Search results for "approach"
showing 10 items of 1654 documents
An overview of statin-induced myopathy and perspectives for the future
2020
Introduction: Statins remain the most commonly prescribed lipid-lowering drug class for the treatment of atherosclerotic cardiovascular disease. Their well-recognized side effects are known as statin-associated muscle symptom (SAMS). Some advances in this field have been made in recent years, but the understanding of the mechanisms has lagged. Investigating the specific role of the anti-HMGCR autoantibody, pharmacokinetic genetic variants, characterization of the known phenotypes of statin toxicity, in relation to clinical markers of disease, is of high importance. Areas covered: We summarized currently available findings (on PubMed) related to SAMS and discussed the therapeutic approaches,…
Pharmacogenetics and Forensic Toxicology: A New Step towards a Multidisciplinary Approach
2021
Pharmacogenetics analyzes the individual behavior of DNA genes after the administration of a drug. Pharmacogenetic research has been implemented in recent years thanks to the improvement in genome sequencing techniques and molecular genetics. In addition to medical purposes, pharmacogenetics can constitute an important tool for clarifying the interpretation of toxicological data in post-mortem examinations, sometimes crucial for determining the cause and modality of death. The purpose of this systematic literature review is not only to raise awareness among the forensic community concerning pharmacogenetics, but also to provide a workflow for forensic toxicologists to follow in cases of unk…
How to keep patient case sheet flows under control? A subset of ad hoc indicators and its statistical control in a healthcare organization.
2009
SCELTA E APPLICAZIONE DI NUOVI STANDARD DI MANOVRA NELLE FASI DI DECOLLO ED ATTERRAGGIO DELL’ELICOTTERO - MODELLO E SPERIMENTAZIONE -
Una zona o un ambiente ha tipicamente un livello sonoro che lo caratterizza e ci si aspetta che le variazioni di quell’ambiente in equilibrio dovute ad un evento acustico insolito alterino le sensazioni delle persone in quel contesto. Non ci si può riferire al buon senso per valutare se disturbiamo o danneggiamo il prossimo, è necessario individuare le fonti di rumore e valutare l’impatto ambientale tramite indagini di tipo qualitativo e fasi sperimentali di misura. Lo studio condotto ha correlato il dato qualitativo a quello quantitativo sia in ambito predittivo che tramite rilievi sul campo. Gli scopi e gli obiettivi sono incentrati a: ricercare una simulazione coerente di propagazione de…
EMISSION FACTORS, VEHICLE MODAL ACTIVITY AND ROAD OPERATIONS. A MESOSCOPIC APPROACH
2009
Current studies underline that vehicle emissions are highly linked to modal vehicle activity and a modal approach to traffic-related air quality modeling is suitable to estimate mobile source contribution to air quality. Pollutant emissions depend on characteristics of vehicles in traffic flow and on road operating conditions predictable after the implementation of the road project; then, the usual emission rate models do not predict properly the on-road vehicles emissions of modal traffic events, such as those ones occurring at intersections. Moreover modal activity analysis carried out at micro scale level, as required by modal emission models, will be still necessary to value reliable em…
Implementation of the Smart City Concept in Post-Socialist Cities : Rationales, Results, and Recommendations
2018
Unveiling the strong interaction among hadrons at the LHC
2020
One of the key challenges for nuclear physics today is to understand from first principles the effective interaction between hadrons with different quark content. First successes have been achieved using techniques that solve the dynamics of quarks and gluons on discrete space-time lattices1,2. Experimentally, the dynamics of the strong interaction have been studied by scattering hadrons off each other. Such scattering experiments are difficult or impossible for unstable hadrons3–6 and so high-quality measurements exist only for hadrons containing up and down quarks7. Here we demonstrate that measuring correlations in the momentum space between hadron pairs8–12 produced in ultrarelativistic…
The Early Bird gets the Word
2019
Success in an increasingly globalized world sets requirements for versatile communication skills and understanding about other cultures. One of the keys to success is versatile language skills, on which the European Commission spoke out as early as in 1995, recommending that every European citizen should learn two foreign languages in addition to their mother tongue. Now, more than twenty years later, the launch of early A1 language teaching that is to begin in the first grade in Finland, in January 2020, is a significant step towards this goal. Studies show that early foreign language learning needs to be carefully carried out in order to achieve positive effects and the effects that have …
Longitudinal evidence for an emotion-action lag on desire: The role of emotional understanding
2021
Abstract Many previous studies have found that children understand much earlier what a character who has a false belief will do than what a character will feel. This gap between the understanding of action and emotion is known as the belief-emotion lag and to this day there is no convincing explanation as to why it happens. There are also no studies that have explored whether this same gap occurs in the understanding of desire. This longitudinal study had a twofold objective: to explore the existence of a lag between the prediction of action and emotion based on desire, and to search for the role that specific emotions could have in children’s answers. To this end, we administered the Test …
Language Education Policies and Early Childhood Education
2020
This chapter discusses the importance of different types of early language education in the public system according to national policy in two geopolitical contexts: Continental Northern Europe and the UK. We define early language education policy as the language policies in early childhood education (ECE) including planning, practices, and ideologies related to the teaching and learning of languages. We present a variety of theoretical approaches and discuss their applicability to the field of early language education research. These approaches include traditional top-down policy implementation models as well as more dynamic and ecological theoretical approaches. Following that, we look at …