Search results for "anti-miR-182"
showing 2 items of 2 documents
Effects of anti-miR-182 on Thrombospondin-1 expression in human colon cancer cells
2012
ABSTRACT Background: MicroRNAs are small non-coding RNAs that regulate the expression of different genes, involved in cancer progression, angiogenesis and metastasis. Bio-informatic statistical analysis indicated that miR-182, over-expressed in colorectal cancer (CRC), has like predictive target Thrombospondin-1 (TSP-1), a protein inversely correlated with tumor vascularity and metastasis that results downregulated in different types of cancer including CRC. Early Growth Response 1 (Erg-1) and Specificity Protein 1 (Sp-1) are transcriptional factors that bind consensus sequence on TSP-1 gene promoter and are putative target of miR-96/182/183 cluster. MiR-182 could target SMAD4, which expres…
Effects of anti-miR-182 on TSP-1 expression in human colon cancer cells: there is a sense in antisense?
2013
Abstract: Objective: miRNAs are attractive molecules for cancer treatment, including colon rectal cancer (CRC). We investigate on the molecular mechanism by which miR-182 could regulate thrombospondin-1 (TSP-1) expression, a protein down-regulated in CRC and inversely correlated with tumor vascularity and metastasis. Background: MicroRNAs are small non-coding RNAs that regulate the expression of different genes, involved in cancer progression, angiogenesis and metastasis. miR-182, over-expressed in colorectal cancer (CRC), has like predictive target thrombospondin-1 (TSP-1), a protein inversely correlated with tumor vascularity and metastasis that results downregulated in different types of…