Search results for "arki"

Amorphous Ropinirole-Loaded Mucoadhesive Buccal Film: A Potential Patient-Friendly Tool to Improve Drug Pharmacokinetic Profile and Effectiveness

2020

Nowadays the therapeutic strategies to manage Parkinson&rsquo

Park Parking

2019

The book containing this project, presents the outcomes of the 1st International Workshop “Dubai Pop-Up: Architecture in a Transient City” organized in March 2017 at d3-Dubai Design District by Al Ghurair University in collaboration with other international academic partners. Local students of architecture worked together with students coming from an international background, in order to foster a shared design vision through a collective cultural growth and reciprocal awareness. The participants had the opportunity to visit both recent accomplished buildings and projects under construction, confronting themselves with the local context in a dynamic and stimulating environment. The workshop …

Cerebellar magnetic stimulation decreases levodopa-induced dyskinesias in Parkinson disease

2009

BACKGROUND: The neural mechanisms and the circuitry involved in levodopa-induced dyskinesia (LID) are still partially obscure. LID can be considered the consequence of an abnormal pattern or code of activity that originates and is conveyed from the basal ganglia to the thalamus and the cortical motor areas. However, not only striatothalamocortical motor circuits but also other interconnected pathways could be implicated in its pathogenesis. METHODS: In a series of experiments, we applied repetitive transcranial magnetic stimulation (rTMS) over the lateral cerebellum in a group of patients with advanced Parkinson disease, to investigate whether modulation of cerebellothalamocortical circuits…

Both Short- and Long-Acting D-1/D-2 Dopamine Agonists Induce Less Dyskinesia than l-DOPA in the MPTP-Lesioned Common Marmoset (Callithrix jacchus)

2002

Abstract The current concept of dyskinesia is that pulsatile stimulation of D-1 or D-2 receptors by l -DOPA or short-acting dopamine agonists is more likely to induce dyskinesia compared to long-acting drugs producing more continuous receptor stimulation. We now investigate the ability of two mixed D-1/D-2 agonists, namely pergolide (long-acting) and apomorphine (short-acting), to induce dyskinesia in drug-naive MPTP-lesioned primates, compared to l -DOPA. Adult common marmosets ( Callithrix jacchus ) were lesioned with MPTP (2 mg/kg/day sc for 5 days) and subsequently treated with equieffective antiparkinsonian doses of l -DOPA, apomorphine, or pergolide for 28 days. l -DOPA, apomorphine, …

GDNF reverses priming for dyskinesia in MPTP-treated, L-DOPA-primed common marmosets

2001

Parkinson's disease (PD) is associated with a progressive loss of dopamine neurons in the substantia nigra and degeneration of dopaminergic terminals in the striatum. Although L-DOPA treatment provides the most effective symptomatic relief for PD it does not prevent the progression of the disease, and its long-term use is associated with the onset of dyskinesia. In rodent and primate studies, glial cell line-derived neurotrophic factor (GDNF) may prevent 6-OHDA- or MPTP-induced nigral degeneration and so may be beneficial in the treatment of PD. In this study, we investigate the effects of GDNF on the expression of dyskinesia in L-DOPA-primed MPTP-treated common marmosets, exhibiting dyskin…

Lenalidomide induced reversible parkinsonism, dystonia, and dementia in subclinical Creutzfeldt-Jakob disease

2018

Zur Geschichte der öffentlichen Anlagen und Gärten der Stadt Riga

1913

MS-tautia sairastavien selviytyminen ADL-toiminnoista kahden vuoden seurannan aikana ICF-luokituksen itsestä huolehtimisen ja liikkumisen osa-alueill…

2006

Assessing the sustainability of water companies: A synthetic indicator approach

2016

Performance indicators (PIs) are essential in the benchmarking process used to rate and rank water companies. However, a set of individual PIs does not provide a holistic assessment of company performance from multiple perspectives. A multidimensional evaluation of the performance of water companies can be achieved by aggregating the PIs into a synthetic indicator. Although the concept of sustainability involves economic, environmental and social criteria, most of the previous studies have not considered these three dimensions simultaneously. This paper discusses a process of indicator aggregation using two approaches based on multi-criteria decision analysis to evaluate and compare the sus…

How does seasonality affect water reuse possibilities? An efficiency and cost analysis

2012

Abstract Because of the harsh conditions of water stress and seasonal water demand in many zones, water reuse has emerged as a key alternative for achieving sustainable water management. An efficient performance by wastewater treatment plants (WWTPs) in technical and economic terms favors water reuse. However, seasonality in the flow of wastewater and in the pollutant load may be a determining factor in the efficiency of WWTPs. To evaluate if seasonality affects WWTP efficiency, analytical benchmarking methodology Data Envelopment Analysis (DEA) is used to obtain an average efficiency score for seasonal and non-seasonal plants. Given the importance of extended aeration (EA) and activated sl…