Search results for "anger"
showing 10 items of 929 documents
Echovirus 1 Entry into Polarized Caco-2 Cells Depends on Dynamin, Cholesterol, and Cellular Factors Associated with Macropinocytosis
2013
ABSTRACT Enteroviruses invade their hosts by crossing the intestinal epithelium. We have examined the mechanism by which echovirus 1 (EV1) enters polarized intestinal epithelial cells (Caco-2). Virus binds to VLA-2 on the apical cell surface and moves rapidly to early endosomes. Using inhibitory drugs, dominant negative mutants, and small interfering RNAs (siRNAs) to block specific endocytic pathways, we found that virus entry requires dynamin GTPase and membrane cholesterol but is independent of both clathrin- and caveolin-mediated endocytosis. Instead, infection requires factors commonly associated with macropinocytosis, including amiloride-sensitive Na + /H + exchange, protein kinase C, …
Incorporating spatial structure and stochasticity in endangered Bonelli’s eagle’s population models: implications for conservation and management
2008
Population models have played a chief role informing management decisions for the endangered Bonelli’s eagle (Aquila fasciata) in Spain. In this paper, we incorporate spatial structure and stochasticity in the construction of individual-based metapopulation models, and use these models to explore the effects of possible management actions on the persistence of the species in Spain. To build the models we used data on seven sub-populations that have experienced different trends in the last decades, and we introduced new estimates of pre-adult survival rate. The elasticity analysis of our models showed that when the interchange of individuals among sub-populations is taken into account, pre-a…
Quantifying the Indicator Power of an Indicator Species
2009
Biodiversity indicator species are needed for classifying biotopes and sites for conservation, and a number of methods have been developed for determining indicator species for this purpose. Nevertheless, in addition to site classification, there is sometimes a need to define an indicator species that indicates the occurrence of another species. For example, when a species of interest (target species) is difficult to detect or identify, a reliable indicator species can function as a tool that saves time and money. We derived a method that provides a quantitative measure of the indicator power (IP) of an indicator species for the target species or any species assemblage. We calculated the me…
Distribution, ecology and conservation survey on theCeltis tournefortiisubsp.aetnensis(Celtidaceae: Cannabaceae) populations in Sicily
2014
Results of research on the Celtis tournefortii subsp. aetnensis (Celtidaceae-Cannabaceae) populations in Sicily, based on the monitoring of the various nuclei distributed in the territory, are presented. In particular, two new important unpublished stations located in the southern part of the Sicani Mountains, widespread over an area of approximately 75 hectares, are reported. It is highlighted that the species, besides the lava flows of the western slope of Mount Etna (Catania province), is tied to conoids present in five other disjointed sub-ranges, often with fragmentary and relictual stations: (1) Nebrodi Mountains inland (Cesarò territory, Messina province); (2) Madonie Mountains inlan…
New paradigm of ICT productivity – Increasing role of un-captured GDP and growing anger of consumers
2015
Abstract The dramatic advancement of the Internet has led all nations to an information communication technology (ICT) driven development trajectory. This trajectory has resulted in bi-polarization between ICT growing economies and ICT advanced economies. While the former enjoys a virtuous cycle between ICT advancement and productivity increase, the later has fallen into a trap of a vicious cycle between ICT advancement and productivity decrease. This paper identifies that this trap can be attributed to the two-faced nature of ICT in which advancement of ICT contributes to price increases due to functionality development while dramatic advancement of the Internet has resulted in price decre…
Stock earnings and bond yields in the US 1871–2017 : The story of a changing relationship
2021
Abstract Using historical data spanning almost 150 years, we examine whether there is a long-run equilibrium relationship between the stock's earnings and bond yields. The novelty of our econometric methodology consists in using a vector error correction model where we allow multiple structural breaks in the equilibrium relationship. The results of our analysis suggest the existence of an equilibrium relationship over 1871–1932 and 1958–2017. On the two historical segments, our analysis finds that the stock's earnings yield followed the bond yield in both the short run and long run, but not the other way around. Perhaps the most important and surprising finding of our empirical study is tha…
Main driving factors of the interest rate-stock market Granger causality
2017
Abstract This paper investigates the causal relationship between changes in the 10-year Treasury bond yield and the S&P 500 stock return in the United Sates with emphasis on time variation, stress factors and smooth regime transition. First, the time-varying Granger causality test proposed by Lu et al. (2014) is applied. Then a two-regime multifactor smooth transition regression model with a single transition variable representing a wide range of macroeconomic and financial variables is estimated in order to identify the key explanatory factors governing the causal relationship. The results show a significant bidirectional causal relationship over most of the study period, mainly due to the…
Conservation of forest biodiversity using temporal conservation contracts
2012
Abstract Temporal conservation contracts are used to protect biodiversity in privately owned lands worldwide. We examine how stand characteristics and habitat requirements of target species affect the contract length in a boreal forest context. We develop an integrated optimization model and apply the model with data on endangered species occurring in spruce forests in Finland. The results suggest that a cost-effective conservation policy for protecting privately owned forest land involves both short- and long-term contracts between landowners and environmental agencies. The higher the conservation objective, the more intensively long-term contracts should be assigned. Managed stands should…
Time-varying causality between crude oil and stock markets: What can we learn from a multiscale perspective?
2017
This paper investigates the presence of time-varying causal linkages in mean and variance between oil price changes and stock returns for six major oil-importing countries (France, Germany, Italy, Spain, the UK and the US) in a multiscale framework that combines wavelet analysis and a modified version of the dynamic causality test of Lu, Hong, Wang, Lai, and Liu (2014). The results show significant bidirectional causal relations between oil and stock markets at the different time horizons for all countries. The causal links tend to be stronger at coarser scales and in periods of financial turmoil, mainly during the recent global financial and European sovereign debt crises. This evidence pr…
Cities, hinterlands and agglomeration shadows: Spatial developments in Finland during 1880–2004
2010
Abstract This paper analyzes long-term spatial developments in Finland by focusing on two predictions of the new economic geography (NEG) models: the increasing persistence of locational patterns and the rising dominance of growth centers. The empirical analysis is based on regional population data from 1880 to 2004. The results support the hypotheses. Evolutions in rank and rank-size distributions during the processes of industrialization and urbanization suggest increasing persistence of regional structures. The analysis of causal processes between population centers and their hinterlands shows that these regions grew hand-in-hand in the pre-war period, whereas agglomeration shadows start…