Search results for "anus"
showing 10 items of 841 documents
Una Praeparatio ad Missam Pontificalem miniata da Jacopo Ravaldi per l’arcivescovo Ausiàs Despuig ritrovata a Monreale. Prime considerazioni
2022
Il saggio presenta alla comunità scientifica un manoscritto miniato quattrocentesco del Tesoro della Cattedrale di Monreale già noto ad Angela Daneu Lattanzi e recentemente ritrovato, attribuendone la committenza al cardinale Ausias Despuig e la paternità al miniatore francese Jacopo Ravaldi attivo a Roma. The essay presents to the scholarly community a 15th-century illuminated manuscript from the Treasury of the Cathedral of Monreale already known to Angela Daneu Lattanzi and recently rediscovered, attributing its commission to Cardinal Ausias Despuig and its authorship to the French illuminator Jacopo Ravaldi active in Rome.
Philosophical thought of the School of the Sextii
2014
Around the first half century B.C. the first Roman school of philosophy arose, which was called School of Sextii. The known members of the School were: Quintus Sextius the Elder, founding father of the School, Sextius Niger, Quintus' son, who became scholarch of the School after his father's death, Sotion, Papirius Fabianus (both teachers of Seneca the Younger), Crassicius Pasicles, a grammarian, and Celsius Cornelius, an expert doctor. The School followed the footsteps of the Hellenistic schools, and similar to these, the pursuit of happiness was its purpose. The school of the Sextii had taken to heart that part of the philosophy called physical, characterizing itself mainly as a philosoph…
Interspecific hybridisation among diverse Saccharomyces species: A combined biotechnological solution for low-temperature and nitrogen-limited wine f…
2019
Lack of the prezygotic barrier in the Saccharomyces genus facilitates the construction of artificial interspecific hybrids among different Saccharomyces species. Hybrids that maintain the interesting features of parental strains have been applied in industry for many beneficial purposes. Two of the most important problems faced by wine makers is nitrogen deficiency in grape must and low-temperature fermentation. In our study, hybrids were constructed by using selected low nitrogen-demanding cryotolerant S. eubayanus, S. uvarum strains and S. cerevisiae. The fermentation capacity of the hybrid strains was tested under four conditions by combining two temperatures, 12 °C and 28 °C, and two ni…
Suppressor of cytokine signaling 3 sensitizes anaplastic thyroid cancer to standard chemotherapy
2009
We previously showed that cancer cells from papillary, follicular, and anaplastic thyroid carcinomas produce interleukin-4 and interleukin-10, which counteract the cytotoxic activity of conventional chemotherapy through the up-regulation of antiapoptotic molecules. Here, we identify Janus kinase/signal transducers and activators of transcription (STAT) and phosphatidyl inositol 3-kinase (PI3K)/AKT as the down-stream pathways through which these cytokines confer resistance to cell death in thyroid cancer. We found that the absence of suppressors of cytokine signaling (SOCS) molecules allows the propagation of the survival signaling. Exogenous expression of SOCS1, SOCS3, and SOCS5 in the high…
Parthenolide sensitizes hepatocellular carcinoma cells to trail by inducing the expression of death receptors through inhibition of STAT3 activation
2011
This article shows that HepG2, Hep3B, and SK-Hep1 cells, three lines of human hepatocellular carcinoma (HCC) cells, are resistant to apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Parthenolide, a sesquiterpene lactone found in European feverfew, has been shown to exert both anti-inflammatory and anti-cancer activities. This article demonstrates that co-treatment with parthenolide and TRAIL-induced apoptosis with synergistic interactions in the three lines of HCC cells. In order to explain these effects we ascertained that parthenolide increased either at protein or mRNA level the total content of death receptors TRAIL-R1 and -R2 as well as their surfac…
Nitric Oxide-Releasing Drug Glyceryl Trinitrate Targets JAK2/STAT3 Signaling, Migration and Invasion of Triple-Negative Breast Cancer Cells
2021
Triple-negative breast cancer (TNBC) is a highly aggressive disease with invasive and metastasizing properties associated with a poor prognosis. The STAT3 signaling pathway has shown a pivotal role in cancer cell migration, invasion, metastasis and drug resistance of TNBC cells. IL-6 is a main upstream activator of the JAK2/STAT3 pathway. In the present study we examined the impact of the NO-donor glyceryl trinitrate (GTN) on the activation of the JAK2/STAT3 signaling pathway and subsequent migration, invasion and metastasis ability of TNBC cells through in vitro and in vivo experiments. We used a subtoxic dose of carboplatin and/or recombinant IL-6 to activate the JAK2/STAT3 signaling path…
Difficulties detecting miRNA-203 in human whole saliva by the use of PCR
2014
Objectives: Oral Lichen Planus (OLP) is a chronic disease of the oral mucosa, and according to the WHO also a pre malignant condition. Micro-RNAs are short non coding RNAs capable of regulating mRNA expression. MiRNA:scan be detected in tissue, blood and human whole saliva (HWS) and recently we have shown miR-203 to be up-regulated in tissue from OLP lesions. Study Design: In order to see whether mRNA as well as miR-203 could be detected also in HWS, saliva from healthy controls and patients with OLP were analysed using two different PCR methods. Results: Results showed low mRNA and miRNA levels in general in HWS samples, making it hard to generate conclusive results. Conclusions: In order …
Salivary apoptotic cells in oral (pre-) cancer as a potential diagnostic means
2015
Background: Apoptosis is a genetically programmed form of cell death which is indispensable for development and homeostasis of multi-cellular organism. Objectives: The aim of this study was to find out the salivary apoptotic cells in oral precancerous and cancerous patients and furthermore to observe the potential diagnostic value of salivary apoptotic cells in detection of oral pre-cancer and cancer. Materials and Methods: Unsimulated saliva was collected from a group of 103 subjects diagnosed with oral (pre-) cancer and a control group of 30 healthy age- and gender-matched individuals. The test group diagnosed with (pre-) cancer was further subdivided in 4 lesion groups oral squamous cell…
Platanus orientalis L. In Rossi G., Foggi B., Gennai M., Gargano D., Montagnani C., Orsenigo S., Pedrini S.: Schede per una Lista Rossa della Flora v…
2012
El sermón "fiet unum ouile et unus pastor" (Io 10, 16) de san Vicente Ferrer en Caspe
2013
El diario de sesiones del Compromiso de Caspe indica que el Maestro Vicente Ferrer el domingo 17 de abril de 1412 pronunció un sermón poco conocido sobre el tema bíblico 'Fiet unum ouile et unus pastor' (Io 10, 16). Diversos manuscritos e impresos transmiten diferentes estados de su redacción. En este trabajo además de contextualizar en el mencionado Compromiso este sermón, se edita según su tradición textual más genuina.