Search results for "api"

[Pharmacogenomics of antiretrovirals].

2008

HIV infection is a serious but treatable disease, yet current treatment is limited by development of resistance and high rates of adverse drug reactions. Antiretroviral therapy is especially suitable for pharmacogenomic investigation as both drug exposure and treatment response can be reliably measured. Increasing knowledge about genes implicated in pharmacokinetics, mode of action, efficacy, and toxicity of drugs has already provided relevant results for clinical practice, for example: The strong association of the abacavir hypersensitivity reaction with HLA-B*5701 permits testing patients for the allele, and if present avoiding the drug and therefore preventing the reaction. Persons with …

Efavirenz induces interactions between leucocytes and endothelium through the activation of Mac-1 and gp150,95

2013

The potential cardiovascular (CV) toxicity associated with combined antiretroviral therapy (cART) has been attributed mainly to the nucleoside reverse transcriptase inhibitors abacavir and didanosine. However, the other two components of cART--non-nucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors (PIs)--may also be implicated, either directly or by influencing the action of the other drugs. This study evaluates the acute direct effects of the NNRTIs efavirenz and nevirapine and one of the most widely employed PIs, lopinavir, on leucocyte-endothelium interactions, a hallmark of CV disease.Drugs were analysed in vitro in human cells (interactions of peripheral blood…

Cyclotron –PET/CT: radioprotection aspects, check and tests

2009

<strong>New record and redescription of the monotypic genus <em>Comefulvius</em> Carvalho & Carpintero, 1985 (Hemiptera: He…

2014

Comefulvius chingonus Carvalho & Carpintero, the only representative of the genus Comefulvius, previously known only from Cordoba Province, Argentina, is recorded from Ecuador. Redescription of Comefulvius is given along with color photographs of the adult and illustrations of the male genitalia.

Review of the genus Valdasus Stål, 1860 (Heteroptera, Miridae, Cylapinae), with descriptions of four new species from Brazil, Ecuador and French Guia…

2020

The genus Valdasus Stål, 1860 is reviewed. Four species are described as new: Valdasus favrei n. sp., V. ferrerai n. sp., V. flavinotum n. sp., and V. henryi n. sp. V. erebeus Distant, 1883 and V. stygius Distant, 1883 are transferred again to Valdasus (original combination reestablished) from Peltidocylapus Poppius and they are redescribed along with the type species V. schoenherri Stål, 1860. Presence of V. bolivianus in Argentina is challenged after new analysis of female specimen mentioned in literature. 

The effect of kinetin on the photosynthetic apparatus of Sinapis alba

1980

The influence of kinetin during the development of primary leaves of Sinapis alba was investigated. Kinetin treatment (6 ppm) induced an increase of dry weight, of soluble reducing sugars, soluble protein, chlorophylls, carotenoids and cytochrome f; a higher ratio of chlorophyll a to chlorophyll b, higher rates of CO2 fixation per fresh weight and higher activity of nitrite reductase, were also found. These effects are comparable with strong and blue light adaptations. On the other hand, the Hill activity with ferricyanide as the electron acceptor, the rates of CO2 fixation per chlorophyll, the ratios of chlorophyll to cytochrome f and of protein to chlorophyll did not change. Therefore we …

The effect of indole-3-acetic-acid on the photosynthetic apparatus of Sinapis alba

1980

The influence of indole-3-acetic-acid (IAA) during the development of primary leaves of Sinapis alba was studied. IAA treatment (4 ppm ≈ 22.8 μM) caused a decrease of dry weight, soluble reducing sugars, soluble protein, chlorophylls, carotenoids and cytochrome f; it also caused a lower ratio of protein to chlorophyll, a lower ratio of chlorophyll a to chlorophyll b and a higher ratio of chlorophyll per cytochrome f. Furthermore, IAA treatment induced a significantly lower rate of CO2 fixation and a depressed nitrite reductase activity. Similar effects could also be observed in adaptation reactions brought about by red light and low-light (or shade) conditions.

Measurements of cytochrome f and P-700 in intact leaves of Sinapis alba grown under high-light and low-light conditions

1978

The oxidation and reduction of cytochrome f and P-700 is measured spectrophotometrically in leaves of low-light and high-light plants. After illumination with red light, an induction phenomenon for cytochrome f oxidation is observed which indicates a regulation of photosystem I activity through energy distribution between the pigment systems by the energy state of the membrane. After far-red excitation the reduction of cytochrome f in the dark is much slower in low-light leaves. This shows that cyclic electron transport is not improved in low-light plants under these conditions. P-700 is oxidized on excitation with far-red light. However, with high intensities of far-red light, P-700 is par…

Studies on the Content of P 700 and Cytochromes in Sinapis alba During Growth Under Two Different Light Intensities

1975

Sinapis alba was grown under two extremely different light intensities. We obtained two different modifications which hold several physiological and biochemical characteristics comparable to the relations in light- and shade plants. In the strong light the maximum rate of CO2-uptake increases within five days to a three-fold rate. At the same time the content of several redox systems of photosynthetic electron transport increases while the content of P 700 remains equivalent in both types of plants. In the high-light plants we find a ratio P 700: Cytochrome f of 1 but a ratio of 3 in the low-light plants. These ratios could be probably essential features of various sun- and rainforest speci…

The Effect of Blue and Red Light on the Content of Chlorophyll, Cytochrome f, Soluble Reducing Sugars, Soluble Proteins and the Nitrate Reductase Act…

1980

The photosynthetic characteristics of many species of plants are influenced by the light intensity under which the plant is grown. This is shown by the light saturation curves for CO2 uptake. Both the light intensity required for saturation and the light-saturated rate of CO2 uptake increase with the light intensity under which the plant is grown. Photosynthetic adaptation to different light levels involves balanced changes of many leaf factors. Low-light and high-light plants differ in a number of component steps of photosynthesis as well as in the structure and composition of the photosynthetic apparatus and in the leaf anatomy (see reviews by Boardman 1977; Wild 1979).