Search results for "anger"
showing 10 items of 929 documents
Tenapanor for the treatment of irritable bowel syndrome with constipation.
2020
Introduction: Irritable bowel syndrome with constipation is associated with higher rates of functional impairment, as compared to other subtypes of the syndrome. Conventional laxative-based pharmacologic therapy of IBS-C, which is mostly symptom-based, is often unsatisfactory. Tenapanor represents a first-in-class orally available inhibitor of NHE3, which is minimally absorbed in the GI tract, what constitutes a significant therapeutic benefit, as it may act on the drug target. Areas covered: Aim of this article is to sum up the evidences about pharmacodynamics and pharmacokinetics of tenapanor, focusing on animal models and in vitro studies, but also discuss clinical trials on tenapanor's …
Self-Distancing as a Strategy to Regulate Affect and Aggressive Behavior in Athletes: An Experimental Approach to Explore Emotion Regulation in the L…
2020
Self-regulation, especially the regulation of emotion, is an important component of athletic performance. In our study, we tested the effect of a self-distancing strategy on athletes’ performance in an aggression-inducing experimental task in the laboratory. To this end, we modified an established paradigm of interpersonal provocation [Taylor Aggression Paradigm (TAP)], which has the potential to complement field studies in order to increase our understanding of effective emotion regulation of athletes in critical situations in competitions. In our experimental setting, we first tested the applicability of the self-distancing perspective and the athletes’ ability to dynamically adapt beside…
Maturation of Epidermal Langerhans Cells In Vitro Is Accompanied by Downregulation of 4F2 (CD98) as Determined by Differential Display
1998
Following short-term culture, Langerhans cells mature morphologically and functionally into potent immunostimulatory cells. As regulation of gene expression accompanies this maturation process, it is likely that differentially expressed genes are involved in the maturation events. Using the recently described method of differential display, we generated cDNA expression patterns starting with mRNA of murine epidermal Langerhans cells isolated either directly (fLC) or following 3 d cultivation (cLC). Five hundred putative differentially expressed cDNA fragments were recovered from the gel. For a part of the fragments differential expression was confirmed by dot blot and Southern hybridization…
Physical Weaponization of a Smartphone by a Third Party
2022
In the literature and media, the treatment of the dangers and exposures posed by smartphones has generally focused on information security or privacy concerns. There have also been reports of fires, explosions, electric shocks, or loss of phone functionality due to faulty design or manufacture. This article provides an overview of acute physical and physiological dangers of smartphones that could be induced or triggered by a third party. It proposes a categorical discussion framework to describe and define the dangers in terms of attack vectors, effects on the smartphone, harms, and potential culprits/instigators. Counterfeit smartphones are themselves a significant potential threat in this…
Between-group competition and human cooperation.
2008
A distinctive feature of human behaviour is the widespread occurrence of cooperation among unrelated individuals. Explaining the maintenance of costly within-group cooperation is a challenge because the incentive to free ride on the efforts of other group members is expected to lead to decay of cooperation. However, the costs of cooperation can be diminished or overcome when there is competition at a higher level of organizational hierarchy. Here we show that competition between groups resolves the paradigmatic ‘public goods’ social dilemma and increases within-group cooperation and overall productivity. Further, group competition intensifies the moral emotions of anger and guilt associated…
Le recherche de l'identité à deux voix : Haroun et Meursault
2017
In his novel entitled The Meursault Investigation (Meursault, contre-enquête) Kamel Daoud shows human weakness and anger against the religion, the same as they are depicted in Albert Camus’s works. His character, Haroun, who is a brother of the Arab killed in The Stranger by Camus, is in the quest for his identity. Being traumatized by his mother’s hold over him, he learns French in order to be able to express his disappointment over the world and his country where he feels as a stranger.
Assessing Transfer Entropy in cardiovascular and respiratory time series: A VARFI approach
2021
In the study of complex biomedical systems represented by multivariate stochastic processes, such as the cardiovascular and respiratory systems, an issue of great relevance is the description of the system dynamics spanning multiple temporal scales. Recently, the quantification of multiscale complexity based on linear parametric models, incorporating autoregressive coefficients and fractional integration, encompassing short term dynamics and long-range correlations, was extended to multivariate time series. Within this Vector AutoRegressive Fractionally Integrated (VARFI) framework formalized for Gaussian processes, in this work we propose to estimate the Transfer Entropy, or equivalently G…
Bilevel heat exchanger network synthesis with an interactive multi-objective optimization method
2012
Abstract Heat exchanger network synthesis (HENS) has been an active research area for more than 40 years because well-designed heat exchanger networks enable heat recovery in process industries in an energy- and cost-efficient manner. Due to ever increasing global competition and need to decrease the harmful effects done on the environment, there still is a continuous need to improve the heat exchanger networks and their synthesizing methods. In this work we present a HENS method that combines an interactive multi-objective optimization method with a simultaneous bilevel HENS method, where the bilevel part of the method is based on grouping of process streams and building aggregate streams …
A comparison of the discrete and dimensional models of emotion in music
2010
The primary aim of the present study was to systematically compare perceived emotions in music using two different theoretical frameworks: the discrete emotion model, and the dimensional model of affect. A secondary aim was to introduce a new, improved set of stimuli for the study of music-mediated emotions. A large pilot study established a set of 110 film music excerpts, half were moderately and highly representative examples of five discrete emotions (anger, fear, sadness, happiness and tenderness), and the other half moderate and high examples of the six extremes of three bipolar dimensions (valence, energy arousal and tension arousal). These excerpts were rated in a listening experime…
Lentoasemien vaikutukset aluetalouteen : Granger-kausaalisuus analyysin sovellus
2011
Tässä tutkimuksessa on Granger-kausaalisuus analyysin avulla pyritty selvittämään alu-eellisten lentoasemien aluetalouksille mahdollistavia positiivisia talousvaikutuksia. Len-toasemien taloudellisia vaikutuksia on tutkittu paljon viime vuosikymmeninä. Samaan aikaan alueellisten lentoasemien aluetalouksille aiheuttavan taloudellisen hyödyn tutki-minen on jäänyt selvästi vähemmälle huomiolle. Pienet alueelliset lentoasemat ovat tär-keässä roolissa osana kaupunkien, maakuntien ja valtioiden liikennejärjestelmää. Niiden elinvoimaisuuden ajatellaan usein olevan suuresti riippuvainen alueen talouselämän hy-vinvoinnista. Tutkimuksen empiriaosuudessa on perehdytty suomalaisten alueellisten lentoas…