Search results for "anti-tuberculosis"
showing 3 items of 3 documents
The zebrafish embryo as an in vivo model for screening nanoparticle-formulated lipophilic anti-tuberculosis compounds.
2021
ABSTRACT With the increasing emergence of drug-resistant Mycobacterium tuberculosis strains, new and effective antibiotics against tuberculosis (TB) are urgently needed. However, the high frequency of poorly water-soluble compounds among hits in high-throughput drug screening campaigns is a major obstacle in drug discovery. Moreover, in vivo testing using conventional animal TB models, such as mice, is time consuming and costly, and represents a major bottleneck in lead compound discovery and development. Here, we report the use of the zebrafish embryo TB model for evaluating the in vivo toxicity and efficacy of five poorly water-soluble nitronaphthofuran derivatives, which were recently id…
IL-12 Expands and Differentiates Human Vγ2Vδ2 T Effector Cells Producing Antimicrobial Cytokines and Inhibiting Intracellular Mycobacterial Growth
2019
While IL-12 plays a key role in differentiation of protective CD4+ Th1 response, little is known about mechanisms whereby IL-12 differentiates other T-cell populations. Published studies suggest that predominant Vγ2Vδ2 T cells in humans/nonhuman primates (NHP) are a fast-acting T-cell subset, with capacities to rapidly expand and produce Th1 and cytotoxic cytokines in response to phosphoantigen (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP) produced by Mycobacterium tuberculosis (Mtb) or others. However, whether IL-12 signaling pathway mediates fast-acting and Th1 or anti-microbial features of Vγ2Vδ2 T cells remains poorly defined. Here, we show that IL-12, but not other IL-12 fami…
Los saberes en torno a la tuberculosis en Valencia a través de la prensa médica (1882-1914)
2011
Para la realización de este trabajo se ha partido del interés que tiene estudiar la literatura científica que a finales del siglo XIX y principios del XX dedicó una sociedad como la valenciana al tema de la tuberculosis, de primera importancia no solo en la realidad epidemiológica de la época, sino también para la constitución de la ciencia y las prácticas médicas contemporáneas. Se ha abordado el estudio de los saberes en torno a la tuberculosis en Valencia a través de las revistas médicas publicadas en ella entre 1882 y 1914, periodo en el que se descubrió el origen microbiano de la enfermedad y se desarrollaron nuevas técnicas diagnósticas, preventivas y curativas de la infección tubercu…