Search results for "antibiotic"
showing 7 items of 807 documents
Thiazole Analogues of the Marine Alkaloid Nortopsentin as Inhibitors of Bacterial Biofilm Formation
2020
Anti-virulence strategy is currently considered a promising approach to overcome the global threat of the antibiotic resistance. Among different bacterial virulence factors, the biofilm formation is recognized as one of the most relevant. Considering the high and growing percentage of multi-drug resistant infections that are biofilm-mediated, new therapeutic agents capable of counteracting the formation of biofilms are urgently required. In this scenario, a new series of 18 thiazole derivatives was efficiently synthesized and evaluated for its ability to inhibit biofilm formation against the Gram-positive bacterial reference strains Staphylococcus aureus ATCC 25923 and S. aureus ATCC 6538 a…
Double copies of blaKPC-3::Tn4401a on an IncX3 plasmid in Klebsiella pneumoniae successful clone ST512 from Italy
2015
ABSTRACT A carbapenem-resistant sequence type 512 (ST512) Klebsiella pneumoniae carbapenemase 3 (KPC-3)-producing K. pneumoniae strain showing a novel variant plasmid content was isolated in Palermo, Italy, in 2014. ST512 is a worldwide successful clone associated with the spread of bla KPC genes located on the IncFIIk pKpQIL plasmid. In our ST512 strain, the bla KPC-3 gene was unusually located on an IncX3 plasmid, whose complete sequence was determined. Two copies of bla KPC-3 ::Tn 4401a caused by intramolecular transposition events were detected in the plasmid.
Black Queen Evolution and Trophic Interactions Determine Plasmid Survival after the Disruption of the Conjugation Network
2018
Bacterial antibiotic resistance is often a part of mobile genetic elements that move from one bacterium to another. By interfering with the horizontal movement and the maintenance of these elements, it is possible to remove the resistance from the population. Here, we show that a so-called plasmid-dependent bacteriophage causes the initially resistant bacterial population to become susceptible to antibiotics. However, this effect is efficiently countered when the system also contains a predator that feeds on bacteria. Moreover, when the environment contains antibiotics, the survival of resistance is dependent on the resistance mechanism. When bacteria can help their contemporaries to degrad…
Environmental remediation using nanomaterial as adsorbents for emerging micropollutants
2023
Water shortage and scarcity are issues of global concern. Water pollution caused by organic micropollutants further aggravates the problem, by rendering an already scarce resource unfit for human consumption. The existing conventional wastewater treatment methods and infrastructure were not designed to eliminate micropollutants. Therefore, their inefficiencies call for modern methods for removing emerging micropollutant residues such as Active Pharmaceutical Ingredients (APIs), Endocrine Disrupting Compounds (EDCs), personal care products and pesticides. The use of nanomaterials, for the abatement of micropollutants in water is gaining traction in recent years, due to the abundance of susta…
Systematic Comparison of Epidemic and Non-Epidemic Carbapenem Resistant Klebsiella pneumoniae Strains
2021
Over the past few decades, extensively drug resistant (XDR) resistant Klebsiella pneumoniae has become a notable burden to healthcare all over the world. Especially carbapenemase-producing strains are problematic due to their capability to withstand even last resort antibiotics. Some sequence types (STs) of K. pneumoniae are significantly more prevalent in hospital settings in comparison to other equally resistant strains. This provokes the question whether or not there are phenotypic characteristics that may render certain K. pneumoniae more suitable for epidemic dispersal between patients, hospitals, and different environments. In this study, we selected seven epidemic and non-epidemic ca…
Multispecies coinfections and presence of antibiotics shape resistance and fitness costs in a pathogenic bacterium
2023
Increasing antimicrobial resistance (AMR) poses a challenge for treatment of bacterial diseases. In real life, bacterial infections are typically embedded within complex multispecies communities and influenced by the environment, which can shape costs and benefits of AMR. However, knowledge of such interactions and their implications for AMR in vivo is limited. To address this knowledge gap, we investigated fitness-related traits of a pathogenic bacterium (Flavobacterium columnare) in its fish host, capturing the effects of bacterial antibiotic resistance, coinfections between bacterial strains and metazoan parasites (fluke Diplostomum pseudospathaceum) and antibiotic exposure. We quantifie…
Projekty citizen science jako metoda wzmocnienia świadomości społecznej o problemie antybiotykooporności
2023
Problem antybiotykooporności jest według WHO jednym z najbardziej donośnych zagrożeń XXI wieku. Z roku na rok umiera coraz więcej osób na skutek zakażenia bakterią, która jest oporna na znane antybiotyki. Aby zapobiegać rozwojowi antybiotykooporności konieczny jest wzrost świadomości społecznej o niekorzystnych skutkach nadużywania i niewłaściwego stosowania antybiotyków. W tym celu prowadzone są liczne kampanie i akcje społeczne. Aby dotrzeć z tymi informacjami także do młodzieży realizowane są projekty citizen science, w które zaangażowani są studenci i uczniowie. W artykule przedstawimy cele i zakres projektów citizen science oraz service learning podejmowanych w celu edukacji społeczeńs…