teachers. Methods: The sample was composed of 714 teachers from 8 schools in Porto Alegre and its metropolitan area (Brazil). The levels of burnout were evaluated by the Spanish Burnout Inventory, educational version (SBI-Ed). In addition, Psychosomatic disorders were estimated by the UNIPSICO subscale. Results: The percentage of participants who indicated high…

VIII: Statistik in klinischen Publikationen: Checklisten für Autoren

2003

The "Material and Methods" section of clinical research papers should reference major aspects concerning statistical planning and evaluation of the study design and the resulting clinical data. Particular focus is laid on the listing of methods for description and significance evaluation of the trial data, as well as on design-associated study determinants (randomisation and masking strategy, response rate evaluation, primary endpoints, power and sample size determination, multiple testing, software and methods for statistical analysis). Suggestions for the minimum content to be mentioned in a trial publication are listed in author check lists and are illustrated by means of the study synop…

Fallzahlplanung bei ophthalmologischen Studien*

2000

An essential aspect in the cooperation of clinic and biometry consists in designing of studies, e.g. during the preparation of grant applications or for review by official drug surveillance institutions. A central aspect in study planning is the design-adequate and well-documented prediction of sample size, which should be recommended for any intended study. Based on several examples for sample size planning in study designs, which are of common relevance for ophthalmology, guidelines are derived to enable clinical researchers to perform sample size planning on their own. The latter can be based on the various available software packages for sample size prediction.

Managing the Buyer-Supplier Interactions

1999

On the basis of an empirical research on a sample of Italian plants, this study analyses the relationships between advanced buyer-supplier operational interaction practices (JIT, CE and TQM Approaches) and the basic options of the buyer’s purchasing strategy, such as: sources selection criteria, supply base reduction policies, long-term supply perspectives. In addition, the study compares these operational practices and purchasing policies in different performing plants.

Prevalence of Cognitive Frailty, Do Psychosocial-Related Factors Matter?

2020

Cognitive frailty (CF) is a topic of growing interest with implications for the study of preventive interventions in aging. Nevertheless, little research has been done to assess the influence of psychosocial variables on the risk of CF. Our objectives were to estimate the prevalence of CF in a Spanish sample and to explore the influence of psychosocial variables in this prevalence. Physical frailty and cognitive, functional, psychosocial, and socio-demographic aspects were assessed in a sample of 285 participants over 60 years. Univariate and multivariate logistic regression models were carried out. A prevalence of 21.8% (95% CI 17.4&ndash

A counterexample to Feit's Problem VIII on decomposition numbers

2016

We find a counterexample to Feit's Problem VIII on the bound of decomposition numbers. This also answers a question raised by T. Holm and W. Willems.

Poincaré Week in Göttingen, 22–28 April 1909

2018

When Paul Wolfskehl died in 1906, his will established a prize for the first mathematician who could supply a proof of Fermat’s Last Theorem, or give a counterexample refuting it. The interest from this prize money was later used to bring world-renowned mathematicians to Gottingen to deliver a series of lectures. Hilbert was apparently very pleased with this arrangement, and once jested that the only thing that kept him from proving Fermat’s famous conjecture was the thought of killing the goose that laid these golden eggs.