Search results for "application"
showing 10 items of 5559 documents
Focus on the Small GTPase Rab1: A Key Player in the Pathogenesis of Parkinson’s Disease
2021
Parkinson’s disease (PD) is the second most frequent neurodegenerative disease. It is characterized by the loss of dopaminergic neurons in the substantia nigra and the formation of large aggregates in the survival neurons called Lewy bodies, which mainly contain α-synuclein (α-syn). The cause of cell death is not known but could be due to mitochondrial dysfunction, protein homeostasis failure, and alterations in the secretory/endolysosomal/autophagic pathways. Survival nigral neurons overexpress the small GTPase Rab1. This protein is considered a housekeeping Rab that is necessary to support the secretory pathway, the maintenance of the Golgi complex structure, and the regulation of macroau…
Introducing evidence-based practices to manage problem behaviours at school: The behave application
2020
In the last years, an increasing awareness amongst educator and scholastic psychologists of the relevance to manage behavioural and emotional problems applying evidence-based approaches, and quasi-experimental designs is emerging. This request, however, must come to terms with certain barriers that persist in the school environment. The introduction of quantified methods to assess and monitor student's results, to evaluate the efficacy of the intervention, to understand the evolution of the single, is not part of the usual teacher's curriculum. The present paper describes the BEHAVE (Behavioral management model across Europe) application, a tool able to support the transition of all educato…
Multiverse Ethnography: A Qualitative Method for Gaming and Technology Use Research
2021
This article introduces multiverse ethnography as a systematic team-based qualitative method for studying the mechanical, structural and experiential properties of video games and other technological artefacts. Instead of applying the ethnographic method to produce a single in-depth account, multiverse ethnography includes multiple researchers carrying out coordinated synergetic ethnographic work on the same research object, thus producing a multiverse of interpretations and perspectives. To test the method, 41 scholars carried out a multiverse ethnography on two video games, Cyberpunk 2077 and Among Us. Explorative thematic findings regarding both titles are reported and methodological imp…
Changes in the Phytochemical Profile and Antioxidant Properties of Prunus persica Fruits after the Application of a Commercial Biostimulant Based on …
2022
Plant biostimulants are formulations that are experiencing great success from the perspective of sustainable agriculture. In this work, we evaluated the effect derived from the application of a biostimulant based on algae and yeast extracts (Expando®) on the agronomic yield and nutraceutical profile of two different cultivars (“Sugar Time” and “West Rose”) of Prunus persica (peach). Although, at the agronomic level, significant effects on production yields were not recorded, the biostimulant was able to reduce the ripening time, increase the fruit size, and make the number of harvestable fruits homogeneous. From a nutraceutical point of view, our determinations v…
Biomaterials for Biotechnological and Pharmaceutical application
2010
Simulation of granular organic fertilizer application by centrifugal spreader
2021
There is no specialized equipment designed to spread granular cylindrical organic fertilizer in the soil. There are also no rational recommendations available on how to spread this type of fertilizer. Mineral fertilizer spreaders are most often used for spreading granulated organic fertilizer. However, these fertilizers are significantly different from mineral fertilizers. Due to these differences, organic granular fertilizers often are spread unevenly, and the fertilizer does not reach the required working width. Furthermore, the rate of spreading is not accurate, and the fertilizer is often crushed too much. The objective of this research is to develop a simulation model for granular orga…
Local vs global motions in protein folding
2013
It is of interest to know whether local fluctuations in a polypeptide chain play any role in the mechanism by which the chain folds to the native structure of a protein. This question is addressed by analyzing folding and non-folding trajectories of a protein; as an example, the analysis is applied to the 37-residue triple β-strand WW domain from the Formin binding protein 28 (FBP28) (PDB ID: 1E0L). Molecular dynamics (MD) trajectories were generated with the coarse-grained united-residue force field, and one- and two-dimensional free-energy landscapes (FELs) along the backbone virtual-bond angle θ and backbone virtual-bond-dihedral angle γ of each residue, and principal components, respect…
Synthetic/ECM-inspired hybrid platform for hollow microcarriers with ROS-triggered nanoporation hallmarks
2017
Reactive oxygen species (ROS) are key pathological signals expressed in inflammatory diseases such as cancer, ischemic conditions and atherosclerosis. An ideal drug delivery system should not only be responsive to these signals but also should not elicit an unfavourable host response. This study presents an innovative platform for drug delivery where a natural/synthetic composite system composed of collagen type I and a synthesized polythioether, ensures a dual stimuli-responsive behaviour. Collagen type I is an extracellular matrix constituent protein, responsive to matrix metalloproteinases (MMP) cleavage per se. Polythioethers are stable synthetic polymers characterized by the presence o…
Design, Microfabrication and Characterization of a Power Delivery System for new Biomedical Applications
2017
This paper presents the design, microfabrication and characterization of a wireless power delivery system capable of driving a surface acoustic wave sensor (SAW) for biomedical applications. The system consists of two planar, spiral-square microcoils, which have been geometrically optimized in order to maximize the quality factor Q. The integration of the SAW - microcoil system into artificial implant sites will allow a real-time biofilm growth monitoring and treatment, providing countless advantages to the related medical applications.