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Determination of kinetic parameters of redox reactions using CE‐ICP‐MS: A case study for the reduction of Np(V) by hydroxylamine hydrochloride
2018
The rate constants k of the reduction of 5 × 10-5 M Np(V) to Np(IV) by hydroxylamine hydrochloride (HAHCl) in 1 M HCl have been determined by CE-ICP-MS in the temperature range of ϑ = 30-70°C and with varying concentrations of HAHCl from 1 to 7.2 M. The reaction was found to have (pseudo)first order kinetics with respect to HAHCl. The experimental results for k ranged from 0.0029(1) min-1 (ϑ = 40°C, c(HAHCl) = 3 M) to 0.039(7) min-1 (ϑ = 60°C, c(HAHCl) = 7.2 M). The activation energy of the reaction was determined as EA = (72 ± 10) kJ/mol. These results and a comparison with literature data show that the coupling of CE to ICP-MS provides a powerful analytical tool for the investigation of…
Chiral separation of oxprenolol by affinity electrokinetic chromatography-partial filling technique using human serum albumin as chiral selector
2005
The intrinsic characteristics of capillary electrophoresis have made this technique a powerful tool in the chiral separation field. The present paper deals with the enantiomeric separation of oxprenolol enantiomers by affinity electrokinetic chromatography-partial filling technique using human serum albumin (HSA) as chiral selector. Several experimental conditions and variables affecting the separation such as pH, HSA concentration and plug length, background electrolyte concentration, temperature and voltage were studied. Baseline separation of oxprenolol enantiomers was obtained in less than 8 min under the following selected conditions: electrophoretic buffer composed of 50 mM Tris-(hydr…
Evaluation of enantioselective binding of fluoxetine to human serum albumin by ultrafiltration and CE - Experimental design and quality considerations
2012
Several pharmacokinetic processes are affected by enantioselectivity (ES). At the level of distribution, protein binding (PB) is one of the most important. The enantioselective binding of fluoxetine (FLX) to HSA has been evaluated in this work by ultrafiltration of FLX–HSA mixtures and chiral analysis of unbound fractions by EKC-CD. PB, affinity constants (K) and ES were obtained for both enantiomers of FLX. In order to improve the consistency of the estimations, the evaluation of affinity constants of each enantiomer was performed using two designs, one keeping constant the total concentration of protein and varying the total concentration of the enantiomers, and the other in the opposite …
Evaluation of enantioselective binding of propanocaine to human serum albumin by ultrafiltration and electrokinetic chromatography under intermediate…
2011
Abstract Stereoselectivity in protein binding can have a significant effect on the pharmacokinetic and pharmacodynamic properties of chiral drugs. In this paper, the enantioselective binding of propanocaine (PRO) enantiomers to human serum albumin (HSA), the most relevant plasmatic protein in view of stereoselectivity, has been evaluated by incubation and ultrafiltration of racemic PRO–HSA mixtures and chiral analysis of the bound and unbound fractions by electrokinetic chromatography using HSA as chiral selector. Experimental conditions for the separation of PRO enantiomers using HSA as chiral selector and electrokinetic chromatography have been optimised. Affinity constants and protein bi…
Does shape matter? preferences for a female therapist's figure among patients with eating disorders
2007
Abstract Although the female therapist's figure has been a topic of discussion with regard to psychotherapy for eating disorders, it has not yet been addressed empirically. In this study, participants with eating disorders (n =34) and a control group of participants with anxiety disorders (n =30) were asked to indicate how important the therapist's figure is to them and what shape they would prefer a therapist to have. The therapist's figure was more important among participants with eating disorders than among those with anxiety disorders. Participants in both groups favored a therapist with an average figure. Within both groups, participants preferred their therapist to have a shape simil…
Conscious and unconscious identification of female anorectic patients in in-patient psychotherapy
2009
Women are up to ten times more likely to develop anorexia nervosa (AN) than men. Psychoanalytic explanations of this disparity generally emphasize female identification problems due to unresolved conflicts with maternal representations. Based on clinical observation, we identify a subtype of AN patients characterized, first, by consistent idealization of the father who needs the patient for the fulfilment of his own narcissistic needs and, second, by the patient's need to be idealized by the father due to suffering in connection with early emotional malnutrition on the part of the mother. To illustrate this hypothesis, we present the case of a well-educated young woman displaying unconsciou…
Virtual reality in the treatment of claustrophobic fear: A controlled, multiple-baseline design
2000
The aim of this study was to determine the effectiveness of virtual reality (VR) exposure in the treatment of claustrophobic fear. We evaluated the intervention following a controlled, multiple-baseline design across 4 participants with claustrophobic fear who sought psychological help in our anxiety disorders clinic. The treatment consisted of 8 individual VR graded exposure sessions. Data were obtained at pretreatment, posttreatment, and 3-month follow-up on several clinical measures: Behavioral Avoidance Test, Self-Efficacy Toward Closed Spaces, Problem-Related Impairment Questionnaire, Beck Depression Inventory (Beck, 1978), and Anxiety Sensitivity Index (Peterson & Reiss, 1992). Result…
Therapeutic Alliance: What Can be Learned from Case Studies?
1992
Two different video-taped short-term psychotherapies were rated on therapeutic alliance for 27 sessions. The ratings were based on two methods: the Penn Helping Alliance Scales (Penn-HAS) and the Therapeutic Alliance Rating Scale (TARS). Both scales provide separate scores for the therapist and the patient. After checking the reliabilities of the ratings, the strength and course of the alliance formation are compared within and across therapies. Furthermore it was hypothesized that the alliance is structured differently in the two therapies. This hypothesis is tested by making content-specific item comparisons across the therapies for the Penn-HAS and by a comparison of the factor structure…
The assimilation of problematic experiences in linguistic therapy of evaluation: How did maría assimilate the experience of dizziness?
2006
Abstract The assimilation model proposes eight stages through which patients with problematic experiences pass during assimilation, ranging from suppression or dissociation to mastery. These are summarized in the Assimilation of Problematic Experiences Scale (APES). The assimilation model and the APES have been developed through intensive qualitative study of significant therapeutic events. This article describes the process of assimilation of the problematic experiences of dizziness in a patient, Maria, treated with linguistic therapy of evaluation. All treatment sessions were analyzed with the goals of describing the process of assimilation and connecting this process with the therapeutic…
Die Erfassung allgemeiner Wirkfaktoren in der Psychotherapie
2020
Zusammenfassung: Theoretischer Hintergrund. Stundenbögen dienen einer standardisierten Prozessdiagnostik und Verlaufsdokumentation. Bislang vorliegende Instrumente werden in der Praxis häufig nicht eingesetzt, haben einen eingeschränkten Geltungsraum oder weisen psychometrische Schwächen auf. Der Mainzer Stundenbeurteilungsbogen (MSB) versucht allgemeine Wirkfaktoren ökonomisch zu erfassen. Ziel der Studie ist die Untersuchung des MSB in der Patienten- und Therapeutenversion hinsichtlich Faktorenstruktur, Itemstatistiken und Gütekriterien. Methoden: Der MSB wurde zu zwei Zeitpunkten (5. und 20. therapeutische Sitzung) in einer Stichprobe ambulanter Psychotherapiepatienten ( N = 4.608, N = …