Search results for "arki"

A Visualizable Test Problem Generator for Many-Objective Optimization

2022

Visualizing the search behavior of a series of points or populations in their native domain is critical in understanding biases and attractors in an optimization process. Distancebased many-objective optimization test problems have been developed to facilitate visualization of search behavior in a two-dimensional design space with arbitrarily many objective functions. Previous works have proposed a few commonly seen problem characteristics into this problem framework, such as the definition of disconnected Pareto sets and dominance resistant regions of the design space. The authors’ previous work has advanced this research further by providing a problem generator to automatically create use…

Lasten media-arjen valot ja varjot : Mediamuffinssi lasten mediasuhteen kuvastajana

2008

A Watermarking of Medical Image : New Approach Based On "Multi-Layer" Method

2011

In order to contribute to security sharing and transmission of medical images, this paper propose a new approach for Watermarking image based on the techniques of Code Division Multiple Access (CDMA), Discrete Wavelet transform (DWT) and Error Correcting Code (ECC). The motivation of this approach is to improve the quantity of data integration with the conservation of the image visual quality. Therefore, this work permits to the user the capacity to correct the possible alterations if it exists. IRM and Echographic medical image are used to experiment this approach.

Non-Skeletal Activities of Vitamin D: From Physiology to Brain Pathology.

2019

Vitamin D is a secosteroid hormone regulating the expression of almost 900 genes, and it is involved in the regulation of calcium and phosphate metabolism, immune response, and brain development. Low blood vitamin D levels have been reported in patients affected by various diseases. Despite a large amount of literature data, there is uncertainty surrounding the role of vitamin D as a serum biomarker in Alzheimer’s disease (AD) and Parkinson’s disease (PD). Indeed, the lack of internationally recognized 25(OH)D3 reference measurement procedures and standard materials in the past led to unstandardized serum total 25(OH)D3 results among research and clinical care laboratories. Thus…

Role of serotonin in central dopamine dysfunction

2010

The interaction between serotonin (5-HT) and dopamine (DA)-containing neurons in the brain is a research topic that has raised the interest of many scientists working in the field of neuroscience since the first demonstration of the presence of monoamine-containing neurons in the mid 1960. The bulk of neuroanatomical data available clearly indicate that DA-containing neurons in the brain receive a prominent innervation from serotonin (5-hydroxytryptamine, 5-HT) originating in the raphe nuclei of the brainstem. Compelling electrophysiological and neurochemical data show that 5-HT can exert complex effects on the activity of midbrain DA neurons mediated by its various receptor subtypes. The m…

In Vivo Microdialysis in Parkinson’s Research

2009

Parkinson’s disease (PD) is a progressive neurodegenerative disorder that is primarily characterized by the degeneration of dopamine (DA) neurons in the nigrostriatal system, which in turn produces profound neurochemical changes within the basal ganglia, representing the neural substrate for parkinsonian motor symptoms. The pathogenesis of the disease is still not completely understood, but environmental and genetic factors are thought to play important roles. Research into the pathogenesis and the development of new therapeutic intervention strategies that will slow or stop the progression of the disease in human has rapidly advanced by the use of neurotoxins that specifically target DA ne…

Ketogenic diet in neuromuscular and neurodegenerative diseases.

2014

An increasing number of data demonstrate the utility of ketogenic diets in a variety of metabolic diseases as obesity, metabolic syndrome, and diabetes. In regard to neurological disorders, ketogenic diet is recognized as an effective treatment for pharmacoresistant epilepsy but emerging data suggests that ketogenic diet could be also useful in amyotrophic lateral sclerosis, Alzheimer, Parkinson’s disease, and some mitochondriopathies. Although these diseases have different pathogenesis and features, there are some common mechanisms that could explain the effects of ketogenic diets. These mechanisms are to provide an efficient source of energy for the treatment of certain types of neurodege…

Benchmarking Saliency Detection Methods on Multimodal Image Data

2018

Saliency detecmage processing. Most of the work is adapted to the specific application and available dataset. The present work is about a comparative analysis of saliency detection for multimodal images dataset. There were many researches on the detection of saliency on several types of images, such as multispectral, natural, 3D and so on. This work presents a first focused study on saliency detection on multimodal images. Our database was extracted from acquisitions on cultural heritage wall paintings that contain four modalities UV, IR, Visible and fluorescence. In this paper, the analysis has been performed for many methods on saliency detection. We evaluate the performance of each metho…

A novel bio-orthogonal cross-linker for improved protein/protein interaction analysis

2015

International audience; The variety of protein cross-linkers developed in recent years illustrates the current requirement for efficient reagents optimized for mass spectrometry (MS) analysis. To date, the most widely used strategy relies on commercial cross-linkers that bear an isotopically labeled tag and N-hydroxysuccinimid-ester (NHS-ester) moieties. Moreover, an enrichment step using liquid chromatography is usually performed after enzymatic digestion of the cross-linked proteins. Unfortunately, this approach suffers from several limitations. First, it requires large amounts of proteins. Second, NHS-ester cross-linkers are poorly efficient because of their fast hydrolysis in water. Fin…

A new evolutionary paradigm for the Parkinson disease gene DJ-1.

2006

The DJ-1 gene is extensively studied because of its involvement in familial Parkinson disease. DJ-1 belongs to a complex superfamily of genes that includes both prokaryotic and eukaryotic representatives. We determine that many prokaryotic groups, such as proteobacteria, cyanobacteria, spirochaetes, firmicutes, or fusobacteria, have genes, often incorrectly called "Thij," that are very close relatives of DJ-1, to the point that they cannot be clearly separated from the eukaryotic DJ-1 genes by phylogenetic analyses of their sequences. In addition, and contrary to a previous study that suggested that DJ-1 genes were animal specific, we show that DJ-1 genes are found in at least 5 of the 6 ma…