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Organotin(IV) derivatives with 5,7-disubstituted-1,2,4-triazolo[1,5-a]pyrimidine and their cytotoxic activities: The importance of being conformers

2014

Abstract The organotin(IV) compounds Me2SnCl2(dbtp)(1), Me2SnCl2(dbtp)2 (2), Et2SnCl2(dbtp) (3), Et2SnCl2(dbtp)2 (4), Et2SnCl2(dptp) (5), nBu2SnCl2(dbtp)2 (6), nBu2SnCl2(dptp) (7), Ph2SnCl2(dbtp) (8), Ph2SnCl2(EtOH)2(dptp)2 (9), where dbtp = 5,7-di-tert-butyl-1,2,4-triazolo[1,5-a]pyrimidine and dptp = 5,7-diphenyl-1,2,4-triazolo [1,5-a]pyrimidine, have been tested by MTT for their cytotoxic activity on three tumor cell lines, HepG2 (human hepatocellular carcinoma), HeLa (human cervix adenocarcinoma) and MCF-7 (human breast cancer). Except for 1 and 2, which were ineffective, all compounds significantly showed a dose-dependent anti-proliferative effect against the three cell lines. By calcul…

DenticityPyrimidinebiologyStereochemistryAcridine orangeCrystal structureorganotin(iv)biology.organism_classificationInorganic ChemistryHeLachemistry.chemical_compoundTrigonal bipyramidal molecular geometrycrustalli structurechemistrySettore CHIM/03 - Chimica Generale E InorganicaSettore BIO/10 - Biochimicain vitro anticancer acetivi tuMaterials ChemistryPhysical and Theoretical ChemistryEthidium bromideConformational isomerismtriazolipyrimidineTriazolopyrimidine Organotin(IV) Apoptosis In vitro anticancer activity Crystal structureapprossimativaInorganica Chimica Acta
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