Search results for "arch"

showing 10 items of 44654 documents

Activation of α-secretase as an approach for treatment of Alzheimer’s disease

2006

α secretasebiologyChemistryAmyloid precursor proteinbiology.proteinCancer researchDisease

Desymmetrization of Prochiral Cyclobutanones via Nitrogen Insertion: A Concise Route to Chiral γ‐Lactams

2021

Abstract Asymmetric access to γ‐lactams is achieved via a cyclobutanone ring expansion using widely available (1S,2R)‐1‐amino‐2‐indanol for chiral induction. Mechanistic analysis of the key N,O‐ketal rearrangement reveals a Curtin–Hammett scenario, which enables a downstream stereoinduction (up to 88:12 dr) and is corroborated by spectroscopic, crystallographic, and computational studies. In combination with an easy deprotection protocol, this operationally simple sequence allows the synthesis of a range of optically pure γ‐lactams, including those bearing all‐carbon quaternary stereocenters. In addition, the formal synthesis of drug molecules baclofen, brivaracetam, and pregabalin further …

γ-lactamsChiral auxiliary010405 organic chemistryChemistryasymmetric synthesisEnantioselective synthesisCyclobutanoneGeneral Chemistry010402 general chemistryRing (chemistry)01 natural sciencesCombinatorial chemistryDesymmetrizationCatalysis0104 chemical sciencesStereocenterdesymmetrizationFormal synthesischemistry.chemical_compoundMoleculecyclobutanoneResearch ArticlesResearch ArticleAsymmetric Synthesis | Hot PaperAngewandte Chemie International Edition

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The Use of Stable Isotope Ratio Analysis to Trace European Sea Bass (D. labrax) Originating from Different Farming Systems

2020

This study aimed to determine whether isotopic ratio mass spectrometry (IRMS) can discriminate farmed European sea bass according to different farming systems and geographic origins. Dicentrarchus labrax of commercial size from three different rearing systems (concrete tank inland, sea cages, and extensive methods in valleys or salt works) were collected at the trading period (autumn&ndash

δ18Ostable isotopesgeographic origin01 natural sciencesArticle0404 agricultural biotechnologyAquacultureSettore AGR/20 - Zoocolturelcsh:ZoologyDicentrarchus labrax<i>Dicentrarchus labrax</i>lcsh:QL1-991Settore BIO/06 - Anatomia Comparata E CitologiaSea bassIsotope-ratio mass spectrometryaquaculture; Dicentrarchus labrax; stable isotopes; traceability; farming system; geographic origin; IRMS; sea bass; fish; authenticationfishaquaculture Dicentrarchus labrax stable isotopes traceability farming system geographic origin IRMS sea bass fish authenticationlcsh:Veterinary medicineGeneral Veterinaryδ13CbiologyStable isotope ratiobusiness.industry010401 analytical chemistry04 agricultural and veterinary sciencesδ15NIRMSbiology.organism_classification040401 food science0104 chemical sciencesFisherytraceabilityaquaculturelcsh:SF600-1100authenticationEnvironmental sciencefarming systemAnimal Science and ZoologyDicentrarchusbusinesssea bassAnimals

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Crystal structures of 4-chloro-pyridine-2-carbo-nitrile and 6-chloro-pyridine-2-carbo-nitrile exhibit different inter-molecular π-stacking, C-H⋯Nnitr…

2015

The crystal structures of two chlorocyanopyridines, namely 4-chloropyridine-2-carbonitrile and 6-chloropyridine-2-carbonitrile, exhibit unique intermolecular C—H⋯Nnitrile, C—H⋯Npyridine and offset face-to-face π-stacking interactions.

π-stackingC—H...N interactionscrystal structureNitrileStereochemistrySubstituentStackingSolid-stateCrystal structureC—H⋯N interactions010402 general chemistryRing (chemistry)01 natural sciencesResearch Communicationschlorocyanopyridinechemistry.chemical_compoundPyridineGeneral Materials ScienceCrystallography010405 organic chemistryGeneral ChemistryCondensed Matter Physics0104 chemical sciences3. Good healthchlorocyanopyridineCrystallographychemistryQD901-999Acta crystallographica. Section E, Crystallographic communications

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Вклад Мирдзы Аболы (1923-2007) в расширение латышско-белорусских литературных связей

2018

Абола Мирдзаархивное наследиеarchival heritageBelarusian-Latvian-Belarusian dictionary:HUMANITIES and RELIGION [Research Subject Categories]Abola Myrdzaлатвийские-белорусские литературные связилатвiйска-беларускiя лiтаратурныя сувязiархiуная спадчынаАбала Мiрдзабеларуска-латышска-беларускi слоунiкLatvian-Belarusian literary relationsбелорусско-латышско-белорусский словарь

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Теория алгоритмов и программ

1986

Сборник посвящен исследованию различных типов вычислительных устройств, таких как альтернирующие вероятностные машины, а также проблемам индуктивного синтеза программ.

АвтоматыПрограммированиеТеория алгоритмовAlgoritmi:MATHEMATICS::Applied mathematics::Theoretical computer science [Research Subject Categories]Matemātiskā programmēšanaПрограммное обеспечение ЭВМ

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